Literature summary for 5.3.99.3 extracted from

Camacho, M.; Gerboles, E.; Escudero, J.R.; Anton, R.; Garcia-Moll, X.; Vila, L.
Microsomal prostaglandin E synthase-1, which is not coupled to a particular cyclooxygenase isoenzyme, is essential for prostaglandin E(2) biosynthesis in vascular smooth muscle cells (2007), J. Thromb. Haemost., 5, 1411-1419.

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Activating Compound

Activating Compound	Comment	Organism	Structure
interleukin 1beta	induces isoform mPGES-1 and subsequent production of prostaglandin E2, while production of prostaglandin I2 is reduced by increased expression of mPGES-1	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform mPGES-1	-
Homo sapiens	Q9H7Z7	isoform mPGES-2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
vascular smooth muscle cell	cells express both microsomal isoforms mPGES-1 and mPGES-2 and cytosolic isoform cPGES	Homo sapiens	-
vascular smooth muscle cell	cells express both microsomal isoforms mPGES-1 and mPGES-2 and cytosolic isoform cPGES. Isoform mPGES-1 contributes most to total activity and is induced by interleukin IL-1beta, which in turn reduces the ability of cells to produce prostaglandin I2	Homo sapiens	-

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Release 2023.1 (January 2023)