Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cholangiocarcinoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin E2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
microsomal prostaglandin E synthase-1 | - |
Homo sapiens |
mPGES | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | mPGES-1 knockdown delays tumor formation and reduced tumor weight in human cholangiocarcinoma tissue | Homo sapiens |
metabolism | mPGES-1 is a rate-limiting enzyme that is coupled with cyclooxygenase-2 in the synthesis of prostaglandin E2 | Homo sapiens |
physiological function | overexpression of mPGES-1 in human cholangiocarcinoma cells increases tumor cell proliferation, migration, invasion, and colony formation. mPGES-1 inhibits the expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), leading to activation of the epidermal growth factor/phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathways in cholangiocarcinoma cells | Homo sapiens |