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Literature summary for 5.3.99.3 extracted from

  • Isono, M.; Suzuki, T.; Hosono, K.; Hayashi, I.; Sakagami, H.; Uematsu, S.; Akira, S.; DeClerck, Y.A.; Okamoto, H.; Majima, M.
    Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice (2011), Life Sci., 88, 693-700.
    View publication on PubMed
Search for more literature for 5.3.99.3

Application

Application Comment Organism
medicine inhibition of mPGES-1 may have clinical utility in the management of bone cancer pain Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Lewis lung carcinoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Mus musculus Prostaglandin E2
-
 ?

Synonyms

Synonyms Comment Organism
microsomal prostaglandin E synthase-1
-
 Mus musculus
mPGES-1
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
glutathione
-
 Mus musculus

General Information

General Information Comment Organism
malfunction PGES-1-deficient mice exhibit reduced tumor growth in bone marrow and significantly fewer spontaneous flinches and their onset is several days later compared to wild type mice Mus musculus
physiological function microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice Mus musculus