Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activation of CD4+ T cells with anti-CD3 and anti-CD28 or anti-CD46 induces granzyme B expression in all cells. Granzyme B expression in anti-CD3/anti-CD46 activated CD4+ T cells is much higher than granzyme B expression induced by usual activation (anti-CD3/anti-CD28) | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | granzyme B may be the limiting factor in adaptive regulatory T cell-mediated K562 target cell killing | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EGTA | - |
Homo sapiens | |
interleukin-4 | significantly suppresses granzyme B synthesis. Interleukin-4-mediated suppression of granzyme B leads to impaired cytotoxicity of adaptive regulatory T cells against K562 target cells | Homo sapiens | |
z-AAD-chloromethylketone | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | CD4+ adaptive regulatory T cells generated by co-ligation of CD3 and CD46 express high amounts of granzyme B | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GrB | - |
Homo sapiens |