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Literature summary for 3.4.21.79 extracted from

  • Chamberlain, C.M.; Granville, D.J.
    The role of Granzyme B in atheromatous diseases (2007), Can. J. Physiol. Pharmacol., 85, 89-95.
    View publication on PubMed
Search for more literature for 3.4.21.79

Activating Compound

Activating Compound Comment Organism Structure
cathepsin C proteolytically activates in cytotoxic granules Homo sapiens

Application

Application Comment Organism
medicine granzyme B may play a key role in ateromatous diseases. Role in cardiac allograft vasculopathy and atherosclerosis Mus musculus
medicine granzyme B may play a key role in ateromatous diseases. Role in cardiac allograft vasculopathy and atherosclerosis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information granzyme B-deficient mice possess a normal phenotype, with the exception of reduced CTL-mediated target cell apoptosis, antiviral responses, and tumor cell clearance. Treg cells from granzyme B-deficient mice can not suppress immune responses as effectively as Treg cells from wild-type mice. Granzyme B-deficient recipient mice exhibit reduced allograft vasculopathy and increased susceptibility to allgergen-induced asthma. Hearts from 129J donor mice transplanted into granzyme B-KO mice exhibit significantly smaller lesions and luminal narrowing compared with wild-type recipients Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
(S)-3-((2S,5S)-5-((2S,3S)-2-acetamido-3-methylpentanamido)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamido)-4-oxobutanoic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood basophil Homo sapiens
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keratinocyte
-
 Homo sapiens
-
leukocyte
-
 Homo sapiens
-
macrophage
-
 Homo sapiens
-
additional information increased protein levels in all regions of vessels with advanced atherosclerosis, i.e., superficial intima, deep intima, and the media. In the intima granzyme B is present within lipid-rich regions in which it localizes to TUNEL-positive foam cells of atherosclerotic plaques. In allograft vasculopathy increase of protein levels only in the deep intima Homo sapiens
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additional information Treg cell Mus musculus
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placenta perforin-independent expression Homo sapiens
-
smooth muscle cell perforin-independent expression Homo sapiens
-
testis perforin-independent expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aggrecan proteoglycan + H2O
-
 Homo sapiens ?
-
 ?
autoantigen + H2O
-
 Homo sapiens ?
-
 ?
BID + H2O
-
 Homo sapiens truncated BID + ?
-
 ?
Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
lamin + H2O
-
 Homo sapiens ?
-
 ?
Vitronectin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cytotoxic T-lymphocyte-associated gene transcript-1
-
 Mus musculus