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3.1.4.3: phospholipase C

This is an abbreviated version!
For detailed information about phospholipase C, go to the full flat file.

Word Map on EC 3.1.4.3

Reaction

a phosphatidylcholine
+
H2O
=
1,2-diacyl-sn-glycerol
 +
phosphocholine

Synonyms

alpha-toxin, Beta toxin, Beta-hemolysin, Beta-toxin, broad-range phospholipase C, Cbp, CegC1, cholinespecific glycerophosphodiester phosphodiesterase, Clostridium oedematiens beta- and gamma-toxins, Clostridium welchii alpha-toxin, cPC-PLC, CpPLC, Dot/Icm-injected effector, Gamma-toxin, haemolytic phospholipase C, Heat labile-hemolysin, heat-labile hemolysin, Hemolysin, hemolytic PLC, hNPP6, Lecithinase, lecithinase C, lipophosphodiesterase C, lipophosphodiesterase I, Lpg0012, mNPP6, More, mPC-PLC, MTP40 antigen, non-specific phospholipase C, nonhemolytic PLC, nonspecific phospholipase C, NPC, NPC1, NPC1a, NPC1b, NPC2, NPC2a, NPC2b, NPC3, NPC3a, NPC3b, NPC4, NPC5, NPC6, NPC6a, NPC6b, NPC6c, NPC6d, NPP6, nucleotide pyrophosphatase/phosphodiesterase, PC-PLC, phosphatidase C, Phosphatidylcholine cholinephosphohydrolase, phosphatidylcholine phospholipase C, phosphatidylcholine specific phospholipase C, phosphatidylcholine-hydrolysing phospholipase C, phosphatidylcholine-hydrolyzing phospholipase C, phosphatidylcholine-preferring PLC, phosphatidylcholine-specific phospholipase C, phospholipase C, phospholipase C beta 1, phospholipase C gamma 1, phospholipase C gamma 2, phospholipase C/sphingomyelinase, phospholipase C/sphingomyelinase HR2, PLC, PLC-Bt, PLC-H, PLC-N, PLC1, PLC2, PlcB, PLCBC, PLCbeta, plcC, PlcC protein, PlcC/CegC1, PLCG1, PLCG2, PLCgamma, PlcHR2, PlcHR2 toxin, PLCLM, protein kinase C, PtdCho-PLC, Rv3487c, SMase, SMc00171, sphingomyelinase, type C phospholipase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.3 phospholipase C

Specific Activity

Specific Activity on EC 3.1.4.3 - phospholipase C

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.002
-
microsomal fraction
0.00245
-
substrate: membrane form variant surface glycoproteins
0.029
-
substrate: p-nitrophenylphosphorylcholine
0.56
-
substrate: p-nitrophenylphosphorylcholine
0.78
-
PLC-beta 1b, substrate: phosphatidylinositol
1.34
-
PLC-beta 1a, substrate: phosphatidylinositol
1010
-
substrate: lecithin
1050000
-
substrate: phosphatidylinositol-4,5-bisphosphate
1268
-
substrate: phosphatidylinositol-4,5-bisphosphate, PLC d1 with poly-His-tail, no significant change of activity after cleavage of poly-His-tail, expression at 16°C for 72 h
13190
-
37°C
1575
-
substrate: phosphatidylcholine
1620
-
substrate: lecithin
17.5
-
substrate: phosphatidylcholine
1940
-
pH 7.3, 37°C
2.083
-
substrate: dipalmitoylphosphatidylcholine
2100
-
substrate: phosphatidylcholine
3 - 5
-
substrate: phosphatidylinositol-4,5-bisphosphate
404
-
substrate: phosphatidylinositol-4,5-bisphosphate, PLC d3 with poly-His-tail, no significant change of activity after cleavage of poly-His-tail, expression at 16°C for 72 h
53.13
-
substrate: phosphatidylinositol-4,5-bisphosphate
74.3
-
C-2, substrate: lecithin
84.6
-
C-1, substrate: lecithin
additional information