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Literature summary for 3.4.21.79 extracted from

  • Shi, L.; Yang, X.; Froelich, C.J.; Greenberg, A.H.
    Purification and use of granzyme B (2000), Methods Enzymol., 322, 125-143.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of active GrB in yeast and by baculovirus expression Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ac-Ile-Glu-Thr-Asp-CHO specific granzyme B oligopeptide inhibitor Homo sapiens
Ac-Ile-Glu-Thr-Asp-CHO specific granzyme B oligopeptide inhibitor Mus musculus
Ac-Ile-Glu-Thr-Asp-CHO specific granzyme B oligopeptide inhibitor Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm cytoplasmic granules of cytotoxic T lymphocytes anf natural killer cells Mus musculus 5737
-
cytoplasm cytoplasmic granules of cytotoxic T lymphocytes anf natural killer cells Homo sapiens 5737
-
cytoplasm cytoplasmic granules of cytotoxic T lymphocytes anf natural killer cells Rattus norvegicus 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000 29000
-
Mus musculus
27000 32000
-
Homo sapiens
32000 34000
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus involved in cell killing by cytotoxic T lymphocytes, activates the apoptotic death pathway in the target cell ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human, YT cells, autonomously proliferating NK line, devoid of granzyme A and K
-
Mus musculus
-
mouse
-
Rattus norvegicus
-
rat, strain F344
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus
-
Rattus norvegicus
recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Boc-Ala-Ala-Asp-SBzl + H2O
-
Mus musculus ?
-
?
Boc-Ala-Ala-Asp-SBzl + H2O
-
Homo sapiens ?
-
?
Boc-Ala-Ala-Asp-SBzl + H2O
-
Rattus norvegicus ?
-
?
additional information involved in cell killing by cytotoxic T lymphocytes, activates the apoptotic death pathway in the target cell Mus musculus ?
-
?
additional information involved in cell killing by cytotoxic T lymphocytes, activates the apoptotic death pathway in the target cell Rattus norvegicus ?
-
?
additional information not able to induce apoptosis on its own Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
GrB
-
Homo sapiens
GrB
-
Rattus norvegicus