Literature summary for 3.4.21.79 extracted from

Duggan, B.L.; Cabilio, N.R.; Dickie, P.; Witmer, J.; Goping, I.S.; Underhill, D.A.; Bleackley, R.C.
A novel lineage-specific hypersensitive site is essential for position independent granzyme B expression in transgenic mice (2008), Biochem. Biophys. Res. Commun., 368, 357-363.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	induction of granzyme B by a DNase1 hypersensitive site 3.9 kb upstream of the transcription start site of granzyme B	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
CTLL R8 cell line stably transfected with GFP reporter constructs	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	deletion of the DNase1 hypersensitive site upstream of the granzyme B gene results in a 10fold reduction in expression	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C57 and Balb/C mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	in activated but not resting primary CD8+ T cells, a DNase1 hypersensitive site pesent upstream of the granzyme B gene. Thymocytes do not express granzyme B. MTL 2.8.2 cell line constitutively expresses granzyme B at a high level. CTLL R8 cell line constitutively expresses endogenous granzyme B gene	Mus musculus	-
splenocyte	-	Mus musculus	-

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Release 2023.1 (January 2023)