Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | no GzB activity in CTL or NK92 effector cells, but activity rapidly becomes detectable throughout the target cytoplasm after effector-target engagement. Lack of GzB activity in Jurkat cells following intrinsic and extrinsic apoptotic stimuli | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | detection of target GzB activity followed by caspase 3 activation provides a unique readout of a potentially lethal injury delivered by cytotoxic lymphocytes | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | CD8+ T cell | Homo sapiens | - |
additional information | no GzB activity in CTL or NK92 effector cells. Lack of GzB activity in Jurkat cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
VGPDFGR + H2O | - |
Homo sapiens | VGPD + FGR | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GzB | - |
Homo sapiens |