Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glutathione | - |
Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | enzyme inhibition can be useful for treating pain, fever, and anorexia | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in A-549 cells, HeLa cells, HEK-293 cells, RAW 264.7 cells, Pichia pastoris strain KM71H, and Sf9 insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(4-dodecanoyl-1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)propanoic acid | - |
Homo sapiens | |
4-(3-chlorobenzyl)-2,6-bis[4-(trifluoromethoxy)phenyl]-4H-thieno[3,2-b]pyrrole-5-carboxylic acid | - |
Homo sapiens | |
AF3442 | - |
Homo sapiens | |
licofelone | - |
Homo sapiens | |
Oxacillin | - |
Homo sapiens | |
YS121 | reversible and noncompetitive inhibition | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | Homo sapiens | - |
Prostaglandin E2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epididymis | - |
Homo sapiens | - |
epithelial cell | - |
Homo sapiens | - |
seminal vesicle | - |
Homo sapiens | - |
Sertoli cell | - |
Homo sapiens | - |
spermatocyte | - |
Homo sapiens | - |
spermatogonium | - |
Homo sapiens | - |
vas deferens | ampulla | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin E2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotrimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
microsomal prostaglandin E2 synthase-1 | - |
Homo sapiens |
mPGES-1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0034 | - |
pH and temperature not specified in the publication | Homo sapiens | YS121 | |
0.006 | - |
pH and temperature not specified in the publication | Homo sapiens | licofelone |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme shows elevated levels in the cartilages and chondrocytes of patients suffering from osteoarthritis. The enzyme is overexpressed in 80% of several cancer cells | up |