Literature summary for 3.4.21.79 extracted from

Pardo, J.; Wallich, R.; Ebnet, K.; Iden, S.; Zentgraf, H.; Martin, P.; Ekiciler, A.; Prins, A.; Muellbacher, A.; Huber, M.; Simon, M.M.
Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin (2007), Cell Death Differ., 14, 1768-1779.

Search for more literature for 3.4.21.79

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	secreted after Fcepsilon-receptor-mediated activation in cytoplasmic granules of bone marrow-derived mast cells	Mus musculus

Application

Application	Comment	Organism
medicine	activated mast cells contribute, via secreted gzmB, to cell death, increased vascular permeability, leukocyte extravasation and subsequent inflammatory processes in affected tissues. GzmB-induced detachment of adherent mouse embryonic fibroblasts leads to anoikis. GzmB induces a disorganization of endothelial cell-cell contacts	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	gzmB-deficient mice do not cause cell death in susceptible adherent target cells	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	is associated with cytoplasmic granules of bone marrow-derived mast cells	Mus musculus	5737	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
30000	-	Western blot analysis	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mast cell	skin-, but not lung-associated primary mast cells as well as in vitro-differentiated bone marrow-derived mast cells express GzmB	Mus musculus	-
skin	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-Ile-Glu-Pro-Asp-p-nitroanilide + H2O	-	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
GzmB	-	Mus musculus

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Release 2023.1 (January 2023)