Any feedback?
Literature summary for 3.1.4.3 extracted from
- Phosphatidylcholine-specific phospholipase C activation in epithelial ovarian cancer cells (2008), Cancer Res., 68, 6541-6549.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | elucidation of the mechanisms responsible for aberrant phosphatidylcholine metabolism in cancer cells may allow identification of novel biomarkers of tumor progression and design of new targeted anticancer therapies | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| tricyclodecan-9-yl-potassium xanthate | The recovery of both variables to their original levels in serum-restimulated (or lysophosphatidic acid-restimulated) EOC cells is strongly delayed, for at least 24 h, in the presence of the PC-PLC inhibitor tricyclodecan-9-yl-potassium xanthate (D609). The S-phase of serum-restimulated EONT cells is not sensitive to D609 | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
| plasma membrane | of cancer cells | Homo sapiens | 5886 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 66000 | - |
Western blot analysis | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| EONT cell | nontumoral (normal or immortalized) counterparts (EONT) | Homo sapiens | - |
| epithelial ovarian cancer cell | different cell lines of epithelial ovarian cancer cells (EOC) compared with nontumoral (normal or immortalized) counterparts (EONT) | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + H2O | - |
Homo sapiens | 1,2-diacylglycerol + phosphorylcholine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PC-PLC | - |
Homo sapiens |
| phosphatidylcholine-specific phospholipase C | - |
Homo sapiens |
| phospholipase C | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
