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Literature summary for 3.4.21.79 extracted from
- Granzyme B cleavage of autoantigens in autoimmunity (2010), Cell Death Differ., 17, 624-632.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| medullary breast carcinoma cell | in medullary carcinoma of the breast (MCB), GrB-expressing cytotoxic T cells are found in large numbers, often nearby apoptotic tumor cells | Homo sapiens | - |
| serum | levels of GrB in the serum and synovial fluid of rheumatoid arthritis patients is strikingly associated with the severity of erosive joint disease | Homo sapiens | - |
| synovial tissue | levels of GrB in the serum and synovial fluid of rheumatoid arthritis patients is strikingly associated with the severity of erosive joint disease | Homo sapiens | - |
| thymus | granzyme B and its substrate acetylcholin receptor epsilon subunit are aberrantly expressed in thymus from patients with Myasthenia gravis | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine receptor epsilon subunit + H2O | - |
Homo sapiens | ? | - |
? |  |
| AHNAK + H2O | autoantigen cleaved by granzyme B, function of substrate: calcium signalling, associated disease: systemic lupus erythematosus | Homo sapiens | ? | - |
? | |
| alanyl tRNA synthetase + H2O | autoantigen cleaved by granzyme B, function of substrate: translation, associated disease: myositis | Homo sapiens | ? | - |
? | |
| alpha-fodrin + H2O | autoantigen cleaved by granzyme B, function of substrate: cytoskeletal protein, associated disease: Sjörgen's syndrome | Homo sapiens | ? | - |
? | |
| beta-actin + H2O | GrB cleavage fragments of beta-actin are detected in medullary carcinoma of the breast tumor lysates, suggesting that CTL-mediated death of medullary carcinoma of the breast tumor cells and actin redistribution may have a function in the generation of autoimmunity to beta-actin | Homo sapiens | ? | - |
? | |
| centromere protein B + H2O | autoantigen cleaved by granzyme B, function of substrate: mitosis, associated disease: Scleroderma | Homo sapiens | ? | - |
? | |
| centromere protein C + H2O | autoantigen cleaved by granzyme B, function of substrate: mitosis, associated disease: Scleroderma | Homo sapiens | ? | - |
? | |
| chromodomain helicase DNA binding 4 + H2O | autoantigen cleaved by granzyme B, function of substrate: gene expression, associated disease: myositis | Homo sapiens | ? | - |
? | |
| DNA-PK catalytic subunit + H2O | autoantigen cleaved by granzyme B, function of substrate: DNA repair, associated disease: myositis | Homo sapiens | ? | - |
? | |
| fibrillarin + H2O | autoantigen cleaved by granzyme B, function of substrate: rRNA processing, associated disease: Scleroderma | Homo sapiens | ? | - |
? | |
| glutamate receptor subunit 3 + H2O | autoantigen cleaved by granzyme B, function of substrate: Glutamate receptor, associated disease: Rasmussen's encephalitis | Homo sapiens | ? | - |
? | |
| hepatitis antigen lamin B + H2O | cleavage of autoimmune hepatitis antigen lamin B by GrA and B causes disruption of the nuclear lamina, by uncoupling lamin B from its nuclear localisation signal | Homo sapiens | ? | - |
? | |
| histidyl tRNA synthetase + H2O | autoantigen cleaved by granzyme B, function of substrate: translation, associated disease: myositis | Homo sapiens | ? | - |
? | |
| human endogenous retrovirus K-10 gag + H2O | autoantigen cleaved by granzyme B, function of substrate: endogenous retrovirus, associated disease: systemic lupus erythematosus | Homo sapiens | ? | - |
? | |
| Ki-67 + H2O | autoantigen cleaved by granzyme B, function of substrate: proliferation, associated disease: myositis | Homo sapiens | ? | - |
? | |
| Ku-70 + H2O | autoantigen cleaved by granzyme B, function of substrate: DNA repair, associated disease: myositis | Homo sapiens | ? | - |
? | |
| La/SSB + H2O | the SS nuclear autoantigen La/SSB is a substrate for GrB | Homo sapiens | ? | - |
? | |
| additional information | tetrapeptide substrate specificity of human GrB: In addition to the requirement for aspartic acid in the P1 position, P4 is specific for Ile, Val, and Leu, whereas P3 and P2 are able to accommodate a wider range of amino acids | Homo sapiens | ? | - |
? | |
| additional information | the GrB cleavage sites defined within autoantigens reveal several features: first, all have Ile, Leu, or Val in P4 and are cleaved after the P1 aspartic acid. Second, amino acids in the P2 and P3 positions in autoantigens are almost universally favored by human GrB, but not tolerated by caspases (e.g. proline in P2) | Homo sapiens | ? | - |
? | |
| nuclear mitotic apparatus protein 1 + H2O | autoantigen cleaved by granzyme B, function of substrate: mitosis, associated disease: Sjörgen's syndrome | Homo sapiens | ? | - |
? | |
| nucleolus organizing region 90 kDa (NOR-90/UBF) + H2O | autoantigen cleaved by granzyme B, function of substrate: transcription factor, associated disease: Scleroderma | Homo sapiens | ? | - |
? | |
| nucleophosmin (B23) + H2O | autoantigen cleaved by granzyme B, function of substrate: rRNA processing, associated disease: Scleroderma | Homo sapiens | ? | - |
? | |
| PMScl/EXOSC10 + H2O | autoantigen cleaved by granzyme B, function of substrate: mRNA degradation, associated disease: myositis/Scleroderma | Homo sapiens | ? | - |
? | |
| poly(ADP)ribose polymerase 1 (PARP1) + H2O | autoantigen cleaved by granzyme B, function of substrate: ribosylation, associated disease: systemic lupus erythematosus | Homo sapiens | ? | - |
? | |
| postmeiotic segregation 1 + H2O | autoantigen cleaved by granzyme B, function of substrate: DNA mismatch repair, associated disease: myositis | Homo sapiens | ? | - |
? | |
| postmeiotic segregation 2 + H2O | autoantigen cleaved by granzyme B, function of substrate: DNA mismatch repair, associated disease: myositis | Homo sapiens | ? | - |
? | |
| pyruvate dehydrogenase complex E2 (PDC-E2) + H2O | autoantigen cleaved by granzyme B, function of substrate: acetyl CoA synthesis, associated disease: primary biliary cirrhosis | Homo sapiens | ? | - |
? | |
| RNA polymerase I + H2O | autoantigen cleaved by granzyme B, function of substrate: transcription, associated disease: Scleroderma | Homo sapiens | ? | - |
? | |
| RNA polymerase II + H2O | autoantigen cleaved by granzyme B, function of substrate: transcription, associated disease: Scleroderma | Homo sapiens | ? | - |
? | |
| signal recognition particle 72 kDa + H2O | autoantigen cleaved by granzyme B, function of substrate: translation, associated disease: myositis, systemic lupus erythematosus | Homo sapiens | ? | - |
? | |
| topoisomerase 1 + H2O | autoantigen cleaved by granzyme B, function of substrate: transcription, associated disease: Scleroderma | Homo sapiens | ? | - |
? | |
| U1 small nuclear ribonucleoprotein 70 kDa + H2O | autoantigen cleaved by granzyme B, function of substrate: RNA processing, associated disease: systemic lupus erythematosus, Scleroderma, myositis | Homo sapiens | ? | - |
? | |
| ubiquitin fusion degradation 2 + H2O | autoantigen cleaved by granzyme B, function of substrate: ubiquitination, associated disease: Scleroderma | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| granzyme B | - |
Homo sapiens |
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