Application | Comment | Organism |
---|---|---|
medicine | granzymes can mediate antiviral activity through direct cleavage of viral substrates. Different granzymes have synergistic functions to outflank viral defenses that block host antiviral activities | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-3-((2S,5S)-5-((2S,3S)-2-acetamido-3-methylpentanamido)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamido)-4-oxobutanoic acid | GzmB inhibitor | Homo sapiens | |
adenovirus 100K assembly protein | inhibits gzmB, gzmH relieves gzmB inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
gzmB and gzmH | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | LAK cells, gzmB and gzmH present | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenovirus 100K assembly protein + H2O | gzmB and gzmH | Homo sapiens | ? | - |
? | |
adenovirus DNA-binding protein + H2O | gzmB and gzmH. Direct cleavage of DNA-binding protein by gzmH is a critical component of the cytotoxic antiviral response against adenovirus, which slows down DNA viral replication. Cleaved by gzmH at multiple sites, most efficient cleavage at Met118, when this site is mutated, gzmH instead cleaves at Phe121 | Homo sapiens | ? | - |
? | |
caspase-3 + H2O | gzmB | Homo sapiens | procaspase-3 + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Granzyme H | - |
Homo sapiens |
GzmB | - |
Homo sapiens |
GzmH | - |
Homo sapiens |