Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | an extracellular activator of granzyme B may exist | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | the release of granzyme B through two routes from unconjugated cytotoxic lymphocytes suggests that it functions outside the cell and may contribute to pathology in cases of immune dysregulation, such as familial hemophagocytic lymphohistiocytosis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S,5S)-N-((1H-1,2,3-triazol-4-yl)methyl)-5-((3S,4S)-3-(2-(benzo[b]thiophen-3-yl)acetamido)-4-methyl-2-oxohexylamino)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamide | specific granzyme B inhibitor | Homo sapiens | |
PI-9 | granzyme B forms a specific SDS-stable complex with its cognate inhibitor, PI-9 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cytotoxic T-lymphocyte cell line | a proportion of granzyme B is constitutively secreted by cytotoxic T lymphocytes in the absence of target cell engagement. Cytotoxic T lymphocyte primarily secrete inactive granzyme B zymogen, bypassing the granules. They produce less granzyme B than natural killer cells, but secrete much more (58%) than they store | Homo sapiens | - |
additional information | granzyme B is not detectable in K562 cell-conditioned medium | Homo sapiens | - |
natural killer cell | a proportion of granzyme B is constitutively secreted by natural killer cells in the absence of target cell engagement. The protease is primarily released in an active form through secretory granules except in YT cells that mainly release inactive granzyme B zymogen. A-NK and NK92 cells secrete a comparatively small proportion of their granzyme B (ca. 10 and 0.3% of the total per hour, respectively), whereas YT cells release about 29% | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GrB | - |
Homo sapiens |