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Literature summary for 5.3.99.3 extracted from

  • Li, Y.; Angelastro, M.; Shimshock, S.; Reiling, S.; Vaz, R.J.
    On the mechanism of microsomal prostaglandin E synthase type-2--a theoretical study of endoperoxide reaction with MeS- (2010), Bioorg. Med. Chem. Lett., 20, 338-340.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
R126A the mutation of the enzyme abolishes its PGES activity to exhibit a novel glutathione-dependent reductase activity Homo sapiens
R126Q the mutation of the enzyme abolishes its PGES activity to exhibit a novel glutathione-dependent reductase activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Homo sapiens
-
Prostaglandin E2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
Homo sapiens Prostaglandin E2
-
?

Synonyms

Synonyms Comment Organism
microsomal prostaglandin E synthase type-2
-
Homo sapiens
mPGES-2
-
Homo sapiens