Literature summary for 5.3.99.3 extracted from

Inada, M.; Matsumoto, C.; Uematsu, S.; Akira, S.; Miyaura, C.
Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation (2006), J. Immunol., 177, 1879-1885.

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Activating Compound

Activating Compound	Comment	Organism	Structure
lipopolysaccharide	lipopolysaccharide binds to receptor TLR4 on osteoblasts that directly induces isoform mPGES-1 expression for prostaglandin E2 synthesis, leading to subsequent bone resorption	Mus musculus

Application

Application	Comment	Organism
medicine	use of isoform mPGES-1 as a target for the treatment of inflammatory bone disease	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	isoform mPGES-1 knockout mice. Contrary to wild-type, in knock-out animals no prostaglandin E2 production is found in osteoblast after administration of LPS. While in wild-type, LPS reduces the bone volume in femur associated with an increased number of osteoclasts, this loss is reduced in knock-out mice. LPS induces the loss of alveolar bone in wild-type, but not in the mutants	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isoform mPGES-1	-

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Release 2023.1 (January 2023)