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Literature summary for 3.4.21.79 extracted from

  • Prakash, M.D.; Bird, C.H.; Bird, P.I.
    Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement (2009), Immunol. Cell Biol., 87, 249-254.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information an extracellular activator of granzyme B may exist Homo sapiens

Application

Application Comment Organism
medicine the release of granzyme B through two routes from unconjugated cytotoxic lymphocytes suggests that it functions outside the cell and may contribute to pathology in cases of immune dysregulation, such as familial hemophagocytic lymphohistiocytosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2S,5S)-N-((1H-1,2,3-triazol-4-yl)methyl)-5-((3S,4S)-3-(2-(benzo[b]thiophen-3-yl)acetamido)-4-methyl-2-oxohexylamino)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamide specific granzyme B inhibitor Homo sapiens
PI-9 granzyme B forms a specific SDS-stable complex with its cognate inhibitor, PI-9 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
cytotoxic T-lymphocyte cell line a proportion of granzyme B is constitutively secreted by cytotoxic T lymphocytes in the absence of target cell engagement. Cytotoxic T lymphocyte primarily secrete inactive granzyme B zymogen, bypassing the granules. They produce less granzyme B than natural killer cells, but secrete much more (58%) than they store Homo sapiens
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additional information granzyme B is not detectable in K562 cell-conditioned medium Homo sapiens
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natural killer cell a proportion of granzyme B is constitutively secreted by natural killer cells in the absence of target cell engagement. The protease is primarily released in an active form through secretory granules except in YT cells that mainly release inactive granzyme B zymogen. A-NK and NK92 cells secrete a comparatively small proportion of their granzyme B (ca. 10 and 0.3% of the total per hour, respectively), whereas YT cells release about 29% Homo sapiens
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Synonyms

Synonyms Comment Organism
GrB
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Homo sapiens