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Information on EC 5.3.99.3 - prostaglandin-E synthase

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EC Tree
     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.99 Other intramolecular oxidoreductases
                5.3.99.3 prostaglandin-E synthase
IUBMB Comments
Brings about the opening of the epidioxy bridge. Requires glutathione.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
CPGES, cPGES/p23, cytosolic prostaglandin E synthase, cytosolic prostaglandin E(2) synthase, cytosolic prostaglandin E(2) synthase-2, endoperoxide isomerase, Isomerase, prostaglandin R2 E-, membrane-associated PGE2 synthase, membrane-associated prostaglandin E synthase-2, membrane-associated prostaglandin E(2) synthase-1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate = (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate
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(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
show the reaction diagram