Literature summary for 3.4.21.79 extracted from

Cao, X.; Cai, S.F.; Fehniger, T.A.; Song, J.; Collins, L.I.; Piwnica-Worms, D.R.; Ley, T.J.
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance (2007), Immunity, 27, 635-646.

Search for more literature for 3.4.21.79

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	granzyme B expression in Treg cells is activated by syngeneic tumor cell line	Mus musculus

Application

Application	Comment	Organism
medicine	Treg cells derived from the tumor environment can induce NK and CD8(+) T cell death in a granzyme B- and perforin-dependent fashion. Granzyme B and perforin are relevant for Treg cell-mediated suppression of tumor clearance in vivo	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	granzyme A/B-deficient mice exhibit significantly reduced survival compared to wild-type mice. Granzyme B-deficient mice clear both allogeneic and syngeneic tumor cell lines more efficiently than do wild-type mice. NK and CD8+ T cell death in tumor ascites of granzyme B-deficient mice is reduced after Treg cell depletion	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	129/SvJ mice	-
Mus musculus 129/SvJ	-	129/SvJ mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	granzyme B is not expressed in naive Treg cells but is highly expressed in 5%-30% of CD4(+)Foxp3(+) Treg cells in the tumor environment	Mus musculus	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)