Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[2-(2-methylphenyl)ethyl]-4-[2'-[(naphthalen-1-yloxy)methyl]biphenyl-4-yl]-1H-1,2,3-triazole | 90% residual activity at 0.03 mM | Homo sapiens | |
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid | 12% residual activity at 0.03 mM | Homo sapiens | |
4'-[1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl]biphenyl-4-ol | 73.6% residual activity at 0.03 mM | Homo sapiens | |
4'-[1-[(phenylsulfanyl)methyl]-1H-1,2,3-triazol-4-yl]biphenyl-3-ol | 60.1% residual activity at 0.03 mM | Homo sapiens | |
4'-[1-[(phenylsulfanyl)methyl]-1H-1,2,3-triazol-4-yl]biphenyl-4-ol | 89% residual activity at 0.03 mM | Homo sapiens | |
4'-[1-[2-(2-methylphenyl)ethyl]-1H-1,2,3-triazol-4-yl]biphenyl-4-amine | 98.2% residual activity at 0.03 mM | Homo sapiens | |
4-(2'-[[2-chloro-5-(trifluoromethyl)phenoxy]methyl]biphenyl-4-yl)-1-(3-phenylpropyl)-1H-1,2,3-triazole | 91.9% residual activity at 0.03 mM | Homo sapiens | |
4-(2'-[[2-chloro-5-(trifluoromethyl)phenoxy]methyl]biphenyl-4-yl)-1-[2-(2-methylphenyl)ethyl]-1H-1,2,3-triazole | 87.9% residual activity at 0.03 mM | Homo sapiens | |
4-(4'-phenoxybiphenyl-4-yl)-1-(3-phenylpropyl)-1H-1,2,3-triazole | 88.7% residual activity at 0.03 mM | Homo sapiens | |
4-[(4-[2'-[(naphthalen-1-yloxy)methyl]biphenyl-4-yl]-1H-1,2,3-triazol-1-yl)sulfonyl]benzoic acid | 59.8% residual activity at 0.03 mM | Homo sapiens | |
4-[2'-[(naphthalen-1-yloxy)methyl]biphenyl-4-yl]-1-(3-phenylpropyl)-1H-1,2,3-triazole | 96.8% residual activity at 0.03 mM | Homo sapiens | |
4-[4-(phenanthren-9-yl)phenyl]-1-(3-phenylpropyl)-1H-1,2,3-triazole | 78.2% residual activity at 0.03 mM | Homo sapiens | |
4-[4-benzyl-1-[(phenylsulfanyl)methyl]-1H-1,2,3-triazol-5-yl]benzaldehyde | 72.1% residual activity at 0.03 mM | Homo sapiens | |
4-[[4-(biphenyl-4-yl)-1H-1,2,3-triazol-1-yl]methyl]-3-nitrobenzoic acid | most efficient inhibitor of mPGES-1, 12% residual activity at 0.03 mM | Homo sapiens | |
5-(dimethylamino)-N-[4'-[1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl]biphenyl-4-yl]naphthalene-1-sulfonamide | 85% residual activity at 0.03 mM | Homo sapiens | |
[1-[(phenylsulfanyl)methyl]-1H-1,2,3-triazol-4-yl]methyl benzoate | 76.1% residual activity at 0.03 mM | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | Homo sapiens | - |
Prostaglandin E2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Homo sapiens | Prostaglandin E2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
microsomal prostaglandin E synthase-1 | - |
Homo sapiens |
mPGES-1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0024 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid | |
0.0032 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[[4-(biphenyl-4-yl)-1H-1,2,3-triazol-1-yl]methyl]-3-nitrobenzoic acid | |
0.03 | - |
IC50 above 0.03 mM, pH and temperature not specified in the publication | Homo sapiens | 4'-[1-[(phenylsulfanyl)methyl]-1H-1,2,3-triazol-4-yl]biphenyl-4-ol | |
0.03 | - |
IC50 above 0.03 mM, pH and temperature not specified in the publication | Homo sapiens | 4'-[1-[(phenylsulfanyl)methyl]-1H-1,2,3-triazol-4-yl]biphenyl-3-ol | |
0.03 | - |
IC50 above 0.03 mM, pH and temperature not specified in the publication | Homo sapiens | 4-[4-(phenanthren-9-yl)phenyl]-1-(3-phenylpropyl)-1H-1,2,3-triazole | |
0.03 | - |
IC50 above 0.03 mM, pH and temperature not specified in the publication | Homo sapiens | [1-[(phenylsulfanyl)methyl]-1H-1,2,3-triazol-4-yl]methyl benzoate | |
0.03 | - |
IC50 above 0.03 mM, pH and temperature not specified in the publication | Homo sapiens | 4'-[1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl]biphenyl-4-ol | |
0.03 | - |
IC50 above 0.03 mM, pH and temperature not specified in the publication | Homo sapiens | 4-[2'-[(naphthalen-1-yloxy)methyl]biphenyl-4-yl]-1-(3-phenylpropyl)-1H-1,2,3-triazole | |
0.03 | - |
IC50 above 0.03 mM, pH and temperature not specified in the publication | Homo sapiens | 4-(2'-[[2-chloro-5-(trifluoromethyl)phenoxy]methyl]biphenyl-4-yl)-1-(3-phenylpropyl)-1H-1,2,3-triazole | |
0.03 | - |
IC50 above 0.03 mM, pH and temperature not specified in the publication | Homo sapiens | 4-(2'-[[2-chloro-5-(trifluoromethyl)phenoxy]methyl]biphenyl-4-yl)-1-[2-(2-methylphenyl)ethyl]-1H-1,2,3-triazole | |
0.03 | - |
IC50 above 0.03 mM, pH and temperature not specified in the publication | Homo sapiens | 4-[(4-[2'-[(naphthalen-1-yloxy)methyl]biphenyl-4-yl]-1H-1,2,3-triazol-1-yl)sulfonyl]benzoic acid | |
0.03 | - |
IC50 above 0.03 mM, pH and temperature not specified in the publication | Homo sapiens | 5-(dimethylamino)-N-[4'-[1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl]biphenyl-4-yl]naphthalene-1-sulfonamide | |
0.03 | - |
IC50 above 0.03 mM, pH and temperature not specified in the publication | Homo sapiens | 1-[2-(2-methylphenyl)ethyl]-4-[2'-[(naphthalen-1-yloxy)methyl]biphenyl-4-yl]-1H-1,2,3-triazole | |
0.03 | - |
IC50 above 0.03 mM, pH and temperature not specified in the publication | Homo sapiens | 4-[4-benzyl-1-[(phenylsulfanyl)methyl]-1H-1,2,3-triazol-5-yl]benzaldehyde | |
0.03 | - |
IC50 above 0.03 mM, pH and temperature not specified in the publication | Homo sapiens | 4'-[1-[2-(2-methylphenyl)ethyl]-1H-1,2,3-triazol-4-yl]biphenyl-4-amine | |
0.03 | - |
IC50 above 0.03 mM, pH and temperature not specified in the publication | Homo sapiens | 4-(4'-phenoxybiphenyl-4-yl)-1-(3-phenylpropyl)-1H-1,2,3-triazole |