Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.3.99.3 extracted from

  • Shang, E.; Wu, Y.; Liu, P.; Liu, Y.; Zhu, W.; Deng, X.; He, C.; He, S.; Li, C.; Lai, L.
    Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 (2014), Bioorg. Med. Chem. Lett., 24, 2764-2767.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-(naphthalen-1-ylamino)-6-nitrobenzo[d]isothiazole 1,1-dioxide
-
Homo sapiens
6-nitro-3-(m-tolylamino) benzo[d]isothiazole 1,1-dioxide i.e. JMC-7 Homo sapiens
6-nitro-N-phenyl-1,2-benzothiazol-3-amine 1,1-dioxide
-
Homo sapiens
6-nitro-N-[3-(propan-2-yl)phenyl]-1,2-benzothiazol-3-amine 1,1-dioxide
-
Homo sapiens
MF63
-
Homo sapiens
additional information synthesis and inhibitory potency of a series of 6-nitro-3-(m-tolylamino) benzo[d]isothiazole 1,1-dioxide analogues against microsomal prostaglandin E2 synthase. No inhibition by Zileuton Homo sapiens
N-(1,3-benzodioxol-4-yl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
-
Homo sapiens
N-(2-methylphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
-
Homo sapiens
N-(3,4-dimethoxyphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
-
Homo sapiens
N-(3-bromobenzyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
-
Homo sapiens
N-(3-bromophenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
-
Homo sapiens
N-(3-chlorophenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
-
Homo sapiens
N-(3-methoxyphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
-
Homo sapiens
N-(3-tert-butylphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
-
Homo sapiens
N-(4-methoxyphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
-
Homo sapiens
N-(5-bromonaphthalen-1-yl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
-
Homo sapiens
N-(6-nitro-1,1-dioxido-1,2-benzothiazol-3-yl)quinolin-5-amine
-
Homo sapiens
N-(biphenyl-3-yl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome isozyme mPGES-1 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
microsomal isozyme mPGES-1
-

Synonyms

Synonyms Comment Organism
microsomal prostaglandin E2 synthase-1
-
Homo sapiens
mPGES-1
-
Homo sapiens
prostaglandin E2 synthase-1
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000003
-
pH and temperature not specified in the publication Homo sapiens MF63
0.00015
-
0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens N-(6-nitro-1,1-dioxido-1,2-benzothiazol-3-yl)quinolin-5-amine
0.0021
-
0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens 3-(naphthalen-1-ylamino)-6-nitrobenzo[d]isothiazole 1,1-dioxide
0.0057
-
0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens N-(3-chlorophenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
0.0067
-
0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens 6-nitro-3-(m-tolylamino) benzo[d]isothiazole 1,1-dioxide
0.0073
-
0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens N-(3-bromophenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
0.0088
-
0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens N-(3-methoxyphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
0.0169
-
0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens N-(4-methoxyphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
0.0236
-
0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens 6-nitro-N-phenyl-1,2-benzothiazol-3-amine 1,1-dioxide
0.05
-
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens N-(2-methylphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
0.05
-
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens 6-nitro-N-[3-(propan-2-yl)phenyl]-1,2-benzothiazol-3-amine 1,1-dioxide
0.05
-
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens N-(3-tert-butylphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
0.05
-
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens N-(biphenyl-3-yl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
0.05
-
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens N-(5-bromonaphthalen-1-yl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
0.05
-
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens N-(1,3-benzodioxol-4-yl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
0.05
-
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°C Homo sapiens N-(3,4-dimethoxyphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide
0.05
-
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°Cn Homo sapiens N-(3-bromobenzyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide