Cloned (Comment) | Organism |
---|---|
expression of active GrB in yeast and by baculovirus expression | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ac-Ile-Glu-Thr-Asp-CHO | specific granzyme B oligopeptide inhibitor | Homo sapiens | |
Ac-Ile-Glu-Thr-Asp-CHO | specific granzyme B oligopeptide inhibitor | Mus musculus | |
Ac-Ile-Glu-Thr-Asp-CHO | specific granzyme B oligopeptide inhibitor | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | cytoplasmic granules of cytotoxic T lymphocytes anf natural killer cells | Mus musculus | 5737 | - |
cytoplasm | cytoplasmic granules of cytotoxic T lymphocytes anf natural killer cells | Homo sapiens | 5737 | - |
cytoplasm | cytoplasmic granules of cytotoxic T lymphocytes anf natural killer cells | Rattus norvegicus | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
27000 | 29000 | - |
Mus musculus |
27000 | 32000 | - |
Homo sapiens |
32000 | 34000 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | involved in cell killing by cytotoxic T lymphocytes, activates the apoptotic death pathway in the target cell | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human, YT cells, autonomously proliferating NK line, devoid of granzyme A and K | - |
Mus musculus | - |
mouse | - |
Rattus norvegicus | - |
rat, strain F344 | - |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
- |
Rattus norvegicus |
recombinant enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Boc-Ala-Ala-Asp-SBzl + H2O | - |
Mus musculus | ? | - |
? | |
Boc-Ala-Ala-Asp-SBzl + H2O | - |
Homo sapiens | ? | - |
? | |
Boc-Ala-Ala-Asp-SBzl + H2O | - |
Rattus norvegicus | ? | - |
? | |
additional information | involved in cell killing by cytotoxic T lymphocytes, activates the apoptotic death pathway in the target cell | Mus musculus | ? | - |
? | |
additional information | involved in cell killing by cytotoxic T lymphocytes, activates the apoptotic death pathway in the target cell | Rattus norvegicus | ? | - |
? | |
additional information | not able to induce apoptosis on its own | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GrB | - |
Homo sapiens |
GrB | - |
Rattus norvegicus |