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Literature summary for 3.4.21.79 extracted from

  • Cimini, F.A.; DEliseo, D.; Barchetta, I.; Bertoccini, L.; Velotti, F.; Cavallo, M.G.
    Increased circulating granzyme B in type 2 diabetes patients with low-grade systemic inflammation (2019), Cytokine, 115, 104-108 .
    View publication on PubMed
Search for more literature for 3.4.21.79

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Homo sapiens
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-

Organism

Organism UniProt Comment Textmining
Homo sapiens P10144
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-

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
 Homo sapiens
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natural killer cell
-
 Homo sapiens
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T-lymphocyte cytotoxic T lymphocytes Homo sapiens
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Synonyms

Synonyms Comment Organism
GrB
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens increased circulating granzyme B in type 2 diabetes patients with low-grade systemic inflammation up

General Information

General Information Comment Organism
malfunction increased circulating granzyme B in type 2 diabetes patients with low-grade systemic inflammation, correlated with unfavorable inflammatory profile, as described by elevated levels of validated adipokines such as interleukin-6, TNF-alpha, and WISP1. Multivariate linear regression analysis shows that increased GrB is associated with type 2 diabetes diagnosis independently from possible confounders Homo sapiens
physiological function granzyme B (GrB) is a serine protease produced by some leukocytes, including cytotoxic lymphocytes and macrophages, that exerts both intracellular apoptotic function and extracellular functions, leading to tissue injury, inflammation and repair. Role for GrB in the pathogenesis of several chronic inflammatory diseases Homo sapiens