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Literature summary for 5.3.99.3 extracted from

  • Lu, D.; Han, C.; Wu, T.
    Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression (2011), Gastroenterology, 140, 2084-2094.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cholangiocarcinoma cell
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Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
Homo sapiens Prostaglandin E2
-
?

Synonyms

Synonyms Comment Organism
microsomal prostaglandin E synthase-1
-
Homo sapiens
mPGES
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Homo sapiens

General Information

General Information Comment Organism
malfunction mPGES-1 knockdown delays tumor formation and reduced tumor weight in human cholangiocarcinoma tissue Homo sapiens
metabolism mPGES-1 is a rate-limiting enzyme that is coupled with cyclooxygenase-2 in the synthesis of prostaglandin E2 Homo sapiens
physiological function overexpression of mPGES-1 in human cholangiocarcinoma cells increases tumor cell proliferation, migration, invasion, and colony formation. mPGES-1 inhibits the expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), leading to activation of the epidermal growth factor/phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathways in cholangiocarcinoma cells Homo sapiens