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Literature summary for 3.4.21.79 extracted from

  • D'Eliseo, D.; Pisu, P.; Romano, C.; Tubaro, A.; De Nunzio, C.; Morrone, S.; Santoni, A.; Stoppacciaro, A.; Velotti, F.
    Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion (2009), Int. J. Cancer, 127, 1283-1294.
    View publication on PubMed
Search for more literature for 3.4.21.79

Inhibitors

Inhibitors Comment Organism Structure
Z-Ala-Ala-Asp-CH2Cl
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 Western blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Vitronectin + H2O Homo sapiens Grb expressed in human bladder cancer cell lines 1512 and RT112 cleave vitronectin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bladder GrB is expressed in 7 out of 12 bladder cancer cell lines Homo sapiens
-
urothelium GrB is expressed, in absence of perforin in urothelial carcinoma cells. Significant differences are found between GrB expression and both increasing pathological tumor spreading and high-grade vs. low-grade pTa tumors Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ace-Ile-Glu-Pro-Asp-p-nitroanilide + H2O
-
 Homo sapiens Ace-Ile-Glu-Pro-Asp + p-nitroaniline
-
 ?
Vitronectin + H2O Grb expressed in human bladder cancer cell lines 1512 and RT112 cleave vitronectin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
granzyme B
-
 Homo sapiens
GrB
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens GrB in urothelial cancer tissues is concentrated at the cancer invasion front and is expressed in neoplastic cells undergoing epithelial-mesenchymal transition, a key event in carcinoma invasion up

General Information

General Information Comment Organism
malfunction inhibition or downregulation of GrB suppresses bladder cancer cell invasion in vitro Homo sapiens
physiological function GrB, via extracellular matrix degradation, contributes to the establishment of the urothelial carcinoma invasive phenotype Homo sapiens