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Literature summary for 3.1.4.3 extracted from
- Methylmercury-induced IL-6 release requires phospholipase C activities (2011), Neurosci. Lett., 496, 152-156.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| methylmercury | MeHg, activation of PLC | Mus musculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D609 | - |
Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Mus musculus C57BL/6 | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| glia | primary | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PC-PLC | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | PLC activation initiates the calcium signaling system. Phospholipase C activity is necessary for methylmercury-induced interleukin-6 release. Sustained interleukin-6 exposure can be detrimental to cerebellar granule neurons, one of the major cellular targets of methylmercury cytotoxicity | Mus musculus |
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