Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(naphthalen-1-ylamino)-6-nitrobenzo[d]isothiazole 1,1-dioxide | - |
Homo sapiens | |
6-nitro-3-(m-tolylamino) benzo[d]isothiazole 1,1-dioxide | i.e. JMC-7 | Homo sapiens | |
6-nitro-N-phenyl-1,2-benzothiazol-3-amine 1,1-dioxide | - |
Homo sapiens | |
6-nitro-N-[3-(propan-2-yl)phenyl]-1,2-benzothiazol-3-amine 1,1-dioxide | - |
Homo sapiens | |
MF63 | - |
Homo sapiens | |
additional information | synthesis and inhibitory potency of a series of 6-nitro-3-(m-tolylamino) benzo[d]isothiazole 1,1-dioxide analogues against microsomal prostaglandin E2 synthase. No inhibition by Zileuton | Homo sapiens | |
N-(1,3-benzodioxol-4-yl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | - |
Homo sapiens | |
N-(2-methylphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | - |
Homo sapiens | |
N-(3,4-dimethoxyphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | - |
Homo sapiens | |
N-(3-bromobenzyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | - |
Homo sapiens | |
N-(3-bromophenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | - |
Homo sapiens | |
N-(3-chlorophenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | - |
Homo sapiens | |
N-(3-methoxyphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | - |
Homo sapiens | |
N-(3-tert-butylphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | - |
Homo sapiens | |
N-(4-methoxyphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | - |
Homo sapiens | |
N-(5-bromonaphthalen-1-yl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | - |
Homo sapiens | |
N-(6-nitro-1,1-dioxido-1,2-benzothiazol-3-yl)quinolin-5-amine | - |
Homo sapiens | |
N-(biphenyl-3-yl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | isozyme mPGES-1 | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
microsomal isozyme mPGES-1 | - |
Synonyms | Comment | Organism |
---|---|---|
microsomal prostaglandin E2 synthase-1 | - |
Homo sapiens |
mPGES-1 | - |
Homo sapiens |
prostaglandin E2 synthase-1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000003 | - |
pH and temperature not specified in the publication | Homo sapiens | MF63 | |
0.00015 | - |
0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | N-(6-nitro-1,1-dioxido-1,2-benzothiazol-3-yl)quinolin-5-amine | |
0.0021 | - |
0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | 3-(naphthalen-1-ylamino)-6-nitrobenzo[d]isothiazole 1,1-dioxide | |
0.0057 | - |
0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | N-(3-chlorophenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | |
0.0067 | - |
0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | 6-nitro-3-(m-tolylamino) benzo[d]isothiazole 1,1-dioxide | |
0.0073 | - |
0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | N-(3-bromophenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | |
0.0088 | - |
0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | N-(3-methoxyphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | |
0.0169 | - |
0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | N-(4-methoxyphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | |
0.0236 | - |
0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | 6-nitro-N-phenyl-1,2-benzothiazol-3-amine 1,1-dioxide | |
0.05 | - |
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | N-(2-methylphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | |
0.05 | - |
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | 6-nitro-N-[3-(propan-2-yl)phenyl]-1,2-benzothiazol-3-amine 1,1-dioxide | |
0.05 | - |
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | N-(3-tert-butylphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | |
0.05 | - |
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | N-(biphenyl-3-yl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | |
0.05 | - |
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | N-(5-bromonaphthalen-1-yl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | |
0.05 | - |
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | N-(1,3-benzodioxol-4-yl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | |
0.05 | - |
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°C | Homo sapiens | N-(3,4-dimethoxyphenyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide | |
0.05 | - |
above, 0.1 M potassium phosphate buffer, pH 7.4, 4°Cn | Homo sapiens | N-(3-bromobenzyl)-6-nitro-1,2-benzothiazol-3-amine 1,1-dioxide |