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Literature summary for 5.3.99.3 extracted from

  • Hamza, A.; Abdulhameed, M.D.; Zhan, C.G.
    Understanding microscopic binding of human microsomal prostaglandin E synthase-1 with substrates and inhibitors by molecular modeling and dynamics simulation (2008), J. Phys. Chem. B, 112, 7320-7329.
    View publication on PubMed
Search for more literature for 5.3.99.3

Application

Application Comment Organism
medicine mPGES-1 is a promising target for the development of anti-inflammatory drugs Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
leukotriene C4
-
 Homo sapiens
MK-886
-
 Homo sapiens
NS-398
-
 Homo sapiens
sulindac
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Homo sapiens
-
 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14684
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Homo sapiens (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Subunits

Subunits Comment Organism
trimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
microsomal prostaglandin E synthase-1
-
 Homo sapiens
mPGES-1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
glutathione
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0016
-
-
 Homo sapiens MK-886
0.02
-
-
 Homo sapiens NS-398
0.08
-
-
 Homo sapiens sulindac