Literature summary for 3.4.21.79 extracted from

Estebanez-Perpina, E.; Fuentes-Prior, P.; Belorgey, D.; Braun, M.; Kiefersauer, R.; Maskos, K.; Huber, R.; Rubin, H.; Bode, W.
Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue (2000), Biol. Chem., 381, 1203-1214.

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Cloned(Commentary)

Cloned (Comment)	Organism
leukocyte cDNA amplified by PCR, expressed in a baculovirus system in Sf9 cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	triggers apoptosis in target cells by activating the caspase pathway, implicated in the etiology of rheumatoid arthritis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant enzyme	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	triggers apoptosis in target cells by activating the caspase pathway, implicated in the etiology of rheumatoid arthritis	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
dimer	-	Homo sapiens

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Release 2023.1 (January 2023)