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Literature summary for 5.3.99.3 extracted from

  • Hetu, P.O.; Ouellet, M.; Falgueyret, J.P.; Ramachandran, C.; Robichaud, J.; Zamboni, R.; Riendeau, D.
    Photo-crosslinking of proteins in intact cells reveals a dimeric structure of cyclooxygenase-2 and an inhibitor-sensitive oligomeric structure of microsomal prostaglandin E2 synthase-1 (2008), Arch. Biochem. Biophys., 477, 155-162.
    View publication on PubMed
Search for more literature for 5.3.99.3

Inhibitors

Inhibitors Comment Organism Structure
MF63
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
17000
-
 monomer, determined by SDS-PAGE and Western blot analysis Homo sapiens
33000
-
 dimer, determined by SDS-PAGE and Western blot analysis, crosslinked subunits Homo sapiens
45000
-
 trimer, determined by SDS-PAGE and Western blot analysis, crosslinked subunits Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Homo sapiens
-
 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Homo sapiens (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Subunits

Subunits Comment Organism
oligomer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
microsomal prostaglandin E2 synthase-1
-
 Homo sapiens
mPGES-1
-
 Homo sapiens