Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
regulatory T-lymphocyte | regulatory T cells (Tregs) freshly isolated from the peripheral blood of normal adults lack granzyme B expression. Tregs subjected to prolonged TCR and CD28 triggering, in the presence of IL-2, express high levels of granzyme B but CD3 stimulation alone or IL-2 treatment alone fail to induce granzyme B. Treatment of Tregs with the mammalian target of rapamycin (mTOR) inhibitor, rapamycin or the PI3 kinase (PI3K) inhibitor LY294002 markedly suppressed granzyme B expression | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
granzyme B | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | treatment of regulatory T cells (Tregs) with the mammalian target of rapamycin (mTOR) inhibitor, rapamycin or the PI3 kinase (PI3K) inhibitor LY294002 markedly suppresses granzyme B expression | down |
Homo sapiens | regulatory T cells (Tregs) freshly isolated from the peripheral blood of normal adults lack granzyme B expression. Tregs subjected to prolonged TCR and CD28 triggering, in the presence of IL-2, express high levels of granzyme B but CD3 stimulation alone or IL-2 treatment alone fail to induce granzyme B | up |
General Information | Comment | Organism |
---|---|---|
physiological function | TCR/CD28 mediated activation of the PI3K-mTOR pathway is important for granyzme B expression but not proliferation in regulatory T cells | Homo sapiens |