Inhibitors | Comment | Organism | Structure |
---|---|---|---|
11-oxo-beta-boswellic acid | - |
Homo sapiens | |
3-O-acetyl-28-hydroxylupeolic acid | 31.1% residual activity at 0.01 mM | Homo sapiens | |
3-O-acetyllupeolic acid | 51.4% residual activity at 0.01 mM | Homo sapiens | |
3-O-acteyl-11-oxo-beta-boswellic acid | - |
Homo sapiens | |
3-O-acteyl-beta-boswellic acid | - |
Homo sapiens | |
3-oxo-8,24-dienetirucallic acid | 16.7% residual activity at 0.01 mM | Homo sapiens | |
3alpha-acetoxy-7,24-dienetirucallic acid | 20.6% residual activity at 0.01 mM | Homo sapiens | |
3alpha-acetoxy-8,24-dienetirucallic acid | 36.8% residual activity at 0.01 mM | Homo sapiens | |
3alpha-hydroxy-7,24-dienetirucallic acid | 29.6% residual activity at 0.01 mM | Homo sapiens | |
3alpha-hydroxy-8,24-dienetirucallic acid | 3.5% residual activity at 0.01 mM | Homo sapiens | |
3beta-hydroxy-8,24-dienetirucallic acid | 29.2% residual activity at 0.01 mM | Homo sapiens | |
4,(23)-dihydro-11-oxo-roburic acid | 21.6% residual activity at 0.01 mM | Homo sapiens | |
4,(23)-dihydronyctanthic acid | 74.1% residual activity at 0.01 mM | Homo sapiens | |
4,(23)-dihydroroburic acid | 92.4% residual activity at 0.01 mM | Homo sapiens | |
beta-boswellic acid | - |
Homo sapiens | |
lupeolic acid | 43.1% residual activity at 0.01 mM | Homo sapiens | |
roburic acid | 83.9% residual activity at 0.01 mM | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | Homo sapiens | - |
Prostaglandin E2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin E2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
microsomal prostaglandin E2 synthase-1 | - |
Homo sapiens |
mPGES-1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0004 | - |
at pH 7.4 and 4°C | Homo sapiens | 3alpha-acetoxy-8,24-dienetirucallic acid | |
0.0004 | - |
at pH 7.4 and 4°C | Homo sapiens | 3alpha-acetoxy-7,24-dienetirucallic acid | |
0.0009 | - |
at pH 7.4 and 4°C | Homo sapiens | 3-oxo-8,24-dienetirucallic acid | |
0.0009 | - |
at pH 7.4 and 4°C | Homo sapiens | 3-O-acetyl-28-hydroxylupeolic acid | |
0.001 | - |
at pH 7.4 and 4°C | Homo sapiens | 4,(23)-dihydro-11-oxo-roburic acid | |
0.0011 | - |
at pH 7.4 and 4°C | Homo sapiens | 3alpha-hydroxy-8,24-dienetirucallic acid | |
0.0012 | - |
at pH 7.4 and 4°C | Homo sapiens | 3beta-hydroxy-8,24-dienetirucallic acid | |
0.003 | - |
at pH 7.4 and 4°C | Homo sapiens | 3alpha-hydroxy-7,24-dienetirucallic acid | |
0.0085 | - |
at pH 7.4 and 4°C | Homo sapiens | lupeolic acid | |
0.01 | - |
at pH 7.4 and 4°C | Homo sapiens | 3-O-acetyllupeolic acid | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4 and 4°C | Homo sapiens | roburic acid | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4 and 4°C | Homo sapiens | 4,(23)-dihydroroburic acid | |
0.01 | - |
IC50 above 0.01 mM, at pH 7.4 and 4°C | Homo sapiens | 4,(23)-dihydronyctanthic acid |