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Literature summary for 3.4.21.79 extracted from

  • Andrade, F.; Fellows, E.; Jenne, D.E.; Rosen, A.; Young, C.S.
    Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition (2007), EMBO J., 26, 2148-2157.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine granzymes can mediate antiviral activity through direct cleavage of viral substrates. Different granzymes have synergistic functions to outflank viral defenses that block host antiviral activities Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(S)-3-((2S,5S)-5-((2S,3S)-2-acetamido-3-methylpentanamido)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamido)-4-oxobutanoic acid GzmB inhibitor Homo sapiens
adenovirus 100K assembly protein inhibits gzmB, gzmH relieves gzmB inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
gzmB and gzmH Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
additional information LAK cells, gzmB and gzmH present Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenovirus 100K assembly protein + H2O gzmB and gzmH Homo sapiens ?
-
?
adenovirus DNA-binding protein + H2O gzmB and gzmH. Direct cleavage of DNA-binding protein by gzmH is a critical component of the cytotoxic antiviral response against adenovirus, which slows down DNA viral replication. Cleaved by gzmH at multiple sites, most efficient cleavage at Met118, when this site is mutated, gzmH instead cleaves at Phe121 Homo sapiens ?
-
?
caspase-3 + H2O gzmB Homo sapiens procaspase-3 + ?
-
?

Synonyms

Synonyms Comment Organism
Granzyme H
-
Homo sapiens
GzmB
-
Homo sapiens
GzmH
-
Homo sapiens