Reference on EC 3.4.21.79 - granzyme B
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Odake, S.; Kam, C.M.; Narasimhan, L.; Poe, M.; Blake, J.T.; Krahenbuhl, O.; Tschopp, J.; Powers, J.C.
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins
Biochemistry
30
2217-2227
1991
Homo sapiens, Mus musculus
Schmid, J.; Weissmann, C.
Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes
J. Immunol.
139
250-259
1987
Homo sapiens
Poe, M.; Blake, J.T.; Boulton, D.A.; Gammon, M.; Sigal, N.H.; Wu, J.K.; Zweerink, H.J.
Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity
J. Biol. Chem.
266
98-103
1991
Homo sapiens
Peitsch, M.C.; Tschopp, J.
Granzyme B
Methods Enzymol.
244
80-87
1994
Homo sapiens, Mus musculus
Trapani, J.A.; Browne, K.A.; Dawson, M.; Smyth, M.J.
Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody
Biochem. Biophys. Res. Commun.
195
910-920
1993
Homo sapiens
Darmon, A.J.; Nicholson, D.W.; Bleackley, C.
Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
Nature
377
446-448
1995
Homo sapiens
Smyth, M.J.; McGuire, M.J.; Thia, K.Y.T.
Expression of recombinant human granzyme B. A processing and activation role for dipeptidyl peptidase I
J. Immunol.
154
6299-6305
1995
Homo sapiens
Gu, Y.; Sarnecki, C.; Fleming, M.A.; Lippke, J.A.; Bleackley, R.C.; Su, M.S.S.
Processing and activation of CMH-1 by granzyme B
J. Biol. Chem.
271
10816-10820
1996
Homo sapiens
Quan, L.T.; Tewari, M.; O'Rourke, K.; Dixit, V.; Snipas, S.J.; Poirier, G.G.; Ray, C.; Pickup, D.J.; Salvesen, G.S.
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B
Proc. Natl. Acad. Sci. USA
93
1972-1976
1996
Homo sapiens
Caputo, A.; James, M.N.G.; Powers, J.C.; Hudig, D.; Bleackley, R.C.
Conversion of the substrate specificity of mouse proteinase granzyme B
Nat. Struct. Biol.
1
364-367
1994
Mus musculus
Xia, Z.; Kam, C.M.; Huang, C.; Powers, J.C.; Mandle, R.J.; Stevens, R.L.; Lieberman, J.
Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system
Biochem. Biophys. Res. Commun.
243
384-389
1998
Homo sapiens, Mus musculus
Sun, J.; Bird, C.H.; Buzza, M.S.; McKee, K.E.; Whisstock, J.C.; Bird, P.I.
Expression and purification of recombinant human granzyme B from Pichia pastoris
Biochem. Biophys. Res. Commun.
261
251-255
1999
Homo sapiens
Estebanez-Perpina, E.; Fuentes-Prior, P.; Belorgey, D.; Braun, M.; Kiefersauer, R.; Maskos, K.; Huber, R.; Rubin, H.; Bode, W.
Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue
Biol. Chem.
381
1203-1214
2000
Homo sapiens
Rotonda, J.; Garcia-Calvo, M.; Bull, H.G.; Geissler, W.M.; McKeever, B.M.; Willoughby, C.A.; Thornberry, N.A.; Becker, J.W.
The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1
Chem. Biol.
8
357-368
2001
Homo sapiens
Van de Craen, M.; Van den Brande, I.; Declercq, W.; Irmler, M.; Beyaert, R.; Tschopp, J.; Fiers, W.; Vandenabeele, P.
Cleavage of caspase family members by granzyme B. A comparative study in vitro
Eur. J. Immunol.
27
1296-1299
1997
Mus musculus
Andrade, F.; Roy, S.; Nicholson, D.; Thornberry, N.; Rosen, A.; Casciola-Rosen, L.
Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis
Immunity
8
451-460
1998
Homo sapiens
Kanamori, H.; Krieg, S.; Mao, C.; Di Pippo, V.A.; Wang, S.; Zajchowski, D.A.; Shapiro, D.J.
Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells
J. Biol. Chem.
275
5867-5873
2000
Homo sapiens
Sun, J.; Whisstock, J.C.; Harriott, P.; Walker, B.; Novak, A.; Thompson, P.E.; Smith, A.I.; Bird, P.I.
Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop
J. Biol. Chem.
276
15177-15184
2001
Homo sapiens
Shi, L.; Yang, X.; Froelich, C.J.; Greenberg, A.H.
Purification and use of granzyme B
Methods Enzymol.
322
125-143
2000
Homo sapiens, Mus musculus, Rattus norvegicus
Andrade, F.; Casciola-Rosen, L.A.; Rosen, A.
A novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: possible interaction with a species-specific exosite
Mol. Cell. Biol.
23
6315-6326
2003
Homo sapiens, Mus musculus, Rattus norvegicus
Waugh, S.M.; Harris, J.L.; Fletterick, R.; Craik, C.S.
The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity
Nat. Struct. Biol.
7
762-765
2000
Rattus norvegicus
Giesuebel, U.; Daelken, B.; Mahmud, H.; Wels, W.S.
Cell binding, internalization and cytotoxic activity of human granzyme B expressed in the yeast Pichia pastoris
Biochem. J.
394
563-573
2006
Homo sapiens
Grossman, W.J.; Verbsky, J.W.; Tollefsen, B.L.; Kemper, C.; Atkinson, J.P.; Ley, T.J.
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells
Blood
104
2840-2848
2004
Homo sapiens
Mahrus, S.; Craik, C.S.
Selective chemical functional probes of granzymes A and B reveal granzyme B Is a major effector of natural killer cell-mediated lysis of target cells
Chem. Biol.
12
567-577
2005
Homo sapiens
Sun, J.; Bird, C.H.; Thia, K.Y.; Matthews, A.Y.; Trapani, J.A.; Bird, P.I.
Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity
J. Biol. Chem.
279
16907-16911
2004
Homo sapiens
Ruggles, S.W.; Fletterick, R.J.; Craik, C.S.
Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity
J. Biol. Chem.
279
30751-30759
2004
Rattus norvegicus (P18291)
Loeb, C.R.; Harris, J.L.; Craik, C.S.
Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance towards apoptosis
J. Biol. Chem.
281
28326-28335
2006
Homo sapiens
Pardo, J.; Bosque, A.; Brehm, R.; Wallich, R.; Naval, J.; Mullbacher, A.; Anel, A.; Simon, M.M.
Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis
J. Cell Biol.
167
457-468
2004
Mus musculus
Blink, E.J.; Jiansheng, Z.; Hu, W.; Calanni, S.T.; Trapani, J.A.; Bird, P.I.; Jans, D.A.
Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9
J. Cell. Biochem.
95
598-610
2005
Homo sapiens
Lorentsen, R.H.; Fynbo, C.H.; Thogersen, H.C.; Etzerodt, M.; Holtet, T.L.
Expression, refolding, and purification of recombinant human granzyme B
Protein Expr. Purif.
39
18-26
2005
Homo sapiens
Kuerten, S.; Nowacki, T.M.; Kleen, T.O.; Asaad, R.J.; Lehmann, P.V.; Tary-Lehmann, M.
Dissociated production of perforin, granzyme B, and IFN-gamma by HIV-specific CD8(+) cells in HIV infection
AIDS Res. Hum. Retroviruses
24
62-71
2008
Homo sapiens
Duggan, B.L.; Cabilio, N.R.; Dickie, P.; Witmer, J.; Goping, I.S.; Underhill, D.A.; Bleackley, R.C.
A novel lineage-specific hypersensitive site is essential for position independent granzyme B expression in transgenic mice
Biochem. Biophys. Res. Commun.
368
357-363
2008
Mus musculus
Fellows, E.; Gil-Parrado, S.; Jenne, D.E.; Kurschus, F.C.
Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program
Blood
110
544-552
2007
Homo sapiens
Chamberlain, C.M.; Granville, D.J.
The role of Granzyme B in atheromatous diseases
Can. J. Physiol. Pharmacol.
85
89-95
2007
Homo sapiens, Mus musculus
Pardo, J.; Wallich, R.; Ebnet, K.; Iden, S.; Zentgraf, H.; Martin, P.; Ekiciler, A.; Prins, A.; Muellbacher, A.; Huber, M.; Simon, M.M.
Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin
Cell Death Differ.
14
1768-1779
2007
Mus musculus
Pardo, J.; Wallich, R.; Martin, P.; Urban, C.; Rongvaux, A.; Flavell, R.A.; Muellbacher, A.; Borner, C.; Simon, M.M.
Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs
Cell Death Differ.
15
567-579
2008
Mus musculus
Nowacki, T.M.; Kuerten, S.; Zhang, W.; Shive, C.L.; Kreher, C.R.; Boehm, B.O.; Lehmann, P.V.; Tary-Lehmann, M.
Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells
Cell. Immunol.
247
36-48
2007
Homo sapiens
Andrade, F.; Fellows, E.; Jenne, D.E.; Rosen, A.; Young, C.S.
Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition
EMBO J.
26
2148-2157
2007
Homo sapiens
Cao, X.; Cai, S.F.; Fehniger, T.A.; Song, J.; Collins, L.I.; Piwnica-Worms, D.R.; Ley, T.J.
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance
Immunity
27
635-646
2007
Mus musculus, Mus musculus 129/SvJ
Bredemeyer, A.J.; Carrigan, P.E.; Fehniger, T.A.; Smith, D.F.; Ley, T.J.
Hop cleavage and function in granzyme B-induced apoptosis
J. Biol. Chem.
281
37130-37141
2006
Homo sapiens, Mus musculus
Hostetter, D.R.; Loeb, C.R.; Chu, F.; Craik, C.S.
Hip is a pro-survival substrate of granzyme B
J. Biol. Chem.
282
27865-27874
2007
Homo sapiens
Meslin, F.; Thiery, J.; Richon, C.; Jalil, A.; Chouaib, S.
Granzyme B-induced cell death involves induction of p53 tumor suppressor gene and its activation in tumor target cells
J. Biol. Chem.
282
32991-32999
2007
Homo sapiens
Casciola-Rosen, L.; Garcia-Calvo, M.; Bull, H.G.; Becker, J.W.; Hines, T.; Thornberry, N.A.; Rosen, A.
Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway
J. Biol. Chem.
282
4545-4552
2007
Homo sapiens, Mus musculus
Cullen, S.P.; Adrain, C.; Luethi, A.U.; Duriez, P.J.; Martin, S.J.
Human and murine granzyme B exhibit divergent substrate preferences
J. Cell Biol.
176
435-444
2007
Homo sapiens, Mus musculus
Goping, I.S.; Sawchuk, T.; Underhill, D.A.; Bleackley, R.C.
Identification of alpha-tubulin as a granzyme B substrate during CTL-mediated apoptosis
J. Cell Sci.
119
858-865
2006
Homo sapiens
Ammar, M.; Mokni, M.; Boubaker, S.; El Goaied, A.; Ben Osman, A.; Louzir, H.
Involvement of granzyme B and granulysin in the cytotoxic response in lichen planus
J. Cutan. Pathol.
35
630-634
2008
Homo sapiens
Packard, B.Z.; Telford, W.G.; Komoriya, A.; Henkart, P.A.
Granzyme B activity in target cells detects attack by cytotoxic lymphocytes
J. Immunol.
179
3812-3820
2007
Homo sapiens
Batinac, T.; Zamolo, G.; Coklo, M.; Hadzisejdic, I.
Possible key role of granzyme B in keratoacanthoma regression
Med. Hypotheses
66
1129-1132
2006
Homo sapiens
Strik, M.C.; de Koning, P.J.; Kleijmeer, M.J.; Bladergroen, B.A.; Wolbink, A.M.; Griffith, J.M.; Wouters, D.; Fukuoka, Y.; Schwartz, L.B.; Hack, C.E.; van Ham, S.M.; Kummer, J.A.
Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation
Mol. Immunol.
44
3462-3472
2007
Homo sapiens
Hou, Q.; Zhao, T.; Zhang, H.; Lu, H.; Zhang, Q.; Sun, L.; Fan, Z.
Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage
Mol. Immunol.
45
1044-1055
2008
Homo sapiens
Morissette, M.C.; Parent, J.; Milot, J.
Perforin, granzyme B, and FasL expression by peripheral blood T lymphocytes in emphysema
Respir. Res.
8
62
2007
Homo sapiens
Sutton, V.R.; Estella, E.; Li, C.; Chen, M.; Thomas, H.E.; Kay, T.W.; Trapani, J.A.
A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death
Transplantation
81
146-154
2006
Mus musculus
Waterhouse, N.J.; Trapani, J.A.
H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells
Trends Immunol.
28
373-375
2007
Homo sapiens, Mus musculus
Piuko, K.; Bravo, I.G.; Mueller, M.
Identification and characterization of equine granzyme B
Vet. Immunol. Immunopathol.
118
239-251
2007
Homo sapiens, Equus caballus (Q2A6L4), Equus caballus
Freishtat, R.J.; Natale, J.; Benton, A.S.; Cohen, J.; Sharron, M.; Wiles, A.A.; Ngor, W.M.; Mojgani, B.; Bradbury, M.; Degnan, A.; Sachdeva, R.; Debiase, L.M.; Ghimbovschi, S.; Chow, M.; Bunag, C.; Kristosturyan, E.; Hoffman, E.P.
Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity
Am. J. Respir. Crit. Care Med.
179
467-473
2009
Homo sapiens, Mus musculus
Besenicar, M.P.; Metkar, S.; Wang, B.; Froelich, C.J.; Anderluh, G.
Granzyme B translocates across the lipid membrane only in the presence of lytic agents
Biochem. Biophys. Res. Commun.
371
391-394
2008
Homo sapiens
Romero, V.; Fellows, E.; Jenne, D.E.; Andrade, F.
Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity
Cell Death Differ.
16
340-348
2009
Homo sapiens
Nishimura, M.; Sato, H.; Okazaki, H.; Satake, M.; Tadokoro, K.
Interleukin-10 containing normal human serum inhibits granzyme B release but not perforin release from alloreactive and EBV-specific T cell clones
Cell. Immunol.
251
31-36
2008
Homo sapiens
Kondo, H.; Hojo, Y.; Tsuru, R.; Nishimura, Y.; Shimizu, H.; Takahashi, N.; Hirose, M.; Ikemoto, T.; Ohya, K.; Katsuki, T.; Yashiro, T.; Shimada, K.
Elevation of plasma granzyme B levels after acute myocardial infarction
Circ. J.
73
503-507
2009
Homo sapiens
Takahashi, Y.; Mine, J.; Kubota, Y.; Yamazaki, E.; Fujiwara, T.
A substantial number of Rasmussen syndrome patients have increased IgG, CD4(+) T cells, TNFalpha, and granzyme B in CSF
Epilepsia
50
1419-1431
2009
Homo sapiens
Prakash, M.D.; Bird, C.H.; Bird, P.I.
Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement
Immunol. Cell Biol.
87
249-254
2009
Homo sapiens
Bratke, K.; Goettsching, H.; Kuepper, M.; Geyer, S.; Luttmann, W.; Virchow, J.C.
Interleukin-4 suppresses the cytotoxic potential of in vitro generated, adaptive regulatory CD4(+) T cells by down-regulation of granzyme B
Immunology
127
338-344
2008
Homo sapiens
Buzza, M.S.; Dyson, J.M.; Choi, H.; Gardiner, E.E.; Andrews, R.K.; Kaiserman, D.; Mitchell, C.A.; Berndt, M.C.; Dong, J.F.; Bird, P.I.
Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor
J. Biol. Chem.
283
22498-22504
2008
Homo sapiens
Araki, Y.; Fann, M.; Wersto, R.; Weng, N.P.
Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B)
J. Immunol.
180
8102-8108
2008
Homo sapiens
Chattopadhyay, P.K.; Betts, M.R.; Price, D.A.; Gostick, E.; Horton, H.; Roederer, M.; De Rosa, S.C.
The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression
J. Leukoc. Biol.
85
88-97
2009
Homo sapiens
Casciola-Rosen, L.; Miagkov, A.; Nagaraju, K.; Askin, F.; Jacobson, L.; Rosen, A.; Drachman, D.B.
Granzyme B: evidence for a role in the origin of myasthenia gravis
J. Neuroimmunol.
201-202
33-40
2008
Homo sapiens
Van Damme, P.; Maurer-Stroh, S.; Plasman, K.; Van Durme, J.; Colaert, N.; Timmerman, E.; De Bock, P.J.; Goethals, M.; Rousseau, F.; Schymkowitz, J.; Vandekerckhove, J.; Gevaert, K.
Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs
Mol. Cell. Proteomics
8
258-272
2009
Homo sapiens, Mus musculus
Jahrsdoerfer, B.; Vollmer, A.; Blackwell, S.E.; Maier, J.; Sontheimer, K.; Beyer, T.; Mandel, B.; Lunov, O.; Tron, K.; Nienhaus, G.U.; Simmet, T.; Debatin, K.M.; Weiner, G.J.; Fabricius, D.
Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion
Blood
115
1156-1165
2010
Homo sapiens
Thiery, J.; Keefe, D.; Saffarian, S.; Martinvalet, D.; Walch, M.; Boucrot, E.; Kirchhausen, T.; Lieberman, J.
Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis
Blood
115
1582-1593
2010
Homo sapiens
Efimova, O.V.; Kelley, T.W.
Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway
BMC Immunol.
10
59
2009
Homo sapiens
Darrah, E.; Rosen, A.
Granzyme B cleavage of autoantigens in autoimmunity
Cell Death Differ.
17
624-632
2010
Homo sapiens
Xie, D.; Hai, B.; Xie, X.; Liu, L.; Ayello, J.; Ma, X.; Zhang, J.
Peripheral CD4+CD8+cells are the activated T cells expressed granzyme B (GrB), Foxp3, interleukin 17 (IL-17), at higher levels in Th1/Th2 cytokines
Cell. Immunol.
259
157-164
2009
Homo sapiens
Li, P.; Zheng, G.; Yang, Y.; Zhang, C.; Xiong, P.; Xu, Y.; Fang, M.; Tan, Z.; Zheng, F.; Gong, F.
Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis
Cell. Mol. Life Sci.
67
3197-3208
2010
Homo sapiens
Grassi, M.; Capello, F.; Bertolino, L.; Seia, Z.; Pippione, M.
Identification of granzyme B-expressing CD-8-positive T cells in lymphocytic inflammatory infiltrate in cutaneous lupus erythematosus and in dermatomyositis
Clin. Exp. Dermatol.
34
910-914
2009
Homo sapiens
Hodge, S.; Hodge, G.; Ahern, J.; Liew, C.L.; Hopkins, P.; Chambers, D.C.; Reynolds, P.N.; Holmes, M.
Increased levels of T cell granzyme b in bronchiolitis obliterans syndrome are not suppressed adequately by current immunosuppressive regimens
Clin. Exp. Immunol.
158
230-236
2009
Homo sapiens
Hagn, M.; Ebel, V.; Sontheimer, K.; Schwesinger, E.; Lunov, O.; Beyer, T.; Fabricius, D.; Barth, T.F.; Viardot, A.; Stilgenbauer, S.; Hepp, J.; Scharffetter-Kochanek, K.; Simmet, T.; Jahrsdoerfer, B.
CD5(+) B cells from individuals with systemic lupus erythematosus express granzyme B
Eur. J. Immunol.
40
2060-2069
2010
Homo sapiens
Aguilo, J.I.; Anel, A.; Catalan, E.; Sebastian, A.; Acin-Perez, R.; Naval, J.; Wallich, R.; Simon, M.M.; Pardo, J.
Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation
Immunol. Cell Biol.
88
545-554
2010
Mus musculus
Kurschus, F.; Jenne, D.
Delivery and therapeutic potential of human granzyme B
Immunol. Rev.
235
159-171
2010
Homo sapiens, Mus musculus
D'Eliseo, D.; Pisu, P.; Romano, C.; Tubaro, A.; De Nunzio, C.; Morrone, S.; Santoni, A.; Stoppacciaro, A.; Velotti, F.
Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion
Int. J. Cancer
127
1283-1294
2009
Homo sapiens
D'Angelo, M.E.; Bird, P.I.; Peters, C.; Reinheckel, T.; Trapani, J.A.; Sutton, V.R.
Cathepsin H is an additional convertase of pro-granzyme B
J. Biol. Chem.
285
20514-20519
2010
Homo sapiens, Mus musculus
Cai, S.F.; Fehniger, T.A.; Cao, X.; Mayer, J.C.; Brune, J.D.; French, A.R.; Ley, T.J.
Differential expression of granzyme B and C in murine cytotoxic lymphocytes
J. Immunol.
182
6287-6297
2009
Mus musculus
Wang, T.; Lee, M.H.; Johnson, T.; Allie, R.; Hu, L.; Calabresi, P.A.; Nath, A.
Activated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers
J. Neurosci.
30
5020-5027
2010
Homo sapiens
Boivin, W.A.; Cooper, D.M.; Hiebert, P.R.; Granville, D.J.
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma
Lab. Invest.
89
1195-1220
2009
Homo sapiens, Mus musculus
van Tetering, G.; Bovenschen, N.; Meeldijk, J.; van Diest, P.J.; Vooijs, M.
Cleavage of Notch1 by granzyme B disables its transcriptional activity
Biochem. J.
437
313-322
2011
Homo sapiens
Tsai, T.; Lin, W.; Yang, S.; Cheng, W.; Cheng, E.; Lee, M.; Chong, K.; Chen, C.
Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition
BMC Dev. Biol.
10
88
2010
Mus musculus
Chaitanya, G.V.; Eeka, P.; Munker, R.; Alexander, J.S.; Babu, P.P.
Role of cytotoxic protease granzyme-b in neuronal degeneration during human stroke
Brain Pathol.
21
16-30
2011
Homo sapiens
Shah, D.; Kiran, R.; Wanchu, A.; Bhatnagar, A.
Soluble granzyme B and cytotoxic T lymphocyte activity in the pathogenesis of systemic lupus erythematosus
Cell. Immunol.
269
16-21
2011
Homo sapiens
Ilzecka, J.
Granzymes A and B levels in serum of patients with amyotrophic lateral sclerosis
Clin. Biochem.
44
650-653
2011
Homo sapiens
Afonina, I.; Cullen, S.; Martin, S.
Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B
Immunol. Rev.
235
105-116
2010
Homo sapiens
Omoto, Y.; Yamanaka, K.; Tokime, K.; Kitano, S.; Kakeda, M.; Akeda, T.; Kurokawa, I.; Gabazza, E.C.; Tsutsui, H.; Katayama, N.; Yamanishi, K.; Nakanishi, K.; Mizutani, H.
Granzyme B is a novel interleukin-18 converting enzyme
J. Dermatol. Sci.
59
129-135
2010
Homo sapiens
Gehrmann, M.; Doss, B.T.; Wagner, M.; Zettlitz, K.A.; Kontermann, R.E.; Foulds, G.; Pockley, A.G.; Multhoff, G.
A novel expression and purification system for the production of enzymatic and biologically active human granzyme B
J. Immunol. Methods
371
8-17
2011
Homo sapiens
Niland, B.; Miklossy, G.; Banki, K.; Biddison, W.E.; Casciola-Rosen, L.; Rosen, A.; Martinvalet, D.; Lieberman, J.; Perl, A.
Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients
J. Immunol.
184
4025-4032
2010
Homo sapiens
Hartmann, W.; Marsland, B.J.; Otto, B.; Urny, J.; Fleischer, B.; Korten, S.
A novel and divergent role of granzyme A and B in resistance to helminth infection
J. Immunol.
186
2472-2481
2011
Mus musculus
Haile, Y.; Simmen, K.C.; Pasichnyk, D.; Touret, N.; Simmen, T.; Lu, J.Q.; Bleackley, R.C.; Giuliani, F.
Granule-derived granzyme B mediates the vulnerability of human neurons to T cell-induced neurotoxicity
J. Immunol.
187
4861-4872
2011
Homo sapiens
Salti, S.M.; Hammelev, E.M.; Grewal, J.L.; Reddy, S.T.; Zemple, S.J.; Grossman, W.J.; Grayson, M.H.; Verbsky, J.W.
Granzyme B regulates antiviral CD8+ T cell responses
J. Immunol.
187
6301-6309
2011
Mus musculus
Kapelski, S.; de Almeida, M.; Fischer, R.; Barth, S.; Fendel, R.
Antimalarial activity of granzyme B and its targeted delivery by a granzyme B-single-chain Fv fusion protein
Antimicrob. Agents Chemother.
59
669-672
2015
Homo sapiens (P10144)
Arias, M.A.; Jimenez de Baguees, M.P.; Aguilo, N.; Menao, S.; Hervas-Stubbs, S.; de Martino, A.; Alcaraz, A.; Simon, M.M.; Froelich, C.J.; Pardo, J.
Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis
Cell Rep.
8
420-429
2014
Mus musculus (P04187), Mus musculus, Mus musculus B6 (P04187)
Mellor-Heineke, S.; Villanueva, J.; Jordan, M.B.; Marsh, R.; Zhang, K.; Bleesing, J.J.; Filipovich, A.H.; Risma, K.A.
Elevated granzyme B in cytotoxic lymphocytes is a signature of immune activation in hemophagocytic lymphohistiocytosis
Front. Immunol.
4
72
2013
Homo sapiens (P10144), Homo sapiens
Catalan, E.; Jaime-Sanchez, P.; Aguilo, N.; Simon, M.M.; Froelich, C.J.; Pardo, J.
Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim dependent fashion
J. Biol. Chem.
290
6868-6877
2015
Mus musculus (P04187), Mus musculus, Mus musculus B6 (P04187)
Bhela, S.; Kempsell, C.; Manohar, M.; Dominguez-Villar, M.; Griffin, R.; Bhatt, P.; Kivisakk-Webb, P.; Fuhlbrigge, R.; Kupper, T.; Weiner, H.; Baecher-Allan, C.
Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo tregs in multiple sclerosis and in response to IL-6
J. Immunol.
194
2180-2189
2015
Homo sapiens (P10144), Homo sapiens
Kim, M.S.; Buisson, L.A.; Heathcote, D.A.; Hu, H.; Braddock, D.C.; Barrett, A.G.; Ashton-Rickardt, P.G.; Snyder, J.P.
Approaches to design non-covalent inhibitors for human granzyme B (hGrB)
Org. Biomol. Chem.
12
8952-8965
2014
Homo sapiens (P10144), Homo sapiens
Boivin, W.A.; Shackleford, M.; Vanden Hoek, A.; Zhao, H.; Hackett, T.L.; Knight, D.A.; Granville, D.J.
Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-beta1
PLoS ONE
7
e33163
2012
Homo sapiens (P10144)
Oberoi, P.; Jabulowsky, R.A.; Baehr-Mahmud, H.; Wels, W.S.
EGFR-targeted granzyme B expressed in NK cells enhances natural cytotoxicity and mediates specific killing of tumor cells
PLoS ONE
8
e61267
2013
Homo sapiens (P10144), Homo sapiens
Li, X.; Zhang, G.; An, G.; Liu, S.; Lai, Y.
Expression, purification and anticancer analysis of GST-tagged human perforin and granzyme B proteins in human laryngeal cancer Hep-2 cells
Protein Expr. Purif.
95
38-43
2014
Homo sapiens (P10144), Homo sapiens
Ho, P.; Ede, C.; Chen, Y.Y.
Modularly constructed synthetic granzyme B molecule enables interrogation of intracellular proteases for targeted cytotoxicity
ACS Synth. Biol.
6
1484-1495
2017
Homo sapiens (P10144), Homo sapiens
Kapelski, S.; De Almeida, M.; Fischer, R.; Barth, S.; Fendel, R.
Antimalarial activity of granzyme B and its targeted delivery by a granzyme B-single-chain Fv fusion protein
Antimicrob. Agents Chemother.
59
669-672
2015
Homo sapiens (P10144)
Dotiwala, F.; Sen Santara, S.; Binker-Cosen, A.A.; Li, B.; Chandrasekaran, S.; Lieberman, J.
Granzyme B disrupts central metabolism and protein synthesis in bacteria to promote an immune cell death program
Cell
171
1125-1137
2017
Homo sapiens (P10144), Homo sapiens
Kumar, A.; Perdomo, M.F.; Kantele, A.; Hedman, L.; Hedman, K.; Franssila, R.
Granzyme B mediated function of parvovirus B19-specific CD4+ T cells
Clin. Transl. Immunology
4
e39
2015
Homo sapiens (P10144)
Cimini, F.A.; DEliseo, D.; Barchetta, I.; Bertoccini, L.; Velotti, F.; Cavallo, M.G.
Increased circulating granzyme B in type 2 diabetes patients with low-grade systemic inflammation
Cytokine
115
104-108
2019
Homo sapiens (P10144), Homo sapiens
Mouchacca, P.; Chasson, L.; Frick, M.; Foray, C.; Schmitt-Verhulst, A.; Boyer, C.
Visualization of granzyme B-expressing CD8 T cells during primary and secondary immune responses to Listeria monocytogenes
Immunology
145
24-33
2015
Mus musculus (P04187), Mus musculus C57BL/6 (P04187)
Yang, J.; Pemberton, A.; Morrison, W.; Connelley, T.
Granzyme B is an essential mediator in CD8 T cell killing of theileria parva-infected cells
Infect. Immun.
87
e00386-18
2019
Bos taurus (F1MTF4), Bos taurus, Bos taurus Holstein-Friesian (F1MTF4)
Darrah, E.; Kim, A.; Zhang, X.; Boronina, T.; Cole, R.N.; Fava, A.; Giles, J.T.; Bingham III, C.O.; Chalmers, M.J.; Griffin, P.R.; Sadegh-Nasseri, S.; Rosen, A.
Proteolysis by granzyme B enhances presentation of autoantigenic peptidylarginine deiminase 4 epitopes in rheumatoid arthritis
J. Proteome Res.
16
355-365
2017
Homo sapiens
Wang, L.; Jiang, S.; Xiao, L.; Chen, L.; Zhang, Y.; Tong, J.
Inhibition of granzyme B activity blocks inflammation induced by lipopolysaccharide through regulation of endoplasmic reticulum stress signaling in NK92 cells
Mol. Med. Rep.
18
580-586
2018
Homo sapiens (P10144)
Fu, Z.; Thorpe, M.; Akula, S.; Hellman, L.
Asp-ase activity of the Opossum granzyme B supports the role of granzyme B as part of anti-viral immunity already during early mammalian evolution
PLoS ONE
11
e0154886
2016
Monodelphis domestica, Homo sapiens (P10144), Homo sapiens
Marcet-Palacios, M.; Ewen, C.; Pittman, E.; Duggan, B.; Carmine-Simmen, K.; Fahlman, R.; Bleackley, R.
Design and characterization of a novel human granzyme B inhibitor
Protein Eng. Des. Sel.
28
9-17
2015
Homo sapiens (P10144), Homo sapiens
Shevtsov, M.; Stangl, S.; Nikolaev, B.; Yakovleva, L.; Marchenko, Y.; Tagaeva, R.; Sievert, W.; Pitkin, E.; Mazur, A.; Tolstoy, P.; Galibin, O.; Ryzhov, V.; Steiger, K.; Smirnov, O.; Khachatryan, W.; Chester, K.; Multhoff, G.
Granzyme B functionalized nanoparticles targeting membrane Hsp70-positive tumors for multimodal cancer theranostics
Small
15
e1900205
2019
Homo sapiens (P10144)
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