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Literature summary for 3.4.21.79 extracted from

  • Wang, L.; Jiang, S.; Xiao, L.; Chen, L.; Zhang, Y.; Tong, J.
    Inhibition of granzyme B activity blocks inflammation induced by lipopolysaccharide through regulation of endoplasmic reticulum stress signaling in NK92 cells (2018), Mol. Med. Rep., 18, 580-586 .
    View publication on PubMed
Search for more literature for 3.4.21.79

Inhibitors

Inhibitors Comment Organism Structure
serine protease inhibitor A3N i.e. serpin A3N or SA3N, an extracellular inhibitor of GrB possessing multiple biological functions, including the attenuaxadtion of muscular dystrophy in mice, neuropathic pain, and GrB-mediated decorin cleavage and rupture. It also induces neuroprotection in vitro and in vivo. Role of GrB inhibitor SA3N on Escherichia coli LPS-induced inflammation in NK-92 cells. SA3N pretreatment prevents the LPS-induced changes in expression levels of GRP78, CHOP, NF-kappaB, and IkappaBalpha proteins. Also SA3N pretreatment prevents the expression and exocytosis of GrB by LPS Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P10144
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-

Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte
-
 Homo sapiens
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keratinocyte
-
 Homo sapiens
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macrophage
-
 Homo sapiens
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additional information granzyme B (GrB) belongs to a family of serine proteases that are expressed in the granules of activated CTLs and NK cells that induce apoptosis. GrB is also expressed in non-lymphoid lineage cells, including chondrocytes, neutroxadphils, keratinocytes, and macrophages Homo sapiens
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natural killer cell
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 Homo sapiens
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neutrophil
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 Homo sapiens
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NK-92 cell
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 Homo sapiens
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T-lymphocyte cytotoxic T lymphocytes Homo sapiens
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Synonyms

Synonyms Comment Organism
GrB
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens serine protease inhibitor A3N, i.e. serpin A3N or SA3N, an extracellular inhibitor of GrB possessing multiple biological functions, including the attenuaxadtion of muscular dystrophy in mice, neuropathic pain, and GrB-mediated decorin cleavage and rupture. It also induces neuroprotection in vitro and in vivo. Role of GrB inhibitor SA3N on Escherichia coli LPS-induced inflammation in NK-92 cells. SA3N pretreatment prevents the LPS-induced changes in expression levels of GRP78, CHOP, NF-kappaB and IkappaBalpha proteins. Also SA3N pretreatment prevents the expression and exocytosis of GrB by LPS down

General Information

General Information Comment Organism
malfunction inhibition of granzyme B activity blocks inflammation induced by lipopolysaccharide through regulation of endoplasmic reticulum stress signaling in NK92 cells. Inhibition of GrB activity suppresses the changes of NF-kappaB and IkappaBalpha expression levels induced by LPS as part of endoplasmic reticulum stress Homo sapiens
physiological function granzyme B (GrB) is a serine protease that is expressed in the lytic granules of natural killer (NK) cells and cytotoxic T lymphocytes (CTL), it plays a role in target cell apopxadtosis and a non-cytotoxic role in inflammation Homo sapiens