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Disease on EC 5.3.99.3 - prostaglandin-E synthase

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DISEASE
TITLE OF PUBLICATION
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Aberrant Crypt Foci
Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.
Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1.
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Acute Kidney Injury
Aggravation of acute kidney injury by mPGES-2 down regulation is associated with autophagy inhibition and enhanced apoptosis.
Amelioration of cisplatin nephrotoxicity by genetic or pharmacologic blockade of prostaglandin synthesis.
Author Correction: Aggravation of acute kidney injury by mPGES-2 down regulation is associated with autophagy inhibition and enhanced apoptosis.
Acute Lung Injury
Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice.
Adenocarcinoma
15-Hydroxyprostaglandin dehydrogenase as a marker in colon carcinogenesis: analysis of the prostaglandin pathway in human colonic tissue.
Clinical significance of prostaglandin E synthase expression in gastric cancer tissue.
Expression of COX-2 and PGE synthase and synthesis of PGE(2)in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors.
Expression of cyclo-oxygenase 1 and 2, prostaglandin E synthase and transforming growth factor beta1, and their relationship with vascular endothelial growth factors A and C, in primary adenocarcinoma of the small intestine.
Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines.
Expression of prostaglandin E synthase in Barrett's cancer.
Hypoxia and prostaglandin E receptor 4 signalling pathways synergise to promote endometrial adenocarcinoma cell proliferation and tumour growth.
Inhibition of GSH-dependent PGH2 isomerase in mammary adenocarcinoma cells by allicin.
Microsomal prostaglandin E synthase-1 inhibition blocks proliferation and enhances apoptosis in oesophageal adenocarcinoma cells without affecting endothelial prostacyclin production.
NADPH Oxidase NOX5-S and NF-?B1 Mediate Acid-Induced Microsomal Prostaglandin Synthase-1 (Mpges1) Expression in Barrett's Esophageal Adenocarcinoma (EA) Cells.
Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis.
Adenoma
15-Hydroxyprostaglandin dehydrogenase as a marker in colon carcinogenesis: analysis of the prostaglandin pathway in human colonic tissue.
COX-2, mPGES-1 and EP2 receptor immunohistochemical expression in canine and feline malignant mammary tumours.
Gastric adenomas: relationship between clinicopathological findings, Helicobacter pylori infection, APC mutations and COX-2 expression.
Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.
Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma.
Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer.
Adenomatous Polyposis Coli
Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer.
Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.
Molecular Targets in Precision Chemoprevention of Colorectal Cancer: An Update from Pre-Clinical to Clinical Trials.
Albuminuria
mPGES-1-derived PGE2 contributes to adriamycin-induced podocyte injury.
Alveolar Bone Loss
Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation.
Alzheimer Disease
Cytosolic prostaglandin E synthase: expression patterns in control and Alzheimer's disease brains.
Elevated microsomal prostaglandin-E synthase-1 in Alzheimer's disease.
Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model.
Microsomal prostaglandin E synthase-2: Cellular distribution and expression in Alzheimer's disease.
The Role of mPGES-1 in Inflammatory Brain Diseases.
[Trends in nonsteroidal anti-inflammatory drug development and application]
Amyotrophic Lateral Sclerosis
Expression of microsomal prostaglandin e synthase-1 in the spinal cord in a transgenic mouse model of amyotrophic lateral sclerosis.
Anemia
Effect of a low dose of dietary resveratrol on colon microbiota, inflammation and tissue damage in a DSS-induced colitis rat model.
Microsomal prostaglandin E synthase 1 deletion retards renal disease progression but exacerbates anemia in mice with renal mass reduction.
Aneurysm
Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation.
Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin.
Aortic Aneurysm
A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine aortic aneurysm model.
Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease.
Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury.
Aortic Aneurysm, Abdominal
Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation.
Apnea
Comparison of cardiorespiratory and EEG abnormalities with seizures in adults and children.
mPGES-1 and Prostaglandin E(2:) vital role in inflammation, hypoxic response, and survival.
Near SUDEP during bilateral stereo-EEG monitoring characterized by diffuse postictal EEG suppression.
The induced prostaglandin E2 pathway is a key regulator of the respiratory response to infection and hypoxia in neonates.
Arthralgia
Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia.
Arthritis
A novel mPGES-1 inhibitor alleviates inflammatory responses by downregulating PGE2 in experimental models.
Anti-inflammatory properties of prostaglandin E2: Deletion of microsomal prostaglandin E synthase-1 exacerbates non-immune inflammatory arthritis in mice.
Aurothiomalate inhibits the expression of mPGES-1 in primary human chondrocytes.
Cloning, expression, and up-regulation of inducible rat prostaglandin e synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis.
Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice.
Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathway.
IL-1?/HMGB1 complexes promote the PGE2 biosynthesis pathway in synovial fibroblasts.
Induction of microsomal prostaglandin E synthase in the rat brain endothelium and parenchyma in adjuvant-induced arthritis.
Inhibition of Matrix Metalloproteinase-3 and -13 Synthesis Induced by IL-1{beta} in Chondrocytes from Mice Lacking Microsomal Prostaglandin E Synthase-1.
Liver X receptor ligands inhibit the lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 and diminish prostaglandin E2 production in murine peritoneal macrophages.
Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model.
Microsomal prostaglandin E synthase-1, ephrins, and ephrin kinases as suspected therapeutic targets in arthritis: exposed by "criminal profiling".
Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2.
mPGES-1 as a novel target for arthritis.
mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis.
Potential roles of microsomal prostaglandin E synthase-1 in rheumatoid arthritis.
Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum-transfer arthritis.
Prostaglandin E synthase in the pathophysiology of arthritis.
Regulation of gene expression by MF63, a selective inhibitor of microsomal PGE synthase 1 (mPGES1) in human osteoarthritic chondrocytes.
Suppressing mPGES-1 expression by sinomenine ameliorates inflammation and arthritis.
Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways.
Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis.
Arthritis, Experimental
Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression.
Anti-inflammatory properties of prostaglandin E2: Deletion of microsomal prostaglandin E synthase-1 exacerbates non-immune inflammatory arthritis in mice.
Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice.
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase.
Prostaglandin E synthase in the pathophysiology of arthritis.
Reduced T cell-dependent humoral immune response in microsomal prostaglandin E synthase-1 null mice is mediated by nonhematopoietic cells.
Arthritis, Rheumatoid
Coexpression of microsomal prostaglandin E synthase with cyclooxygenase-2 in human rheumatoid synovial cells.
Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice.
Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.
Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathway.
Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium.
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase.
Lead Discovery for Microsomal Prostaglandin E Synthase Using a Combination of High-Throughput Fluorescent-Based Assays and RapidFire Mass Spectrometry.
Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells.
Microsomal prostaglandin e synthase-1 in rheumatic diseases.
mPGES-1 deletion affects platelet functions in mice.
Murine mPGES-1 3D structure elucidation and inhibitors binding mode predictions by homology modeling and site-directed mutagenesis.
Potential roles of microsomal prostaglandin E synthase-1 in rheumatoid arthritis.
Prostaglandin E synthase in the pathophysiology of arthritis.
Prostaglandin E2 is an enhancer of interleukin-1beta-induced expression of membrane-associated prostaglandin E synthase in rheumatoid synovial fibroblasts.
Structural basis for induced formation of the inflammatory mediator prostaglandin E2.
Suppressing mPGES-1 expression by sinomenine ameliorates inflammation and arthritis.
Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis.
Asthma
A low dose of Mycoplasma pneumoniae infection enhances an established allergic inflammation in mice: the role of the prostaglandin E pathway.
Common household chemicals and the allergy risks in pre-school age children.
Identification of Four Novel Loci in Asthma in European and African American Populations.
Physiology and pharmacology of prostaglandins.
Selective downregulation of prostaglandin E2-related pathways by the Th2 cytokine IL-13.
Sources of propylene glycol and glycol ethers in air at home.
Astrocytoma
Interleukin-8 (IL-8) overexpression in astrocytomas is induced by prostaglandin E2 (PGE2) and is associated to the transcription factors CCAAT enhancer binding protein-beta (C/EBP-?) and C/EBP Homologous Protein (CHOP).
Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E(2)-dependent activation of type II protein kinase A.
Atherosclerosis
An Update of Microsomal Prostaglandin E Synthase-1 and PGE2 Receptors in Cardiovascular Health and Diseases.
Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice.
Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis.
Inhibitors of the Microsomal Prostaglandin E(2) Synthase-1 as Alternative to Non Steroidal Anti-inflammatory Drugs (NSAIDs) - A Critical Review.
Membrane prostaglandin E synthase-1: a novel therapeutic target.
Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation.
Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease.
Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury.
Molecular docking and competitive binding study discovered different binding modes of microsomal prostaglandin E synthase-1 inhibitors.
Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice.
Myeloid Cell mPges-1 Deletion Attenuates Mortality Without Affecting Remodeling After Acute Myocardial Infarction in Mice.
PGE2, Kidney Disease, and Cardiovascular Risk: Beyond Hypertension and Diabetes.
Prostaglandin E2 synthesis in pigeon aorta: comparison of atherosclerosis-resistant (Show Racer) and atherosclerosis-prone (White Carneau) breeds.
Sex-dependent compensatory mechanisms preserve blood pressure homeostasis in prostacyclin receptor-deficient mice.
Bacterial Infections
An inflammatory pathway to apnea and autonomic dysregulation.
Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice.
Barrett Esophagus
Effect of Proton Pump Inhibitor Therapy on NOX5, mPGES1 and iNOS expression in Barrett's Esophagus.
Bone Diseases
Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation.
Bone Neoplasms
Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice.
Bone Resorption
Aminothiazoles inhibit osteoclastogenesis and PGE2 production in LPS-stimulated co-cultures of periodontal ligament and RAW 264.7 cells, and RANKL-mediated osteoclastogenesis and bone resorption in PBMCs.
Capsaicin, a TRPV1 Ligand, Suppresses Bone Resorption by Inhibiting the Prostaglandin E Production of Osteoblasts, and Attenuates the Inflammatory Bone Loss Induced by Lipopolysaccharide.
Contribution of membrane-associated prostaglandin E2 synthase to bone resorption.
Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E2 synthesis in vitro and ameliorates experimental periodontitis in vivo.
Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation.
Prostaglandin E--a powerful anabolic agent for generalized or site-specific bone formation.
Bradycardia
Comparison of cardiorespiratory and EEG abnormalities with seizures in adults and children.
Brain Concussion
AH6809 decreases production of inflammatory mediators by PGE2 - EP2 - cAMP signaling pathway in an experimentally induced pure cerebral concussion in rats.
Brain Diseases
Postictal stertor: Associations with focal and bilateral seizure types.
The Role of mPGES-1 in Inflammatory Brain Diseases.
Brain Injuries
AH6809 decreases production of inflammatory mediators by PGE2 - EP2 - cAMP signaling pathway in an experimentally induced pure cerebral concussion in rats.
Intracerebral hemorrhage outcomes following selective blockade or stimulation of the PGE2 EP1 receptor.
Brain Ischemia
Prostaglandin E receptors as targets for ischemic stroke: Novel evidence and molecular mechanisms of efficacy.
The role of prostaglandin e2 in stroke-reperfusion injury.
Brain Neoplasms
Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients' survival in glioblastoma multiforme.
Interleukin-8 (IL-8) overexpression in astrocytomas is induced by prostaglandin E2 (PGE2) and is associated to the transcription factors CCAAT enhancer binding protein-beta (C/EBP-?) and C/EBP Homologous Protein (CHOP).
Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets.
Breast Diseases
Microsomal prostaglandin E2 synthase-1 in breast cancer: a potential target for therapy.
Breast Neoplasms
Cigarette Smoke Regulates Calcium-Independent Phospholipase A2 Metabolic Pathways in Breast Cancer.
Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival.
Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis.
Kruppel-like Factor 5 Transcription Factor Promotes Microsomal Prostaglandin E2 Synthase 1 Gene Transcription in Breast Cancer.
Microsomal prostaglandin E2 synthase-1 in breast cancer: a potential target for therapy.
MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer.
Synergistic up-regulation of prostaglandin E synthase expression in breast cancer cells by 17beta-estradiol and proinflammatory cytokines.
Candidiasis
C. albicans activates cyclooxygenase but not its product prostaglandin E? in HPV 16-stabilized cells.
Carcinogenesis
15-Hydroxyprostaglandin dehydrogenase as a marker in colon carcinogenesis: analysis of the prostaglandin pathway in human colonic tissue.
COX-2, mPGES-1 and EP2 receptor immunohistochemical expression in canine and feline malignant mammary tumours.
Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis: ?mplications for cholangiocarcinogenesis.
Expression of COX-2, mPGE-synthase1, MDR-1 (P-gp), and Bcl-xL: a molecular pathway of H pylori-related gastric carcinogenesis.
Expression of microsomal prostaglandin E2 synthase-1 and its role in human hepatocellular carcinoma.
Expression of prostaglandin E synthase in Barrett's cancer.
Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis.
Genetic and epigenetic regulation of the human prostacyclin synthase promoter in lung cancer cell lines.
Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis.
Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice.
Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.
Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1.
Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice.
Hypoxia and prostaglandin E receptor 4 signalling pathways synergise to promote endometrial adenocarcinoma cell proliferation and tumour growth.
Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol.
Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers.
Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer.
Inhibitors of the Microsomal Prostaglandin E(2) Synthase-1 as Alternative to Non Steroidal Anti-inflammatory Drugs (NSAIDs) - A Critical Review.
Interleukin-8 (IL-8) overexpression in astrocytomas is induced by prostaglandin E2 (PGE2) and is associated to the transcription factors CCAAT enhancer binding protein-beta (C/EBP-?) and C/EBP Homologous Protein (CHOP).
Membrane prostaglandin E synthase-1: a novel therapeutic target.
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis.
Microsomal Prostaglandin E Synthase-1 Inhibits PTEN and Promotes Experimental Cholangiocarcinogenesis and Tumor Progression.
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Microsomal Prostaglandin E2 Synthase-1 as a New Macromolecular Drug Target in the Prevention of ?nflammation and Cancer.
Non-cell autonomous effects of targeting inducible PGE2 synthesis during inflammation-associated colon carcinogenesis.
Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis.
Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
Regulation of cyclooxygenase-2 pathway by HER2 receptor.
Role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E2 in colon carcinogenesis.
Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and beta-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice.
Targeted over-expression of mPGES-1 and elevated PGE2 production is not sufficient for lung tumorigenesis in mice.
Toward the discovery of new agents able to inhibit the expression of microsomal prostaglandin E synthase-1 enzyme as promising tools in drug development.
[Role of mPGES-1 in the occurrence, progression, metastasis and invasion of hepatocellular carcinoma].
Carcinoma
COX-2, mPGES-1 and EP2 receptor immunohistochemical expression in canine and feline malignant mammary tumours.
Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal Cancer.
Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis.
Dioscorea japonica extract down-regulates prostaglandin E2 synthetic pathway and induces apoptosis in lung cancer cells.
Ellagitannins from Punica granatum leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis.
Expression of COX-1, COX-2 and mPGES-1 in penile and preputial papillomas and squamous cell carcinomas in the horse.
Expression of cyclooxygenase-2 and microsomal prostagalandin E synthase-1 in head and neck squamous cell carcinoma.
Expression of microsomal prostaglandin E synthase-1 in human hepatocelluar carcinoma.
Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines.
Immunohistochemical Demonstration of Membrane-bound Prostaglandin E(2) Synthase-1 in Papillary Thyroid Carcinoma.
Intersecting Mechanisms of Hypoxia and Prostaglandin E2-Mediated Inflammation in the Comparative Biology of Oral Squamous Cell Carcinoma.
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis.
Microsomal prostaglandin E synthase-1 is overexpressed in head and neck squamous cell carcinoma.
miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells.
Prostaglandin E synthase is upregulated by Gas6 during cancer-induced venous thrombosis.
Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression.
Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx.
The cyclooxygenase-2-mediated prostaglandin signaling is causally related to epithelial carcinogenesis.
Tumor cells induce COX-2 and mPGES-1 expression in microvascular endothelial cells mainly by means of IL-1 receptor activation.
Carcinoma in Situ
Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis.
Carcinoma, Hepatocellular
15d-PGJ? decreases PGE? synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter.
Expression of microsomal prostaglandin E synthase-1 in human hepatocelluar carcinoma.
Expression of microsomal prostaglandin E2 synthase-1 and its role in human hepatocellular carcinoma.
Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/?-catenin signaling axis.
mPGES-1 expression in non-cancerous liver tissue impacts on postoperative recurrence of HCC.
Proteomic Profile of Reversible Protein Oxidation Using PROP, Purification of Reversibly Oxidized Proteins.
Carcinoma, Lewis Lung
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis.
Carcinoma, Non-Small-Cell Lung
Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model.
Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases.
Co-overexpression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 adversely affects the postoperative survival in non-small cell lung cancer.
Dioscorea japonica extract down-regulates prostaglandin E2 synthetic pathway and induces apoptosis in lung cancer cells.
Ellagitannins from Punica granatum leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis.
Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer.
Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells.
miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction.
mPGES-1 as a new target to overcome acquired resistance to gefitinib in non-small cell lung cancer cell lines.
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer.
Carcinoma, Ovarian Epithelial
Ovarian epithelial cancer: a role for PGE2-synthesis and signalling in malignant transformation and progression.
Carcinoma, Squamous Cell
Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis.
Expression of COX-1, COX-2 and mPGES-1 in penile and preputial papillomas and squamous cell carcinomas in the horse.
Microsomal prostaglandin E synthase-1 is overexpressed in head and neck squamous cell carcinoma.
miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells.
Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx.
Cardiomegaly
Lack of microsomal prostaglandin E synthase-1 reduces cardiac function following angiotensin II infusion.
Cardiomyopathies
Microsomal Prostaglandin E2 Synthase-1 Deletion Attenuates Isoproterenol-Induced Myocardial Fibrosis in Mice.
Cardiovascular Diseases
Cyclooxygenase and 5-lipoxygenase pathways in the vessel wall: role in atherosclerosis.
Microsomal Prostaglandin E Synthase-1 Expression by Aortic Smooth Muscle Cells Attenuates the Differentiated Phenotype.
Microsomal Prostaglandin E2 Synthase-1 Deletion Attenuates Isoproterenol-Induced Myocardial Fibrosis in Mice.
Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice.
PGE2, Kidney Disease, and Cardiovascular Risk: Beyond Hypertension and Diabetes.
[Research advances of prostaglandin E2 synthases and receptors in cardiovascular diseases].
Carotid Artery Diseases
Overexpression of COX-2, Prostaglandin E synthase-1 and prostaglandin E receptors in blood mononuclear cells and plaque of patients with carotid atherosclerosis: regulation by nuclear factor-kappaB.
Carotid Stenosis
Overexpression of COX-2, Prostaglandin E synthase-1 and prostaglandin E receptors in blood mononuclear cells and plaque of patients with carotid atherosclerosis: regulation by nuclear factor-kappaB.
Cerebral Cortical Thinning
Cortical thinning in epilepsy patients with postictal generalized electroencephalography suppression.
Cerebral Hemorrhage
A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population.
Cerebral Infarction
Pharmacological and genetic analysis of mechanisms underlying detrusor overactivity in rats.
Chemical and Drug Induced Liver Injury
Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury.
Cholangiocarcinoma
Microsomal Prostaglandin E Synthase-1 Inhibits PTEN and Promotes Experimental Cholangiocarcinogenesis and Tumor Progression.
Cholangitis, Sclerosing
Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis: ?mplications for cholangiocarcinogenesis.
Chorioamnionitis
Differential expression and regulation of microsomal prostaglandin E(2) synthase in human fetal membranes and placenta with infection and in cultured trophoblast cells.
Coinfection
c-Jun N-terminal kinase-mediated stabilization of microsomal prostaglandin E2 synthase-1 mRNA regulates delayed microsomal prostaglandin E2 synthase-1 expression and prostaglandin E2 biosynthesis by cardiomyocytes.
Colitis
Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical inflammasome signaling pathways.
mPGES-1-Mediated Production of PGE2 and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation.
Resolution of Cox mediated inflammation by Se supplementation in mouse experimental model of colitis.
Colonic Neoplasms
15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells.
Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer.
Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells.
Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.
GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells.
Inhibition of microsomal prostaglandin E synthase-1 as targeted therapy in cancer treatment.
Methanolic extract of Boswellia serrata exhibits anti-cancer activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells.
Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis.
Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression.
Sulforaphane, a Chemopreventive Compound, Inhibits Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Expression in Human HT-29 Colon Cancer Cells.
Upregulation of Prostaglandin E2 by Inducible Microsomal Prostaglandin E Synthase-1 in Colon Cancer.
Colorectal Neoplasms
15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells.
Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer.
Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2.
Clinical significance of prostaglandin e synthase expression in colorectal cancer.
Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice.
Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer.
Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer.
Instability of a dinucleotide repeat in the 3'-untranslated region (UTR) of the microsomal prostaglandin E synthase-1 (mPGES-1) gene in microsatellite instability-high (MSI-H) colorectal carcinoma.
Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients.
Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis.
Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression.
[Role of prostaglandins in colon cancer]
[Trends in nonsteroidal anti-inflammatory drug development and application]
Coma
Postictal generalized EEG suppression after generalized convulsive seizures: A double-edged sword.
Corneal Injuries
Expression of microsomal prostaglandin e synthase-1 in fibroblasts of rabbit alkali-burned corneas.
Coronary Occlusion
The effects of microsomal prostaglandin E synthase-1 deletion in acute cardiac ischemia in mice.
Coronary Stenosis
Prostaglandin E2 (PGE2) synthesis pathway is involved in coronary artery stenosis and restenosis.
COVID-19
DREAM-in-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1.
What about COVID-19 and arachidonic acid pathway?
Cysts
Expression of Angiotensin II Types 1 and 2 Receptors in Endometriotic Lesions.
Dehydration
Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus.
Influence of prostaglandins on vasoconstrictor responses in the hindquarters vascular bed of the cat.
mPGES-1-derived PGE2 mediates dehydration natriuresis.
Prostaglandin-macromolecule interactions. I. Noncovalent binding of prostaglandins A1, E1, F2alpha, and E2 by human and bovine serum albumins.
Demyelinating Diseases
Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1? in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis.
Microsomal prostaglandin E synthase-1 aggravates inflammation and demyelination in a mouse model of multiple sclerosis.
Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4? T Cells through IL-1? Autocrine Function in Experimental Autoimmune Encephalomyelitis.
Dermatitis, Contact
Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity.
Dermatomyositis
Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis.
Diabetes Insipidus, Neurogenic
Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus.
Diabetes Mellitus
Influence of a type 2 diabetes associated prostaglandin E synthase 2 polymorphism on blood prostaglandin E2 levels.
mPGES-2 deletion remarkably enhances liver injury in streptozotocin-treated mice via induction of GLUT2.
Diabetes Mellitus, Type 2
Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations.
Influence of a type 2 diabetes associated prostaglandin E synthase 2 polymorphism on blood prostaglandin E2 levels.
Diabetic Retinopathy
Expression of cyclo-oxygenase-2 and downstream enzymes in diabetic fibrovascular epiretinal membranes.
Drug Resistant Epilepsy
An electroclinical case-control study of sudden unexpected death in epilepsy.
Ductus Arteriosus, Patent
Role of microsomal prostaglandin E synthase-1 (mPGES1)-derived PGE2 in patency of the ductus arteriosus in the mouse.
Dyslipidemias
PGE2, Kidney Disease, and Cardiovascular Risk: Beyond Hypertension and Diabetes.
Dyspareunia
Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis.
Eczema
Common household chemicals and the allergy risks in pre-school age children.
Sources of propylene glycol and glycol ethers in air at home.
Encephalomalacia
The effect of Se-deficient diet on gene expression of inflammatory cytokines in chicken brain.
Encephalomyelitis
Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1? in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis.
Microsomal prostaglandin E synthase-1 aggravates inflammation and demyelination in a mouse model of multiple sclerosis.
Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4? T Cells through IL-1? Autocrine Function in Experimental Autoimmune Encephalomyelitis.
Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis.
Encephalomyelitis, Autoimmune, Experimental
Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1? in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis.
Microsomal prostaglandin E synthase-1 aggravates inflammation and demyelination in a mouse model of multiple sclerosis.
Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4? T Cells through IL-1? Autocrine Function in Experimental Autoimmune Encephalomyelitis.
Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis.
Endometriosis
ARID1A, Prostaglandin E2, and Its Receptor as Possible Predictors of Malignant Transformation of the Endometrium in Endometriosis.
Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis.
Expression of eicosanoid biosynthetic and catabolic enzymes in peritoneal endometriosis.
Expression of inducible microsomal prostaglandin E synthase in local lesions of endometriosis patients.
Relationship between Toll-like receptor-4 and mPGES-1 gene expression in local lesions of endometriosis patients.
Stretch magnitude- and frequency-dependent cyclooxygenase 2 and prostaglandin E2 up-regulation in human endometrial stromal cells: possible implications in endometriosis.
The inducible prostaglandin E synthase mPGES-1 regulates growth of endometrial tissues and angiogenesis in a mouse implantation model.
Endometritis
Endometrial expression of selected transcripts in postpartum of primiparous Holstein cows with clinical and subclinical endometritis.
Endometrial expression of selected transcripts involved in prostaglandin synthesis in cows with endometritis.
Evidence for Increased Content of PGF2?, PGE2, and 6-keto-PGF1? in Endometrial Tissue Cultures From Heavy Draft Mares in Anestrus With Endometritis.
Epilepsies, Partial
Postictal generalized EEG suppression is linked to seizure-associated respiratory dysfunction but not postictal apnea.
Epilepsy
Association between semiologic, autonomic, and electrographic seizure characteristics in children with generalized tonic-clonic seizures.
Autonomic dysregulation in children with epilepsy with postictal generalized EEG suppression following generalized convulsive seizures.
Cortical thinning in epilepsy patients with postictal generalized electroencephalography suppression.
Detection of Postictal Generalized Electroencephalogram Suppression: Random Forest Approach.
Nocturnal seizures are associated with more severe hypoxemia and increased risk of postictal generalized EEG suppression.
Periictal electroclinical characteristics of postictal generalized electroencephalographic suppression after generalized convulsive seizures.
Postictal generalized EEG suppression after generalized convulsive seizures: A double-edged sword.
Postictal generalized EEG suppression is not associated with periictal cardiac autonomic instability in people with convulsive seizures.
Postictal generalized electroencephalographic suppression following electroconvulsive therapy: Temporal characteristics and impact of anesthetic regimen.
Postictal generalized electroencephalographic suppression is associated with generalized seizures.
Prevention of sudden unexpected death in epilepsy: current status and future perspectives.
Proteomics and Transcriptomics of the Hippocampus and Cortex in SUDEP and High-Risk SUDEP Patients.
The Role of mPGES-1 in Inflammatory Brain Diseases.
The SUDEP Risk Inventory: Association with postictal generalized EEG suppression.
Tonic phase of a generalized convulsive seizure is an independent predictor of postictal generalized EEG suppression.
Two predictors of postictal generalized EEG suppression: Tonic phase duration and postictal immobility period.
Voltage-based automated detection of postictal generalized electroencephalographic suppression: Algorithm development and validation.
Epilepsy, Temporal Lobe
Postictal generalized EEG suppression after generalized convulsive seizures: A double-edged sword.
Postictal generalized electroencephalographic suppression is associated with generalized seizures.
Epiretinal Membrane
Expression of cyclo-oxygenase-2 and downstream enzymes in diabetic fibrovascular epiretinal membranes.
Erythema
Inflammatory responses of the rabbit eye to prostaglandins.
Local gene expression changes after UV-irradiation of human skin.
Esophageal Neoplasms
Induction of prostaglandin E synthase by gastroesophageal reflux contents in normal esophageal epithelial cells and esophageal cancer cells.
Gastritis
Expression of proteins related to prostaglandin E2 biosynthesis is increased in human gastric cancer and during gastric carcinogenesis.
Microsomal prostaglandin E synthase (mPGES)-1, mPGES-2 and cytosolic PGES expression in human gastritis and gastric ulcer tissue.
The role of cyclooxygenase in gastric mucosal protection.
Gastroesophageal Reflux
Induction of prostaglandin E synthase by gastroesophageal reflux contents in normal esophageal epithelial cells and esophageal cancer cells.
Roles of cyclooxygenase 2 and microsomal prostaglandin E synthase 1 in rat acid reflux oesophagitis.
Gingivitis
The effect of age on prostaglandin-synthesizing enzymes in the development of gingivitis.
Glaucoma
The influence of topical non-steroidal anti-inflammatory drugs on the intraocular pressure lowering effect of topical prostaglandin analogues-A systemic review and meta-analysis.
Glioblastoma
Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients' survival in glioblastoma multiforme.
Glioma
Induction of prostaglandin E2 synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors. Laboratory investigation.
Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1.
Interleukin-8 (IL-8) overexpression in astrocytomas is induced by prostaglandin E2 (PGE2) and is associated to the transcription factors CCAAT enhancer binding protein-beta (C/EBP-?) and C/EBP Homologous Protein (CHOP).
Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E(2)-dependent activation of type II protein kinase A.
The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells.
The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas.
Goiter, Nodular
Expression of prostaglandin E2 and EP receptors in human papillary thyroid carcinoma.
Hamartoma
Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas.
Heart Arrest
Postictal generalized EEG suppression and respiratory dysfunction following generalized tonic-clonic seizures in sleep and wakefulness.
Heart Defects, Congenital
Prostaglandins: a possible regulator of muscle tone in the ductus arteriosus.
Helicobacter Infections
Hyperplastic gastric tumors with spasmolytic polypeptide-expressing metaplasia caused by tumor necrosis factor-alpha-dependent inflammation in cyclooxygenase-2/microsomal prostaglandin E synthase-1 transgenic mice.
Hepatitis
Expression of microsomal prostaglandin E synthase-1 in human hepatocelluar carcinoma.
Hepatitis B
15d-PGJ? decreases PGE? synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter.
Hepatitis, Chronic
mPGES-1 expression in non-cancerous liver tissue impacts on postoperative recurrence of HCC.
Hirschsprung Disease
MPGES-1 derived PGE2 inhibits cell migration by regulating ARP2/3 in the pathogenesis of Hirschsprung disease.
Hydronephrosis
A mouse strain less responsive to dioxin-induced prostaglandin e2 synthesis is resistant to the onset of neonatal hydronephrosis.
Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice.
Predominant role of cytosolic phospholipase A2? in dioxin-induced neonatal hydronephrosis in mice.
Hyperalgesia
A novel role of prostaglandin E2 in neuropathic pain: blockade of microglial migration in the spinal cord.
Downregulation of cytosolic prostaglandin E2 synthase results in decreased nociceptive behavior in rats.
Expression of mPGES-1 and IP mRNA is reduced by LLLT in both subplantar and brain tissues in the model of peripheral inflammation induced by carrageenan.
Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS.
MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.
Relevance of prostaglandins in migraine.
Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model.
Hypercholesterolemia
Down-regulation of microsomal prostaglandin E2 synthase-1 in the infrapatellar fat pad of osteoarthritis patients with hypercholesterolemia.
Hyperlipidemias
Sex-dependent compensatory mechanisms preserve blood pressure homeostasis in prostacyclin receptor-deficient mice.
Hypernatremia
mPGES-1 Deletion Impairs Aldosterone Escape and Enhances Sodium Appetite.
Hypersensitivity
Dose-dependent acute liver injury with hypersensitivity features in humans due to a novel microsomal prostaglandin E synthase 1 inhibitor.
Platinum group elements in the environment: emissions and exposure.
Prostaglandin E2 Produced by the Lung Augments the Effector Phase of Allergic Inflammation.
Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1.
The metallobiochemistry of ultratrace levels of platinum group elements in the rat.
Hypertension
Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1.
Deletion of microsomal prostaglandin E synthase-1 increases sensitivity to salt loading and angiotensin II infusion.
Lack of microsomal prostaglandin E synthase-1 reduces cardiac function following angiotensin II infusion.
Microsomal prostaglandin E synthase-1 and blood pressure regulation.
Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury.
mPGES-1 (Microsomal Prostaglandin E Synthase-1) Mediates Vascular Dysfunction in Hypertension Through Oxidative Stress.
mPGES-1 protects against DOCA-salt hypertension via inhibition of oxidative stress or stimulation of NO/cGMP.
Myeloid Cell mPges-1 Deletion Attenuates Mortality Without Affecting Remodeling After Acute Myocardial Infarction in Mice.
Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin.
PGE2, Kidney Disease, and Cardiovascular Risk: Beyond Hypertension and Diabetes.
Pulmonary and cardiorenal cyclooxygenase-1 (COX-1), -2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1) and -2 (mPGES-2) expression in a hypertension model.
Regulation of YAP by Mammalian Target of Rapamycin Complex 1 in Endothelial Cells Controls Blood Pressure Through COX-2/mPGES-1/PGE2 Cascade.
Hypertension, Renovascular
Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat).
Hypotension
Release of a prostaglandin E-like substance into mixed venous blood during endotoxin hypotension in cats.
Significant postictal hypotension: Expanding the spectrum of seizure-induced autonomic dysregulation.
Idiopathic Pulmonary Fibrosis
Microsomal prostaglandin E synthase-1 deficiency exacerbates pulmonary fibrosis induced by bleomycin in mice.
Infections
15d-PGJ? decreases PGE? synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter.
Blood COX-2 and PGES gene transcription during the peripartum period of dairy cows with normal puerperium or with uterine infection.
BVDV alters uterine prostaglandin production during pregnancy recognition in cows.
c-Jun N-terminal kinase-mediated stabilization of microsomal prostaglandin E2 synthase-1 mRNA regulates delayed microsomal prostaglandin E2 synthase-1 expression and prostaglandin E2 biosynthesis by cardiomyocytes.
Differential expression and regulation of microsomal prostaglandin E(2) synthase in human fetal membranes and placenta with infection and in cultured trophoblast cells.
EP2/4 Receptors Promote the Synthesis of PGE2 Increasing Tissue Damage in Bovine Endometrial Explants Induced by Escherichia coli.
Evidence in Favor of an Alternative Glucocorticoid Synthesis Pathway During Acute Experimental Chagas Disease.
Gastric adenomas: relationship between clinicopathological findings, Helicobacter pylori infection, APC mutations and COX-2 expression.
IL-1beta treatment does not co-ordinately up-regulate mPGES-1 and COX-2 mRNA expression, but results in higher degree of cellular and intracellular co-localization of their immunoreactive proteins in human placenta trophoblast cells.
Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice.
Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death.
Targeting eicosanoid pathways in the development of novel anti-influenza drugs.
The prostaglandin E2 receptor EP4 is integral to a positive feedback loop for prostaglandin E2 production in human macrophages infected with Mycobacterium tuberculosis.
The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.
The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone induces cyclooxygenase-2 and prostaglandin E2 production in human lung fibroblasts: implications for inflammation.
Upregulation of Cytokines and Differentiation of Th17 and Treg by Dendritic Cells: Central Role of Prostaglandin E2 Induced by Mycobacterium bovis.
Infertility
Comparative study of antiinflammatory drugs and sulphasalazine in relation to prostaglandin E and 19 hydroxylated prostaglandin E levels and human male fertility.
Microsomal prostaglandin E synthase-1 (mPGES-1) is the primary form of PGES expressed by the primate periovulatory follicle.
Prostaglandin concentrations in the semen of fertile men.
Inflammatory Bowel Diseases
Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1.
Withdrawal: Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease: Evidence for involvement of the transcription factor Egr-1.
Influenza, Human
Identification of novel membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitors with anti-influenza activities in vitro.
Intellectual Disability
The SUDEP Risk Inventory: Association with postictal generalized EEG suppression.
Intestinal Neoplasms
Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.
Non-cell autonomous effects of targeting inducible PGE2 synthesis during inflammation-associated colon carcinogenesis.
Intracranial Aneurysm
Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin.
PGE(2) -EP(2) receptor signaling in endothelium is activated by hemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-?B.
Upregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary results.
Ischemic Stroke
A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population.
The Role of mPGES-1 in Inflammatory Brain Diseases.
Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
Kidney Diseases
PGE2, Kidney Disease, and Cardiovascular Risk: Beyond Hypertension and Diabetes.
Kidney Failure, Chronic
Microsomal prostaglandin E synthase 1 deletion retards renal disease progression but exacerbates anemia in mice with renal mass reduction.
Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification.
Prostaglandin E2 receptor EP2 mediates the effect of cyclooxygenase 2 on secondary parathyroid hyperplasia in end-stage renal disease.
Laryngeal Neoplasms
Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx.
Leukemia
MK886 inhibits the proliferation of HL-60 leukemia cells by suppressing the expression of mPGES-1 and reducing prostaglandin E2 synthesis.
[Effect of mPGES-1 Inhibitor MK886 on Apoptosis and Drug Resistance of HL-60/A Cells].
[Effect of mPGES-1 inhibitor MK886 on cell cycle of leukemia HL-60 cells].
[Effects of shRNA Targeting mPGES-1 on Tumorigenicity of K562 Cells in Nude Mice In Vivo].
Leukemia, Myeloid, Acute
MK886 inhibits the proliferation of HL-60 leukemia cells by suppressing the expression of mPGES-1 and reducing prostaglandin E2 synthesis.
[Effect of mPGES-1 inhibitor MK886 on cell cycle of leukemia HL-60 cells].
Leydig Cell Tumor
COX-2 gene polymorphisms and protein expression in renomedullary interstitial cell tumors.
Liver Diseases
Pathophysiological role of prostaglandin E synthases in liver diseases.
Liver Neoplasms
Expression of microsomal prostaglandin E2 synthase-1 and its role in human hepatocellular carcinoma.
Long QT Syndrome
Prevention of sudden unexpected death in epilepsy: current status and future perspectives.
Lung Injury
Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice.
Lung Neoplasms
Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model.
Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases.
Clinical implications of microsomal prostaglandin e synthase-1 overexpression in human non-small-cell lung cancer.
Co-overexpression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 adversely affects the postoperative survival in non-small cell lung cancer.
Ellagitannins from Punica granatum leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis.
Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis.
Genetic and epigenetic regulation of the human prostacyclin synthase promoter in lung cancer cell lines.
Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer.
Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells.
Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells.
miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction.
miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells.
miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells.
mPGES-1 as a new target to overcome acquired resistance to gefitinib in non-small cell lung cancer cell lines.
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer.
Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells.
Revealing the effect of 6-gingerol, 6-shogaol and curcumin on mPGES-1, GSK-3? and ?-catenin pathway in A549 cell line.
Stabilization of PTGES by deubiquitinase USP9X promotes metastatic features of lung cancer via PGE2 signaling.
Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway.
Lymphatic Metastasis
PGE2 signaling and its biosynthesis-related enzymes in cholangiocarcinoma progression.
Lymphoma
Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma.
Medulloblastoma
Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets.
Melanoma
Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression.
The COX2 Effector Microsomal PGE2 Synthase 1 is a Regulator of Immunosuppression in Cutaneous Melanoma.
Melanoma, Experimental
Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis.
Metabolic Syndrome
PGE2, Kidney Disease, and Cardiovascular Risk: Beyond Hypertension and Diabetes.
Prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism and parameters of the metabolic syndrome.
Miosis
Atropine-antagonized miosis induced in the goat by intravenous infusions of prostaglandin E (PGE1 and PGE2).
Mucositis
Role of the cyclooxygenase pathway in chemotherapy-induced oral mucositis: a pilot study.
Multiple Sclerosis
Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1? in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis.
Microsomal prostaglandin E synthase-1 aggravates inflammation and demyelination in a mouse model of multiple sclerosis.
Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4? T Cells through IL-1? Autocrine Function in Experimental Autoimmune Encephalomyelitis.
Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis.
Myocardial Infarction
An Update of Microsomal Prostaglandin E Synthase-1 and PGE2 Receptors in Cardiovascular Health and Diseases.
Comparison of microsomal prostaglandin E synthase-1 deletion and COX-2 inhibition in acute cardiac ischemia in mice.
Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction.
Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction.
Myeloid Cell mPges-1 Deletion Attenuates Mortality Without Affecting Remodeling After Acute Myocardial Infarction in Mice.
Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
Myositis
Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis.
Microsomal prostaglandin e synthase-1 in rheumatic diseases.
Nasal Polyps
Role of prostaglandin D2 and E2 terminal synthases in chronic rhinosinusitis.
Neoplasm Metastasis
Clinical implications of microsomal prostaglandin e synthase-1 overexpression in human non-small-cell lung cancer.
Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis.
Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis.
Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis.
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis.
Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow.
mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity.
PGE2 signaling and its biosynthesis-related enzymes in cholangiocarcinoma progression.
PTGES/PGE2 signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model.
Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells.
Stabilization of PTGES by deubiquitinase USP9X promotes metastatic features of lung cancer via PGE2 signaling.
[Role of mPGES-1 in the occurrence, progression, metastasis and invasion of hepatocellular carcinoma].
Neoplasms
15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells.
15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice.
15d-PGJ? decreases PGE? synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter.
A study of prostaglandin E2, parathormone, and response to indomethacin in patients with hypercalcemia of malignancy.
AH6809 decreases production of inflammatory mediators by PGE2 - EP2 - cAMP signaling pathway in an experimentally induced pure cerebral concussion in rats.
Allogenic Pure Platelet-Rich Plasma Therapy for Adhesive Capsulitis: A Bed-to-Bench Study With Propensity Score Matching Using a Corticosteroid Control Group.
Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.
Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway.
Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation.
Arsenic-induced testicular toxicity in Gallus gallus: Expressions of inflammatory cytokines and heat shock proteins.
Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer.
Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1.
Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway.
Characterization of microsomal prostaglandin E synthase 1 inhibitors.
Chemoprevention of urothelial cell carcinoma growth and invasion by the dual COX-LOX inhibitor licofelone in UPII-SV40T transgenic mice.
Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer.
Clinical data mining reveals analgesic effects of lapatinib in cancer patients.
Clinical implications of microsomal prostaglandin e synthase-1 overexpression in human non-small-cell lung cancer.
Clinical significance of prostaglandin E synthase expression in gastric cancer tissue.
Co-overexpression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 adversely affects the postoperative survival in non-small cell lung cancer.
Comparative Analysis of Peritoneum and Tumor Eicosanoids and Pathways in Advanced Ovarian Cancer.
Conditioned media from adipose-tissue-derived mesenchymal stem cells downregulate degradative mediators induced by interleukin-1? in osteoarthritic chondrocytes.
Contribution of membrane-associated prostaglandin E2 synthase to bone resorption.
Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.
Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4.
Corticosterone suppresses IL-1?-induced mPGE2 expression through regulation of the 11?-HSD1 bioactivity of synovial fibroblasts in vitro.
COX-2 gene polymorphisms and protein expression in renomedullary interstitial cell tumors.
COX-2 Limits Prostanoid Production in Activated HUVECs and Is a Source of PGH2 for Transcellular Metabolism to PGE2 by Tumor Cells.
COX-2 signaling and cancer: new players in old arena.
COX-2, mPGES-1 and EP2 receptor immunohistochemical expression in canine and feline malignant mammary tumours.
COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset.
CRISPR/Cas9-based liver-derived reporter cells for screening of mPGES-1 inhibitors.
Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal Cancer.
Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis.
Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE2 synthesis by inhibiting mPGES-1 activity.
Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2.
Dimethylcelecoxib inhibits mPGES-1 promoter activity by influencing EGR1 and NF-?B.
Dioscorea japonica extract down-regulates prostaglandin E2 synthetic pathway and induces apoptosis in lung cancer cells.
Discovery of 3-hydroxy-3-pyrrolin-2-one-based mPGES-1 inhibitors using a multi-step virtual screening protocol.
Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol.
Does dienogest influence the inflammatory response of endometriotic cells? A systematic review.
Down-regulation of microsomal prostaglandin E2 synthase-1 in the infrapatellar fat pad of osteoarthritis patients with hypercholesterolemia.
Effect of sphingosine kinase 1 inhibition on blood pressure.
Effect of vitamin C on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated early colon cancer in mice.
Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathway.
Effects of Excess Manganese on the Oxidative Status, and the Expression of Inflammatory Factors and Heat Shock Proteins in Cock Kidneys.
EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity.
Ellagitannins from Punica granatum leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis.
Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2.
Enhancement of antitumor activity of docetaxel by celecoxib in lung tumors.
Enriched environment housing improved the laying hen's resistance to transport stress via modulating the heat shock protective response and inflammation.
Establishment of an in vitro 3D model for neuroblastoma enables preclinical investigation of combined tumor-stroma drug targeting.
Expression and contribution of three different isoforms of prostaglandin E synthase in the bovine endometrium.
Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes.
Expression of cyclo-oxygenase 1 and 2, prostaglandin E synthase and transforming growth factor beta1, and their relationship with vascular endothelial growth factors A and C, in primary adenocarcinoma of the small intestine.
Expression of cyclooxygenase-1/-2, microsomal prostaglandin-E synthase-1 and E-prostanoid receptor 2 and regulation of inflammatory mediators by PGE(2) in the amoeboid microglia in hypoxic postnatal rats and murine BV-2 cells.
Expression of cyclooxygenase-2 and microsomal prostagalandin E synthase-1 in head and neck squamous cell carcinoma.
Expression of cyclooxygenase-2 and microsomal prostaglandin-E synthase in amoeboid microglial cells in the developing brain and effects of cyclooxygenase-2 neutralization on BV-2 microglial cells.
Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis.
Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines.
Expression of microsomal prostaglandin E2 synthase-1 and its role in human hepatocellular carcinoma.
Expression of prostaglandin E synthase in Barrett's cancer.
Expression of prostaglandin e synthases in periodontitis immunolocalization and cellular regulation.
Expression of prostaglandin E2 and EP receptors in human papillary thyroid carcinoma.
Expression of proteins related to prostaglandin E2 biosynthesis is increased in human gastric cancer and during gastric carcinogenesis.
Gene expression profiles of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy.
Genes for prostaglandin synthesis, transport and inactivation are differentially expressed in human uterine tissues, and the prostaglandin F synthase AKR1B1 is induced in myometrial cells by inflammatory cytokines.
Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis.
Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice.
Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.
Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1.
GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1?/IL1R1 response.
Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes.
Hyperplastic gastric tumors with spasmolytic polypeptide-expressing metaplasia caused by tumor necrosis factor-alpha-dependent inflammation in cyclooxygenase-2/microsomal prostaglandin E synthase-1 transgenic mice.
Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis.
Hypoxia-inducible factor-2? is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer.
ICV vs. VMH injection of leptin: comparative effects on hypothalamic gene expression.
Identification and development of mPGES-1 inhibitors: where we are at?
Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition.
Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers.
Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target.
Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening.
Identification of novel mPGES-1 inhibitors through screening of a chemical library.
Immunohistochemical Demonstration of Membrane-bound Prostaglandin E(2) Synthase-1 in Papillary Thyroid Carcinoma.
Immunohistochemical Expression of COX-2, mPGES and EP2 Receptor in Normal and Reactive Canine Bone and in Canine Osteosarcoma.
Impact of Cyclooxygenase-2 1195 G-Carrier Genotype Associated with Intestinal Metaplasia and Endoscopic Findings Based on Kyoto Classification.
Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer.
Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients' survival in glioblastoma multiforme.
Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats.
Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer.
Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer.
Induction of human microsomal prostaglandin E synthase 1 by activated oncogene RhoA GTPase in A549 human epithelial cancer cells.
Induction of prostaglandin E2 pathway promotes gastric hamartoma development with suppression of bone morphogenetic protein signaling.
Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures.
Inflammatory and oxidative mechanisms potentiate bifenthrin-induced neurological alterations and anxiety-like behavior in adult rats.
Inhibition of hypoxia inducible factor-1alpha by dihydroxyphenylethanol, a product from olive oil, blocks microsomal prostaglandin-E synthase-1/vascular endothelial growth factor expression and reduces tumor angiogenesis.
Inhibition of IFN-gamma induction of class II MHC genes by cAMP and prostaglandins.
Inhibition of microsomal prostaglandin E synthase-1 as targeted therapy in cancer treatment.
Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth.
Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells.
Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy.
Instability of a dinucleotide repeat in the 3'-untranslated region (UTR) of the microsomal prostaglandin E synthase-1 (mPGES-1) gene in microsatellite instability-high (MSI-H) colorectal carcinoma.
Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2.
Interleukin-8 (IL-8) overexpression in astrocytomas is induced by prostaglandin E2 (PGE2) and is associated to the transcription factors CCAAT enhancer binding protein-beta (C/EBP-?) and C/EBP Homologous Protein (CHOP).
Intersecting Mechanisms of Hypoxia and Prostaglandin E2-Mediated Inflammation in the Comparative Biology of Oral Squamous Cell Carcinoma.
Kruppel-like Factor 5 Transcription Factor Promotes Microsomal Prostaglandin E2 Synthase 1 Gene Transcription in Breast Cancer.
Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostate cancer.
Linking of mPGES-1 and iNOS activates stem-like phenotype in EGFR-driven epithelial tumor cells.
Lipopolysaccharides, cytokines, and nitric oxide affect secretion of prostaglandins and leukotrienes by bovine mammary gland epithelial cells.
Localization of prostaglandin E2 synthases and E-prostanoid receptors in the spinal cord in a rat model of neuropathic pain.
Loss of 15-Hydroxyprostaglandin Dehydrogenase Increases Prostaglandin E2 in Pancreatic Tumors.
Loss of natural killer T cells promotes pancreatic cancer in LSL-Kras(G12D/+) mice.
Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2.
Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis.
Microsomal prostaglandin E synthase 1 deletion retards renal disease progression but exacerbates anemia in mice with renal mass reduction.
Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells.
Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients.
Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer.
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis.
Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease.
Microsomal Prostaglandin E Synthase-1 Inhibits PTEN and Promotes Experimental Cholangiocarcinogenesis and Tumor Progression.
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1.
Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/?-catenin signaling axis.
Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow.
Microsomal Prostaglandin E2 Synthase-1 as a New Macromolecular Drug Target in the Prevention of ?nflammation and Cancer.
Microsomal prostaglandin E2 synthase-1 in breast cancer: a potential target for therapy.
Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.
Microsomal prostaglandin E2 synthase-1 is induced by conditional expression of RET/PTC in thyroid PCCL3 cells through the activation of the MEK-ERK pathway.
miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction.
miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells.
miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells.
MK886 inhibits the proliferation of HL-60 leukemia cells by suppressing the expression of mPGES-1 and reducing prostaglandin E2 synthesis.
Modulation of inflammatory response by selective inhibition of cyclooxygenase-1 and cyclooxygenase-2 in acute kidney injury.
Molecular docking and competitive binding study discovered different binding modes of microsomal prostaglandin E synthase-1 inhibitors.
Molecular Targets in Precision Chemoprevention of Colorectal Cancer: An Update from Pre-Clinical to Clinical Trials.
mPGES-1 as a novel target for arthritis.
mPGES-1 as a target for cancer suppression A comprehensive invited review "Phospholipase A(2) and lipid mediators"
mPGES-1 expression in non-cancerous liver tissue impacts on postoperative recurrence of HCC.
mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity.
MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer.
mPGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice.
Multifaceted roles of PGE2 in inflammation and cancer.
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer.
Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation.
NF-kappaB induces PGE(2)-synthesizing enzymes in neurons.
Nitric Oxide and PGE-2 Cross-Talk in EGFR-Driven Epithelial Tumor Cells.
Non-cell autonomous effects of targeting inducible PGE2 synthesis during inflammation-associated colon carcinogenesis.
Nonsteroidal anti-inflammatory drug-activated gene-1 expression inhibits urethane-induced pulmonary tumorigenesis in transgenic mice.
Ovarian epithelial cancer: a role for PGE2-synthesis and signalling in malignant transformation and progression.
Oxytocin and tumor necrosis factor alpha stimulate expression of prostaglandin E2 synthase and secretion of prostaglandin E2 by luminal epithelial cells of the porcine endometrium during early pregnancy.
Peripheral lipopolysaccharide administration induces cytokine mRNA expression in the viscera and brain of fever-refractory mice lacking microsomal prostaglandin E synthase-1.
PGE2 signaling and its biosynthesis-related enzymes in cholangiocarcinoma progression.
Pharmacological inhibition of microsomal prostaglandin e synthase-1 suppresses epidermal growth factor receptor-mediated tumor growth and angiogenesis.
Phosphodiesterase 4A confers resistance to PGE2-mediated suppression in CD25+ /CD54+ NK cells.
Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis.
Progranulin Protects Hippocampal Neurogenesis via Suppression of Neuroinflammatory Responses Under Acute Immune Stress.
Prostaglandin e synthase: a novel drug target for inflammation and cancer.
Prostaglandin E2 produced by inducible COX-2 and mPGES-1 promoting cancer cell proliferation in vitro and in vivo.
Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization.
Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
Prostaglandins in cancer cell adhesion, migration, and invasion.
Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression.
Receptor and enzyme expression for prostanoid metabolism in colorectal cancer related to tumor tissue PGE2.
Regulation of Human Microsomal Prostaglandin E Synthase-1 by IL-1? requires a Distal Enhancer Element with a Unique Role for C/EBP?
Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2.
Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2.
Regulation of the prostaglandin pathway during development of invasive bladder cancer in mice.
Regulatory roles of PGE2 in LPS-induced tissue damage in bovine endometrial explants.
Revealing the effect of 6-gingerol, 6-shogaol and curcumin on mPGES-1, GSK-3? and ?-catenin pathway in A549 cell line.
Role of TLR-4 in liver macrophage and endothelial cell responsiveness during acute endotoxemia.
Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells.
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
Selective PGE2 Suppression Inhibits Colon Carcinogenesis and Modifies Local Mucosal Immunity.
Selenium alleviates cadmium-induced inflammation and meat quality degradation via antioxidant and anti-inflammation in chicken breast muscles.
Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts.
Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx.
Sonlicromanol's active metabolite KH176m normalizes prostate cancer stem cell mPGES-1 overexpression and inhibits cancer spheroid growth.
Stabilization of PTGES by deubiquitinase USP9X promotes metastatic features of lung cancer via PGE2 signaling.
Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport.
Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1.
Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase.
Targeted over-expression of mPGES-1 and elevated PGE2 production is not sufficient for lung tumorigenesis in mice.
Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE2 Levels.
Tenacissoside H exerts an anti-inflammatory effect by regulating the nf-?b and p38 pathways in zebrafish.
The Antagonistic Effect of Selenium on Cadmium-Induced Damage and mRNA Levels of Selenoprotein Genes and Inflammatory Factors in Chicken Kidney Tissue.
The COX2 Effector Microsomal PGE2 Synthase 1 is a Regulator of Immunosuppression in Cutaneous Melanoma.
The cyclooxygenase-2-mediated prostaglandin signaling is causally related to epithelial carcinogenesis.
The role of heat shock protein 70 in oxidant stress and inflammatory injury in quail spleen induced by cold stress.
The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas.
Transcriptional regulation of microsomal prostaglandin E synthase 1 by the proto-oncogene, c-myc, in the pathogenesis of inflammation and cancer.
Transcriptional regulation of mPGES1 in Cancer: an alternative approach to drug discovery?
Triclosan reduces microsomal prostaglandin E synthase-1 expression in human gingival fibroblasts.
Tumor cells induce COX-2 and mPGES-1 expression in microvascular endothelial cells mainly by means of IL-1 receptor activation.
[Prostaglandin E2 synthases]
[Role of mPGES-1 in the occurrence, progression, metastasis and invasion of hepatocellular carcinoma].
Neuralgia
Localization of prostaglandin E2 synthases and E-prostanoid receptors in the spinal cord in a rat model of neuropathic pain.
Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain.
Neuroblastoma
Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1.
COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset.
Establishment of an in vitro 3D model for neuroblastoma enables preclinical investigation of combined tumor-stroma drug targeting.
Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth.
Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols.
Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport.
Targeting mPGES-1 as a New Strategy against Neuroblastoma.
Targeting the COX/mPGES-1/PGE2 Pathway in Neuroblastoma.
Neurodegenerative Diseases
Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease.
Neuroinflammatory Diseases
Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation.
Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: Possible involvement of NF-?B and p38 MAPK inhibition.
CCAAT/Enhancer binding protein ? regulates prostaglandin E synthase expression and prostaglandin E2 production in activated microglial cells.
Impaired lipid metabolism markers to assess the risk of neuroinflammation in autism spectrum disorder.
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells.
Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2.
Roles of prostaglandin synthesis in excitotoxic brain diseases.
Obesity
Down-regulation of microsomal prostaglandin E2 synthase-1 in adipose tissue by high-fat feeding.
Invalidation of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Reduces Diet-Induced Low-Grade Inflammation and Adiposity.
Prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism and parameters of the metabolic syndrome.
Obstetric Labor, Premature
Change in prostaglandin E synthases (PGESs) in microsomal PGES-1 knockout mice in a preterm delivery model.
Differential expression and regulation of microsomal prostaglandin E(2) synthase in human fetal membranes and placenta with infection and in cultured trophoblast cells.
Expression and localization of prostaglandin E synthase isoforms in human fetal membranes in term and preterm labor.
Odontogenic Cysts
Odontogenic cyst growth and prostaglandin-induced bone resorption.
Oligodendroglioma
The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas.
Osteoarthritis
A randomized clinical efficacy study targeting mPGES1 or EP4 in dogs with spontaneous osteoarthritis.
Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders.
BCP crystals increase prostacyclin production and upregulate the prostacyclin receptor in OA synovial fibroblasts: potential effects on mPGES1 and MMP-13.
Corticosterone suppresses IL-1?-induced mPGE2 expression through regulation of the 11?-HSD1 bioactivity of synovial fibroblasts in vitro.
Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.
Down-regulation of microsomal prostaglandin E2 synthase-1 in the infrapatellar fat pad of osteoarthritis patients with hypercholesterolemia.
Eicosanoids, osteoarthritis, and crystal deposition diseases.
Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis.
Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1?-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes.
Mechanical stress and prostaglandin E(2) synthesis in cartilage.
Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis.
Microsomal prostaglandin e synthase-1 in rheumatic diseases.
Prostaglandin E synthase in the pathophysiology of arthritis.
Prostaglandin e2 synthase-1 inhibitors as potential treatment for osteoarthritis: patent highlight.
Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene.
Regulation of gene expression by MF63, a selective inhibitor of microsomal PGE synthase 1 (mPGES1) in human osteoarthritic chondrocytes.
Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways.
Osteolysis
A mutation of cysteine 46 in IKK-? promotes mPGES-1 and caveolin-1 expression to exacerbate osteoclast differentiation and osteolysis.
Osteosarcoma
Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells.
Immunohistochemical Expression of COX-2, mPGES and EP2 Receptor in Normal and Reactive Canine Bone and in Canine Osteosarcoma.
Ovarian Neoplasms
Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis.
Pancreatic Neoplasms
Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers.
Papilloma
Elevated prostaglandin E2 level via cPLA2--COX-2--mPGES-1 pathway involved in bladder carcinogenesis induced by terephthalic acid-calculi in Wistar rats.
Expression of COX-1, COX-2 and mPGES-1 in penile and preputial papillomas and squamous cell carcinomas in the horse.
The expression pattern of prostaglandin E synthase and EP receptor isoforms in normal mouse skin and preinvasive skin neoplasms.
Paralysis
Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1? in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis.
Parkinson Disease
Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease.
Pellagra
Niacin deficiency and cutaneous immunity.
Prostaglandin E? is critical for the development of niacin-deficiency-induced photosensitivity via ROS production.
Periodontitis
Expression of prostaglandin e synthases in periodontitis immunolocalization and cellular regulation.
Inhibition of microsomal prostaglandin E synthase-1 by aminothiazoles decreases prostaglandin E2 synthesis in vitro and ameliorates experimental periodontitis in vivo.
Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation.
Peripheral Nerve Injuries
A novel role of prostaglandin E2 in neuropathic pain: blockade of microglial migration in the spinal cord.
Peritoneal Fibrosis
Enhanced mPGES-1 Contributes to PD-Related Peritoneal Fibrosis via Activation of the NLRP3 Inflammasome.
Peritonitis
Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression.
Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model.
Pleurisy
Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.
Interaction between cyclooxygenase (COX)-1- and COX-2-products modulates COX-2 expression in the late phase of acute inflammation.
Pneumonia
Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer.
DREAM-in-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1.
Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation.
Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes.
Pneumonia, Bacterial
Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice.
Pneumonia, Pneumococcal
Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice.
Polymyositis
Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis.
Polyuria
Mice Lacking mPGES-1 Are Resistant to Lithium-Induced Polyuria.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Regulation of mPGES-1 composition and cell growth via the MAPK signaling pathway in jurkat cells.
prostaglandin-e synthase deficiency
Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders.
Deletion of microsomal prostaglandin E synthase-1 increases sensitivity to salt loading and angiotensin II infusion.
Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile.
Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis.
Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.
Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1.
Involvement of prostacyclin synthase in high-fat-diet-induced obesity.
Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation.
Microsomal prostaglandin E synthase-1 deficiency exacerbates pulmonary fibrosis induced by bleomycin in mice.
Microsomal prostaglandin E synthase-1 deficiency is associated with elevated peroxisome proliferator-activated receptor gamma: regulation by prostaglandin E2 via the phosphatidylinositol 3-kinase and Akt pathway.
Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen.
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Non-cell autonomous effects of targeting inducible PGE2 synthesis during inflammation-associated colon carcinogenesis.
Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin.
Reduced T cell-dependent humoral immune response in microsomal prostaglandin E synthase-1 null mice is mediated by nonhematopoietic cells.
Role of microsomal prostaglandin E synthase 1 in the kidney.
The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background.
prostaglandin-endoperoxide synthase deficiency
Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-kappa B pathway and downstream enzymes involved in prostaglandin biosynthesis.
prostaglandin-i synthase deficiency
Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1.
Prostatic Hyperplasia
Expression and significance of microsomal prostaglandin synthase-1 (mPGES-1) and Beclin-1 in the development of prostate cancer.
Prostatic Neoplasms
Expression and significance of microsomal prostaglandin synthase-1 (mPGES-1) and Beclin-1 in the development of prostate cancer.
Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostate cancer.
Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells.
Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow.
mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity.
Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation.
Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells.
Sonlicromanol's active metabolite KH176m normalizes prostate cancer stem cell mPGES-1 overexpression and inhibits cancer spheroid growth.
Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport.
Prostatitis
Prostaglandin levels in infertile patients affected by asthenozoospermia and prostatitis.
Proteinuria
COX-2 but not mPGES-1 contributes to renal PGE2 induction and diabetic proteinuria in mice with type-1 diabetes.
Psoriasis
Co-localization of COX-2, CYP4F8, and mPGES-1 in epidermis with prominent expression of CYP4F8 mRNA in psoriatic lesions.
Pulmonary Disease, Chronic Obstructive
The cyclooxygenase-2-prostaglandin e2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts.
Pulmonary Fibrosis
Microsomal prostaglandin E synthase-1 deficiency exacerbates pulmonary fibrosis induced by bleomycin in mice.
Pyometra
Identifying diagnostic endocrine markers and changes in endometrial gene expressions during pyometra in cats.
Positive correlation between patency and mRNA levels for cyclooxygenase-2 and prostaglandin E synthase in the uterine cervix of bitches with pyometra.
Prostaglandin synthesis genes are differentially transcripted in normal and pyometra endometria of bitches.
Radicular Cyst
Odontogenic cyst growth and prostaglandin-induced bone resorption.
Renal Insufficiency
Involvement of endogenous prostaglandin E2 in tubular epithelial regeneration through inhibition of apoptosis and epithelial-mesenchymal transition in cisplatin-induced rat renal lesions.
Renal Insufficiency, Chronic
Dual role of microsomal prostaglandin E synthase 1 in chronic kidney disease.
Respiratory Hypersensitivity
Deletion of Microsomal Prostaglandin E Synthase-1 Does Not Alter Ozone-induced Airway Hyper-responsiveness.
Respiratory Insufficiency
Postictal generalized EEG suppression is linked to seizure-associated respiratory dysfunction but not postictal apnea.
Rheumatic Diseases
Microsomal prostaglandin e synthase-1 in rheumatic diseases.
Rhinitis
Common household chemicals and the allergy risks in pre-school age children.
Sources of propylene glycol and glycol ethers in air at home.
Sarcoma
Molecular Targets in Precision Chemoprevention of Colorectal Cancer: An Update from Pre-Clinical to Clinical Trials.
Scleroderma, Systemic
mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis.
Seizures
Age-specific periictal electroclinical features of generalized tonic-clonic seizures and potential risk of sudden unexpected death in epilepsy (SUDEP).
An electroclinical case-control study of sudden unexpected death in epilepsy.
Association between semiologic, autonomic, and electrographic seizure characteristics in children with generalized tonic-clonic seizures.
Automated Analysis of Risk Factors for Postictal Generalized EEG Suppression.
Automated Detection of Postictal Generalized EEG Suppression.
Automated Video Detection of Epileptic Convulsion Slowing as a Precursor for Post-Seizure Neuronal Collapse.
Categorisation of EEG suppression using enhanced feature extraction for SUDEP risk assessment.
Characteristics of postictal generalized EEG suppression in children.
Comparison of cardiorespiratory and EEG abnormalities with seizures in adults and children.
Cortical thinning in epilepsy patients with postictal generalized electroencephalography suppression.
Cross-Frequency Coupling Features of Postictal Generalized EEG Suppression State.
cTnI, BNP and CRP profiling after seizures in patients with drug-resistant epilepsy.
Cyclooxygenase-2 expression and effect of celecoxib in flurothyl-induced neonatal seizure.
Equivocal significance of post-ictal generalized EEG suppression as a marker of SUDEP risk.
Excitation and Inhibition Balance Underlying Epileptiform Activity.
Ictal quantitative surface electromyography correlates with postictal EEG suppression.
Interictal 18F-FDG brain PET metabolism in patients with postictal EEG suppression.
Nocturnal seizures are associated with more severe hypoxemia and increased risk of postictal generalized EEG suppression.
Peri-ictal heart rate variability parameters as surrogate markers of seizure severity.
Periictal electroclinical characteristics of postictal generalized electroencephalographic suppression after generalized convulsive seizures.
Post-ictal Generalized EEG Suppression is reduced by Enhancing Dorsal Raphe Serotonergic Neurotransmission.
Postictal electroencephalographic (EEG) suppression: A stereo-EEG study of 100 focal to bilateral tonic-clonic seizures.
Postictal generalized EEG suppression after generalized convulsive seizures: A double-edged sword.
Postictal generalized EEG suppression and respiratory dysfunction following generalized tonic-clonic seizures in sleep and wakefulness.
Postictal generalized EEG suppression is linked to seizure-associated respiratory dysfunction but not postictal apnea.
Postictal generalized EEG suppression is not associated with periictal cardiac autonomic instability in people with convulsive seizures.
Postictal generalized electroencephalographic suppression following electroconvulsive therapy: Temporal characteristics and impact of anesthetic regimen.
Postictal generalized electroencephalographic suppression is associated with generalized seizures.
Postictal immobility and generalized EEG suppression are associated with the severity of respiratory dysfunction.
Postictal stertor: Associations with focal and bilateral seizure types.
Prevention of sudden unexpected death in epilepsy: current status and future perspectives.
Risk factors of postictal generalized EEG suppression in generalized convulsive seizures.
Seizure Clusters, Seizure Severity Markers, and SUDEP Risk.
The association of serotonin reuptake inhibitors and benzodiazepines with ictal central apnea.
The SUDEP Risk Inventory: Association with postictal generalized EEG suppression.
Tonic electromyographic activity following bilateral tonic-clonic seizures is associated with periictal respiratory dysfunction and postictal generalized EEG suppression.
Tonic phase of a generalized convulsive seizure is an independent predictor of postictal generalized EEG suppression.
Two predictors of postictal generalized EEG suppression: Tonic phase duration and postictal immobility period.
Voltage-based automated detection of postictal generalized electroencephalographic suppression: Algorithm development and validation.
Sepsis
Core temperature correlates with expression of selected stress and immunomodulatory genes in febrile patients with sepsis and noninfectious SIRS.
Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice.
Silicosis
Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis.
Sinusitis
Role of prostaglandin D2 and E2 terminal synthases in chronic rhinosinusitis.
Skin Neoplasms
Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis.
The cyclooxygenase-2-mediated prostaglandin signaling is causally related to epithelial carcinogenesis.
The expression pattern of prostaglandin E synthase and EP receptor isoforms in normal mouse skin and preinvasive skin neoplasms.
Sleep Apnea, Central
Prevention of sudden unexpected death in epilepsy: current status and future perspectives.
Seizure Clusters, Seizure Severity Markers, and SUDEP Risk.
Small Cell Lung Carcinoma
Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases.
Squamous Cell Carcinoma of Head and Neck
Expression of cyclooxygenase-2 and microsomal prostagalandin E synthase-1 in head and neck squamous cell carcinoma.
Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2.
Intersecting Mechanisms of Hypoxia and Prostaglandin E2-Mediated Inflammation in the Comparative Biology of Oral Squamous Cell Carcinoma.
Microsomal prostaglandin E synthase-1 is overexpressed in head and neck squamous cell carcinoma.
Prostaglandin E(2) pathway in head and neck squamous cell carcinoma.
Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx.
Stomach Neoplasms
Clinical significance of prostaglandin E synthase expression in gastric cancer tissue.
Expression of COX-2, mPGE-synthase1, MDR-1 (P-gp), and Bcl-xL: a molecular pathway of H pylori-related gastric carcinogenesis.
Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines.
Expression of proteins related to prostaglandin E2 biosynthesis is increased in human gastric cancer and during gastric carcinogenesis.
Gastric adenomas: relationship between clinicopathological findings, Helicobacter pylori infection, APC mutations and COX-2 expression.
Stomach Ulcer
Microsomal prostaglandin E synthase (mPGES)-1, mPGES-2 and cytosolic PGES expression in human gastritis and gastric ulcer tissue.
Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers.
The role of cyclooxygenase in gastric mucosal protection.
Stroke
Interactions among Variants in Eicosanoid Genes Increase Risk of Atherothrombotic Stroke in Chinese Populations.
Membrane prostaglandin E synthase-1: a novel therapeutic target.
Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity.
Microsomal prostaglandin E synthase-1 contributes to ischaemic excitotoxicity through prostaglandin E2 EP3 receptors.
Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury.
Molecular docking and competitive binding study discovered different binding modes of microsomal prostaglandin E synthase-1 inhibitors.
The role of prostaglandin e2 in stroke-reperfusion injury.
Stupor
Ecotoxicological characterization of polyoxyethylene glycerol ester non-ionic surfactants and their mixtures with anionic and non-ionic surfactants.
Subarachnoid Hemorrhage
Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin.
Sudden Unexpected Death in Epilepsy
Age-specific periictal electroclinical features of generalized tonic-clonic seizures and potential risk of sudden unexpected death in epilepsy (SUDEP).
An electroclinical case-control study of sudden unexpected death in epilepsy.
Automated Analysis of Risk Factors for Postictal Generalized EEG Suppression.
Automated detection of activity onset after postictal generalized EEG suppression.
Automated Detection of Postictal Generalized EEG Suppression.
Automated Video Detection of Epileptic Convulsion Slowing as a Precursor for Post-Seizure Neuronal Collapse.
Autonomic changes following generalized tonic clonic seizures: An analysis of adult and pediatric patients with epilepsy.
Autonomic dysregulation in children with epilepsy with postictal generalized EEG suppression following generalized convulsive seizures.
Categorisation of EEG suppression using enhanced feature extraction for SUDEP risk assessment.
Characteristics of postictal generalized EEG suppression in children.
Cortical thinning in epilepsy patients with postictal generalized electroencephalography suppression.
Detection of Postictal Generalized Electroencephalogram Suppression: Random Forest Approach.
Equivocal significance of post-ictal generalized EEG suppression as a marker of SUDEP risk.
Impact of periictal nurse interventions on postictal generalized EEG suppression in generalized convulsive seizures.
Near SUDEP during bilateral stereo-EEG monitoring characterized by diffuse postictal EEG suppression.
Nocturnal seizures are associated with more severe hypoxemia and increased risk of postictal generalized EEG suppression.
Periictal autonomic dysfunction and generalized postictal EEG suppression in convulsive seizures arising from sleep and wakefulness.
Periictal electroclinical characteristics of postictal generalized electroencephalographic suppression after generalized convulsive seizures.
Postictal generalized EEG suppression and respiratory dysfunction following generalized tonic-clonic seizures in sleep and wakefulness.
Postictal generalized EEG suppression is linked to seizure-associated respiratory dysfunction but not postictal apnea.
Postictal generalized EEG suppression is not associated with periictal cardiac autonomic instability in people with convulsive seizures.
Postictal generalized electroencephalographic suppression is associated with generalized seizures.
Prevention of sudden unexpected death in epilepsy: current status and future perspectives.
Significant postictal hypotension: Expanding the spectrum of seizure-induced autonomic dysregulation.
Tonic electromyographic activity following bilateral tonic-clonic seizures is associated with periictal respiratory dysfunction and postictal generalized EEG suppression.
Tonic phase of a generalized convulsive seizure is an independent predictor of postictal generalized EEG suppression.
Two predictors of postictal generalized EEG suppression: Tonic phase duration and postictal immobility period.
Syncope, Vasovagal
Significant postictal hypotension: Expanding the spectrum of seizure-induced autonomic dysregulation.
Tachycardia
Characteristics of postictal generalized EEG suppression in children.
Teratoma
Characterization and multilineage differentiation of embryonic stem cells derived from a buffalo parthenogenetic embryo.
Thrombosis
An Update of Microsomal Prostaglandin E Synthase-1 and PGE2 Receptors in Cardiovascular Health and Diseases.
Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury.
Production of prostaglandin E2 induced by cigarette smoke modulates tissue factor expression and activity in endothelial cells.
Thyroid Cancer, Papillary
Immunohistochemical Demonstration of Membrane-bound Prostaglandin E(2) Synthase-1 in Papillary Thyroid Carcinoma.
Thyroid Neoplasms
Immunohistochemical Demonstration of Membrane-bound Prostaglandin E(2) Synthase-1 in Papillary Thyroid Carcinoma.
Triple Negative Breast Neoplasms
Kruppel-like Factor 5 Transcription Factor Promotes Microsomal Prostaglandin E2 Synthase 1 Gene Transcription in Breast Cancer.
Ureteral Obstruction
Deficiency of mPGES-1 exacerbates renal fibrosis and inflammation in mice with unilateral ureteral obstruction.
Uterine Cervical Neoplasms
COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells.
Vascular Diseases
Microsomal Prostaglandin E2 Synthase-1 Deletion Attenuates Isoproterenol-Induced Myocardial Fibrosis in Mice.
The role of prostaglandin E2 in human vascular inflammation.
Vascular System Injuries
Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1.
Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury.
Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice.
Venous Thrombosis
Prostaglandin E synthase is upregulated by Gas6 during cancer-induced venous thrombosis.
Virus Diseases
C. albicans activates cyclooxygenase but not its product prostaglandin E? in HPV 16-stabilized cells.
Transcriptomic Analysis of the Innate Antiviral Immune Response in Porcine Intestinal Epithelial Cells: Influence of Immunobiotic Lactobacilli.