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Literature summary for 5.3.99.3 extracted from

  • Jia, Z.; Guo, X.; Zhang, H.; Wang, M.H.; Dong, Z.; Yang, T.
    Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress (2008), Hypertension, 52, 952-959.
    View publication on PubMed
Search for more literature for 5.3.99.3

Activating Compound

Activating Compound Comment Organism Structure
angiotensin II angiotension II infusion induces mRNA expression of mPGES-1, mPGES-2 and cytosolic PGE synthase Mus musculus

Application

Application Comment Organism
medicine mPGES-1 is a potential target of anti-inflammatory drugs Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-
microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Mus musculus
-
 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Mus musculus (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Synonyms

Synonyms Comment Organism
microsomal PG synthase-1
-
 Mus musculus
microsomal prostaglandin synthase-1
-
 Mus musculus
mPGES-1
-
 Mus musculus
prostaglandin synthase-1
-
 Mus musculus
prostaglandin-E synthase
-
 Mus musculus