Literature summary for 3.4.21.79 extracted from

Mellor-Heineke, S.; Villanueva, J.; Jordan, M.B.; Marsh, R.; Zhang, K.; Bleesing, J.J.; Filipovich, A.H.; Risma, K.A.
Elevated granzyme B in cytotoxic lymphocytes is a signature of immune activation in hemophagocytic lymphohistiocytosis (2013), Front. Immunol., 4, 72.

Search for more literature for 3.4.21.79

Application

Application	Comment	Organism
diagnostics	increased detection of the enzyme in cytotoxic T lymphocytes and natural killer cells are an immune signature for lymphocyte activation in hemophagocytic lymphohistiocytosis, irrespective of genetic subtype, and may also be a useful measure of immune activation in other related conditions	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P10144	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
natural killer cell	GrB expressing cells are increased in hemophagocytic lymphohistiocytosis, enzyme expression is decreased following immunosuppressive therapy	Homo sapiens	-
T-lymphocyte	elevated granzyme B in cytotoxic T lymphocytes. The cells only express granzyme B following stimulation and differentiation into cytotoxic T lymphocytes. CD8 expressing GrB cells are increased in hemophagocytic lymphohistiocytosis, regardless of genetic etiology	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GrB	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	enzyme expression is decreased in natural killer cells following immunosuppressive therapy	down

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)