Reference on EC 3.4.21.68 - t-Plasminogen activator
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Loskutoff, D.J.; Schleef, R.R.
Plasminogen activators and their inhibitors
Methods Enzymol.
163
293-302
1988
Homo sapiens
Saksela, O.; Rifkin, D.B.
Cell-associated plasminogen activation: regulation and physiological functions
Annu. Rev. Cell Biol.
4
93-126
1988
Homo sapiens
Verheijen, J.H.
Tissue-type plasminogen activator and fast-acting plasminogen activator inhibitor in plasma
Methods Enzymol.
163
302-309
1988
Homo sapiens
Gerard, R.D.; Meidell, R.S.
Regulation of tissue plasminogen activator expression
Annu. Rev. Physiol.
51
245-262
1989
Homo sapiens
Petersen, L.C.; Johannessen, M.; Foster, D.; Kumar, A.; Mulvihill, E.
The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage
Biochim. Biophys. Acta
952
245-254
1988
Homo sapiens
Pennica, D.; Holmes, W.E.; Kohr, W.J.; Harkins, R.N.; Vehar, G.A.; Ward, C.A.; Bennett, W.F.; Yelverton, E.; Seeburg, P.H.; Heyneker, H.L.; Goeddel, D.V.; Collen, D.
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli
Nature
301
214-221
1983
Homo sapiens
Saksela, O.
Plasminogen activation and regulation of pericellular proteolysis
Biochim. Biophys. Acta
823
35-65
1985
Homo sapiens
Margossian, S.S.; Slayter, H.S.; Kaczmarek, E.; McDonagh, J.
Physical characterization of recombinant tissue plasminogen activator
Biochim. Biophys. Acta
1163
250-256
1993
Homo sapiens
Liu, J.N.; Gurewich, V.
Substrate inhibition of fibrin-dependent plasminogen activation by tissue-type plasminogen activator
J. Biol. Chem.
268
12257-12259
1993
Homo sapiens
Lomas, D.A.; Evans, D.L.; Upton, C.; McFadden, G.; Carrell, R.W.
Inhibition of plasmin, urokinase, tissue plasminogen activator, and C1S by a myxoma virus serine proteinase inhibitor
J. Biol. Chem.
268
516-521
1993
Homo sapiens
Sherman, P.M.; Lawrence, D.A.; Verhamme, I.M.; Paielli, D.; Shore, J.D.; Ginsburg, D.
Identification of tissue-type plasminogen activator-specific plasminogen activator inhibitor-1 mutants. Evidence that second sites of interaction contribute to target specificity
J. Biol. Chem.
270
9301-9306
1995
Homo sapiens
Madison, E.L.; Coombs, G.S.; Corey, D.R.
Substrate specificity of tissue type plasminogen activator. Characterization of the fibrin independent specificity of t-PA for plasminogen
J. Biol. Chem.
270
7558-7562
1995
Homo sapiens
Rudd, P.M.; Woods, R.J.; Wormald, M.R.; Opdenakker, G.; Downing, A.K.; Campbell, I.D.; Dwek, R.A.
The effects of variable glycosylation on the functional activities of ribonuclease, plasminogen and tissue plasminogen activator
Biochim. Biophys. Acta
1248
1-10
1985
Mammalia
DeSerrano, V.S.; Menhart, N.; Castellino, F.J.
Expression, purification, and characterization of the recombinant kringle 1 domain from tissue-type plasminogen activator
Arch. Biochem. Biophys.
294
282-290
1992
Homo sapiens
Hu, C.K.; Kohnert, U.; Wilhelm, O.; Fischer, S.; Llinas, M.
Tissue-type plasminogen activator domain-deletion mutant BM 06.022: modular stability, inhibitor binding, and activation cleavage
Biochemistry
33
11760-11766
1994
Homo sapiens
Bos, R.; Berger, L.; Nieuenhuizen, W.
One-step purification of tissue-type plasminogen activator using affinity chromatography with a special monoclonal antibody under mild conditions
Biochim. Biophys. Acta
1117
188-192
1992
Homo sapiens
Urano, T.; Strandberg, L.; Johansson, L.B.A.; Ny, T.
A substrate-like form of plasminogen-activator-inhibitor type 1. Conversions between different forms by sodium dodecyl sulphate
Eur. J. Biochem.
209
985-992
1992
Escherichia coli
Lamba, D.; Bauer, M.; Huber, R.; Fischer, S.; Rudolph, R.; Kohnert, U.; Bode, W.
The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator
J. Mol. Biol.
258
117-135
1996
Homo sapiens (P00750), Homo sapiens
Hu, C.K.; Kohnert, U.; Sturzebecher, J.; Fischer, S.; Llinas, M.
Complexation of the tissue plasminogen activator protease with benzamidine-type inhibitors: interference by the kringle 2 module
Biochemistry
35
3270-3276
1996
Homo sapiens
Declerck, P.J.; De Mol, M.; Vaughan, D.E.; Collen, D.
Identification of a conformationally distinct form of plasminogen activator inhibitor-1, acting as a noninhibitory substrate for tissue-type plasminogen activator
J. Biol. Chem.
267
11693-11696
1992
Homo sapiens
Kaneko, M.; Sakata, Y.; Matsuda, M.; Mimuro, J.
Interactions between the finger and kringle-2 domains of tissue-type plasminogen activator and plasminogen activator inhibitor-1
J. Biochem.
111
244-248
1992
Homo sapiens
Denman, J.; Hayes, M.; O'Day, C.; Edmunds, T.; Bartlett, C.; Hirani, S.; Ebert, K.M.; Gordon, K.; McPherson, J.M.
Transgenic expression of a variant of human tissue-type plasminogen activator in goat milk: purification and characterization of the recombinant enzyme
Biotechnology (N.Y.)
9
839-843
1991
Homo sapiens
Itagaki, Y.; Yasuda, H.; Morinaga, T.; Mitsuda, S.; Higashio, K.
Purification and characterization of tissue plasminogen activator secreted by human embryonic lung diploid fibroblasts, IMR-90 cells [published erratum appears in Agric Biol Chem 1991 Jun;55(6):A10]
Agric. Biol. Chem.
55
1225-1232
1991
Homo sapiens
Hofmann, K.J.; Mayer, E.J.; Schultz, L.D.; Socher, S.H.; Reilley, C.F.
Purification and characterization of recombinant rabbit plasminogen activator inhibitor-1 expressed in Saccharomyces cerevisiae
Fibrinolysis
6
263-272
1992
Homo sapiens
-
Lijnen, H.R.; Webb, P.D.; van Hoef, B.; De Cock, F.; Stassen, J.M.; Prior, S.D.; Collen, D.
Biochemical and biological properties of a recombinant tissue-type plasminogen activator derived from the rat JMI-229 cell line
Thromb. Haemost.
67
239-247
1992
Rattus norvegicus
Nulkar, M.W.; Darad, R.; Subramanian, M.; Pawse, A.R.
Plasminogen activator: isolation and purification from lymphosarcoma of ascites bearing mice
J. Biosci.
16
223-233
1991
Mus musculus
-
Mikus, P.; Urano, T.; Liljestrm, P.; Ny, T.
Plasminogen-activator inhibitor type 2 (PAI-2) is a spontaneously polymerising SERPIN. Biochemical characterisation of the recombinant intracellular and extracellular forms
Eur. J. Biochem.
218
1071-1082
1993
Mammalia
Hua, Z.C.
Renaturation and purification of recombinant tissue-type plasminogen activator expressed in E. coli
Biochem. Mol. Biol. Int.
41
815-820
1997
Homo sapiens
Butenas, S.; Kalafatis, M.; Mann, K.G.
Analysis of tissue plasminogen activator specificity using peptidyl fluorogenic substrates
Biochemistry
36
2123-2131
1997
Homo sapiens
Chang, Y.; Zajicek, J.; Castellino, F.J.
Role of tryptophan-63 of the kringle 2 domain of tissue-type plasminogen activator in its thermal stability, folding, and ligand binding properties
Biochemistry
36
7652-7663
1997
Homo sapiens
Johnsen, L.B.; Ravn, P.; Berglund, L.; Petersen, T.E.; Rasmussen, L.K.; Heegaard, C.W.; Rasmussen, J.T.; Benfeldt, C.; Fedosov, S.N.
A refined kinetic analysis of plasminogen activation by recombinant bovine tissue-type plasminogen activator indicates two interconvertible activator forms
Biochemistry
37
12631-12639
1998
Bos taurus, Homo sapiens
Grundy, J.E.; Lavigne, N.; Hirama, T.; MacKenzie, C.R.; Pryzdial, E.L.
Binding of plasminogen and tissue plasminogen activator to plasmin-modulated factor X and factor Xa
Biochemistry
40
6293-6302
2001
Homo sapiens
Bode, W.; Renatus, M.
Tissue-type plasminogen activator: variants and crystal/solution structures demarcate structural determinants of function
Curr. Opin. Struct. Biol.
7
865-872
1997
Homo sapiens
Ke, S.H.; Tachias, K.; Lamba, D.; Bode, W.; Madison, E.L.
Identification of a hydrophobic exosite on tissue type plasminogen activator that modulates specificity for plasminogen
J. Biol. Chem.
272
1811-1816
1997
Homo sapiens
Renatus, M.; Bode, W.; Huber, R.; Sturzebecher, J.; Prasa, D.; Fischer, S.; Kohnert, U.; Stubbs, M.T.
Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors
J. Biol. Chem.
272
21713-21719
1997
Homo sapiens
Coombs, G.S.; Bergstrom, R.C.; Madison, E.L.; Corey, D.R.
Directing sequence-specific proteolysis to new targets. The influence of loop size and target sequence on selective proteolysis by tissue-type plasminogen activator and urokinase-type plasminogen activator
J. Biol. Chem.
273
4323-4328
1998
Homo sapiens
Sinniger, V.; Merton, R.E.; Fabregas, P.; Felez, J.; Longstaff, C.
Regulation of tissue plasminogen activator activity by cells. Domains responsible for binding and mechanism of stimulation
J. Biol. Chem.
274
12414-12422
1999
Homo sapiens
Shim, B.S.; Kang, B.H.; Hong, Y.K.; Kim, H.K.; Lee, I.H.; Lee, S.Y.; Lee, Y.J.; Lee, S.K.; Joe, Y.A.
The kringle domain of tissue-type plasminogen activator inhibits in vivo tumor growth
Biochem. Biophys. Res. Commun.
327
1155-1162
2005
Homo sapiens (P00750), Homo sapiens
Rolland, Y.; Demeule, M.; Beliveau, R.
Melanotransferrin stimulates t-PA-dependent activation of plasminogen in endothelial cells leading to cell detachment
Biochim. Biophys. Acta
1763
393-401
2006
Homo sapiens (P00750), Homo sapiens
Fredriksson, L.; Li, H.; Fieber, C.; Li, X.; Eriksson, U.
Tissue plasminogen activator is a potent activator of PDGF-CC
EMBO J.
23
3793-3802
2004
Mus musculus (P11214), Mus musculus
Medina, M.G.; Ledesma, M.D.; Dominguez, J.E.; Medina, M.; Zafra, D.; Alameda, F.; Dotti, C.G.; Navarro, P.
Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation
EMBO J.
24
1706-1716
2005
Mus musculus (P11214), Rattus norvegicus (P19637)
Diaz, V.M.; Hurtado, M.; Thomson, T.M.; Reventos, J.; Paciucci, R.
Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer cells activates plasminogen and promotes invasion in vitro
Gut
53
993-1000
2004
Homo sapiens (P00750)
Komissarov, A.A.; Declerck, P.J.; Shore, J.D.
Protonation State of a Single Histidine Residue Contributes Significantly to the Kinetics of the Reaction of Plasminogen Activator Inhibitor-1 with Tissue-type Plasminogen Activator
J. Biol. Chem.
279
23007-23013
2004
Homo sapiens (P00750), Homo sapiens
Hu, K.; Yang, J.; Tanaka, S.; Gonias, S.L.; Mars, W.M.; Liu, Y.
Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression
J. Biol. Chem.
281
2120-2127
2006
Mus musculus (P11214), Mus musculus, Rattus norvegicus (P19637)
Ohnishi, J.; Yokota, J.; Rajapakse, R.G.S.C.; Ohnishi, E.; Kudo, T.; Wada, S.i.; Takahashi, T.
Activity of an enzyme converting single-chain tissue-type plasminogen activator to the two-chain form in preovulatory human follicular fluid
Mol. Reprod. Dev.
67
178-185
2004
Homo sapiens (P00750), Homo sapiens
Lee, S.B.; Oh, H.K.; Kim, H.K.; Joe, Y.A.
Expression of the non-glycosylated kringle domain of tissue type plasminogen activator in Pichia and its anti-endothelial cell activity
Protein Expr. Purif.
50
1-8
2006
Komagataella pastoris
Wu, F.; Yu, J.; Li, R.
Novel biomimetic affinity ligands for human tissue plasminogen activator
Biochem. Biophys. Res. Commun.
355
673-678
2007
Homo sapiens (P00750), Homo sapiens
Liu, H.; Zhou, X.; Zhang, Y.
A comparative investigation on different refolding strategies of recombinant human tissue-type plasminogen activator derivative
Biotechnol. Lett.
28
457-463
2006
Homo sapiens
Flight, S.M.; Masci, P.P.; Lavin, M.F.; Gaffney, P.J.
Resistance of porcine blood clots to lysis relates to poor activation of porcine plasminogen by tissue plasminogen activator
Blood Coagul. Fibrinolysis
17
417-420
2006
Sus scrofa
Komoriya, K.; Kato, Y.; Hayashi, Y.; Ohsuye, K.; Nishigaki, R.; Sugiyama, Y.
Characterization of the hepatic disposition of lanoteplase, a rationally designed variant of tissue plasminogen activator in rodents
Drug Metab. Dispos.
35
469-475
2007
Rattus norvegicus
Lund, L.R.; Green, K.A.; Stoop, A.A.; Ploug, M.; Almholt, K.; Lilla, J.; Nielsen, B.S.; Christensen, I.J.; Craik, C.S.; Werb, Z.; Dan?, K.; R?mer, J.
Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice
EMBO J.
25
2686-2697
2006
Mus musculus
Hurtado, M.; Lozano, J.J.; Castellanos, E.; Lopez-Fernandez, L.A.; Harshman, K.; Martinez-A, C.; Ortiz, A.R.; Thomson, T.M.; Paciucci, R.
Activation of the epidermal growth factor signalling pathway by tissue plasminogen activator in pancreas cancer cells
Gut
56
1266-1274
2007
Homo sapiens
Susarla, R.; Watkinson, J.C.; Eggo, M.C.
Regulation of plasminogen activators in human thyroid follicular cells and their relationship to differentiated function
J. Cell. Physiol.
212
643-654
2007
Homo sapiens
Ismail, B.; Choi, L.H.; Were, L.M.; Nielsen, S.S.
Activity and nature of plasminogen activators associated with the casein micelle
J. Dairy Sci.
89
3285-3295
2006
Bos taurus
Zou, T.; Ling, C.; Xiao, Y.; Tao, X.; Ma, D.; Chen, Z.L.; Strickland, S.; Song, H.
Exogenous tissue plasminogen activator enhances peripheral nerve regeneration and functional recovery after injury in mice
J. Neuropathol. Exp. Neurol.
65
78-86
2006
Mus musculus
Gurewich, V.; Pannell, R.; Simmons-Byrd, A.; Sarmientos, P.; Liu, J.N.; Badylak, S.F.
Thrombolysis vs. bleeding from hemostatic sites by a prourokinase mutant compared with tissue plasminogen activator
J. Thromb. Haemost.
4
1559-1565
2006
Canis lupus familiaris
Thelwell, C.; Longstaff, C.
The regulation by fibrinogen and fibrin of tissue plasminogen activator kinetics and inhibition by plasminogen activator inhibitor 1
J. Thromb. Haemost.
5
804-811
2007
Homo sapiens
Cacquevel, M.; Launay, S.; Castel, H.; Benchenane, K.; Cheenne, S.; Buee, L.; Moons, L.; Delacourte, A.; Carmeliet, P.; Vivien, D.
Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms
Neurobiol. Dis.
27
164-173
2007
Homo sapiens, Mus musculus
Gunes, A.M.; Bostan, O.M.; Baytan, B.; Semizel, E.
Treatment of infective endocarditis with recombinant tissue plasminogen activator
Pediatr. Blood Cancer
50
132-134
2008
Homo sapiens
Wilczak, N.; Elting, J.W.; Chesik, D.; Kema, I.P.; De Keyser, J.
Intravenous tissue plasminogen activator in patients with stroke increases the bioavailability of insulin-like growth factor-1
Stroke
37
2368-2371
2006
Homo sapiens
He, S.; Zhu, K.; Skeppholm, M.; Vedin, J.; Svensson, J.; Egberg, N.; Blombaeck, M.; Wallen, H.
A global assay of haemostasis which uses recombinant tissue factor and tissue-type plasminogen activator to measure the rate of fibrin formation and fibrin degradation in plasma
Thromb. Haemost.
98
871-882
2007
Homo sapiens
Davis-Jackson, R.; Correa, H.; Horswell, R.; Sadowska-Krowicka, H.; McDonough, K.; Debata, C.; Gardner, R.; Penn, D.
Antithrombin III (AT) and recombinant tissue plasminogen activator (R-TPA) used singly and in combination versus supportive care for treatment of endotoxin-induced disseminated intravascular coagulation (DIC) in the neonatal pig
Thromb. J.
4
7
2006
Sus scrofa
Sun, H.Y.; Szlam, F.; Levy, J.H.; Csete, M.E.; Tanaka, K.A.
Antifibrinolytic agents reduce tissue plasminogen activator-mediated neuronal toxicity in vitro
Acta Anaesthesiol. Scand.
53
325-331
2009
synthetic construct
Lian, X.; Yang, L.; Gao, Q.; Yang, T.
IL-1alpha is a potent stimulator of keratinocyte tissue plasminogen activator expression and regulated by TGF-beta1
Arch. Dermatol. Res.
300
185-193
2008
Mus musculus
Bu, C.; Gao, L.; Xie, W.; Zhang, J.; He, Y.; Cai, G.; McCrae, K.R.
beta2-glycoprotein i is a cofactor for tissue plasminogen activator-mediated plasminogen activation
Arthritis Rheum.
60
559-568
2009
Homo sapiens
Ma, Y.H.; Wu, S.Y.; Wu, T.; Chang, Y.J.; Hua, M.Y.; Chen, J.P.
Magnetically targeted thrombolysis with recombinant tissue plasminogen activator bound to polyacrylic acid-coated nanoparticles
Biomaterials
30
3343-3351
2009
synthetic construct
Suzuki, Y.; Mogami, H.; Ihara, H.; Urano, T.
Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells
Blood
113
470-478
2009
Homo sapiens
Wiegler, K.; Bonny, C.; Coquoz, D.; Hirt, L.
The JNK inhibitor XG-102 protects from ischemic damage with delayed intravenous administration also in the presence of recombinant tissue plasminogen activator
Cerebrovasc. Dis.
26
360-366
2008
Homo sapiens
Lou, M.; Selim, M.
Does body weight influence the response to intravenous tissue plasminogen activator in stroke patients?
Cerebrovasc. Dis.
27
84-90
2009
Homo sapiens
Kardesler, L.; Buduneli, N.; Biyikoglu, B.; Cetinkalp, S.; Kuetuekcueler, N.
Gingival crevicular fluid PGE2, IL-1beta, t-PA, PAI-2 levels in type 2 diabetes and relationship with periodontal disease
Clin. Biochem.
41
863-868
2008
Homo sapiens
Hertzberg, V.; Ingall, T.; O'Fallon, W.; Asplund, K.; Goldfrank, L.; Louis, T.; Christianson, T.
Methods and processes for the reanalysis of the NINDS tissue plasminogen activator for acute ischemic stroke treatment trial
Clin. Trials
5
308-315
2008
Homo sapiens
Adibhatla, R.M.; Hatcher, J.F.
Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies
CNS Neurol. Disord. Drug Targets
7
243-253
2008
Homo sapiens, Mus musculus, Rattus norvegicus, Desmodus rotundus
Giannarelli, C.; Virdis, A.; De Negri, F.; Duranti, E.; Magagna, A.; Ghiadoni, L.; Salvetti, A.; Taddei, S.
Tissue-type plasminogen activator release in healthy subjects and hypertensive patients: relationship with beta-adrenergic receptors and the nitric oxide pathway
Hypertension
52
314-321
2008
Homo sapiens
Hu, K.; Lin, L.; Tan, X.; Yang, J.; Bu, G.; Mars, W.M.; Liu, Y.
tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis
J. Am. Soc. Nephrol.
19
503-514
2008
Homo sapiens, Mus musculus
Heil, J.W.; Malinowski, L.; Rinderknecht, A.; Broderick, J.P.; Franz, D.
Use of intravenous tissue plasminogen activator in a 16-year-old patient with basilar occlusion
J. Child Neurol.
23
1049-1053
2008
Homo sapiens
Cuadrado, E.; Ortega, L.; Hernandez-Guillamon, M.; Penalba, A.; Fernandez-Cadenas, I.; Rosell, A.; Montaner, J.
Tissue plasminogen activator (t-PA) promotes neutrophil degranulation and MMP-9 release
J. Leukoc. Biol.
84
207-214
2008
synthetic construct
Robb, A.O.; Mills, N.L.; Din, J.N.; Cameron, S.; Ludlam, C.A.; Newby, D.E.; Denison, F.C.
Acute endothelial tissue plasminogen activator release in pregnancy
J. Thromb. Haemost.
7
138-142
2009
Homo sapiens
Luo, M.; Tao, P.; Li, J.; Zhou, S.; Guo, D.; Pan, Z.
Immunization with plasmid DNA encoding influenza A virus nucleoprotein fused to a tissue plasminogen activator signal sequence elicits strong immune responses and protection against H5N1 challenge in mice
J. Virol. Methods
154
121-127
2008
synthetic construct
Hou, S.J.; Yen, F.C.; Tsai, S.J.
Is dysfunction of the tissue plasminogen activator (tPA)-plasmin pathway a link between major depression and cardiovascular disease?
Med. Hypotheses
72
166-168
2009
Homo sapiens, Mus musculus
Onder, A.M.; Chandar, J.; Simon, N.; Diaz, R.; Nwobi, O.; Abitbol, C.L.; Zilleruelo, G.
Comparison of tissue plasminogen activator-antibiotic locks with heparin-antibiotic locks in children with catheter-related bacteraemia
Nephrol. Dial. Transplant.
23
2604-2610
2008
synthetic construct
Lee, S.Y.; Kim, H.J.; Lee, W.J.; Joo, S.H.; Jeon, S.J.; Kim, J.W.; Kim, H.S.; Han, S.H.; Lee, J.; Park, S.H.; Cheong, J.H.; Kim, W.K.; Ko, K.H.; Shin, C.Y.
Differential regulation of matrix metalloproteinase-9 and tissue plasminogen activator activity by the cyclic-AMP system in lipopolysaccharide-stimulated rat primary astrocytes
Neurochem. Res.
33
2324-2334
2008
Rattus norvegicus
Cekinmez, M.; Erdogan, B.; Tufan, K.; Sarica, F.B.; Ozen, O.; Caner, H.
Is topical tissue plasminogen activator application effective on prevention of post-laminectomy epidural fibrosis? An experimental study
Neurol. Res.
31
322-326
2008
synthetic construct
Lobov, S.; Croucher, D.R.; Saunders, D.N.; Ranson, M.
Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro: potential receptor interactions
Thromb. Haemost.
100
319-329
2008
synthetic construct
Marder, V.J.
Pre-clinical studies of plasmin: superior benefit-to-risk ratio of plasmin compared to tissue plasminogen activator
Thromb. Res.
122 Suppl 3
S9-S15
2008
Oryctolagus cuniculus, Homo sapiens
McBane, R.D.; Hardison, R.M.; Sobel, B.E.; Sobel, B.E.
Comparison of plasminogen activator inhibitor-1, tissue type plasminogen activator antigen, fibrinogen, and D-dimer levels in various age decades in patients with type 2 diabetes mellitus and stable coronary artery disease (from the BARI 2D trial)
Am. J. Cardiol.
105
17-24
2010
Homo sapiens
Borisov, O.V.; Field, M.; Ling, V.T.; Harris, R.J.
Characterization of oligosaccharides in recombinant tissue plasminogen activator produced in Chinese hamster ovary cells: two decades of analytical technology development
Anal. Chem.
81
9744-9754
2009
Homo sapiens
Pothakos, K.; Robinson, J.K.; Gravanis, I.; Marsteller, D.A.; Dewey, S.L.; Tsirka, S.E.
Decreased serotonin levels associated with behavioral disinhibition in tissue plasminogen activator deficient (tPA-/-) mice
Brain Res.
1326
135-142
2010
Mus musculus
Lapchak, P.A.; Han, M.K.
Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor, but not the thrombolytic tissue plasminogen activator
Brain Res.
1344
217-225
2010
Oryctolagus cuniculus
Hu, X.Y.; Ma, Y.H.; Wang, C.; Yang, Y.H.
Effects of simvastatin on cigarette smoke extract induced tissue-type plasminogen activator and plasminogen activator inhibitor-1 expression in human umbilical vein endothelial cells
Chin. Med. Sci.
122
2380-2385
2009
Homo sapiens
David, H.N.; Haelewyn, B.; Risso, J.J.; Colloch, N.; Abraini, J.H.
Xenon is an inhibitor of tissue-plasminogen activator: adverse and beneficial effects in a rat model of thromboembolic stroke
J. Cereb. Blood Flow Metab.
30
718-728
2010
Rattus norvegicus, Homo sapiens (P00750), Homo sapiens
Woernle, M.; Roeder, M.; Sauter, M.; Merkle, M.; Ribeiro, A.
Effect of dsRNA on mesangial cell synthesis of plasminogen activator inhibitor type 1 and tissue plasminogen activator
Nephron Exp. Nephrol.
113
57-65
2009
Homo sapiens (P00750), Homo sapiens
Hultman, K.; Bjoerklund, U.; Hansson, E.; Jern, C.
Potentiating effect of endothelial cells on astrocytic plasminogen activator inhibitor type-1 gene expression in an in vitro model of the blood-brain barrier
Neuroscience
166
408-415
2010
Rattus norvegicus
Iyer, A.M.; Zurolo, E.; Boer, K.; Baayen, J.C.; Giangaspero, F.; Arcella, A.; Di Gennaro, G.C.; Esposito, V.; Spliet, W.G.; van Rijen, P.C.; Troost, D.; Gorter, J.A.; Aronica, E.
Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies
Neuroscience
167
929-945
2010
Homo sapiens
Kim, S.; von Recum, H.A.
Endothelial progenitor populations in differentiating embryonic stem cells. II. Drug selection and functional characterization
Tissue Eng. Part A
16
1065-1074
2010
Mus musculus
Majidzadeh-A, K.; Khalaj, V.; Fatemeh, D.; Mahdi, H.; Farzaneh, B.; Ahmad, A.; Mahboudi, F.
Cloning and expression of functional full-length human tissue plasminogen activator in Pichia pastoris
Appl. Biochem. Biotechnol.
162
2037-2048
2010
Homo sapiens
Geng, Y.; Wang, S.; Qi, Q.
Expression of active recombinant human tissue-type plasminogen activator by using in vivo polyhydroxybutyrate granule display
Appl. Environ. Microbiol.
76
7226-7230
2010
Homo sapiens
Kim, H.; Joe, Y.
DGDA, a local sequence of the kringle 2 domain, is a functional motif of the tissue-type plasminogen activators antiangiogenic kringle domain
Biochem. Biophys. Res. Commun.
391
166-169
2010
Homo sapiens
Su, L.; Xu, X.; Zhao, H.; Gu, Q.; Zou, H.
In vitro and in vivo antiangiogenic activity of a novel deca-peptide derived from human tissue-type plasminogen activator kringle 2
Biochem. Biophys. Res. Commun.
396
1012-1017
2010
Homo sapiens
Baron, A.; Hommet, Y.; Casse, F.; Vivien, D.
Tissue-type plasminogen activator induces plasmin-dependent proteolysis of intracellular neuronal nitric oxide synthase
Biol. Cell
102
539-547
2010
Mus musculus
Nazari, R.; Davoudi, N.
Cloning and expression of truncated form of tissue plasminogen activator in Leishmania tarentolae
Biotechnol. Lett.
33
503-508
2011
Homo sapiens
Ohki, M.; Ohki, Y.; Ishihara, M.; Nishida, C.; Tashiro, Y.; Akiyama, H.; Komiyama, H.; Lund, L.R.; Nitta, A.; Yamada, K.; Zhu, Z.; Ogawa, H.; Yagita, H.; Okumura, K.; Nakauchi, H.; Werb, Z.; Heissig, B.; Hattori, K.
Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration
Blood
115
4302-4312
2010
Mus musculus, Mus musculus C57BL/6
Longstaff, C.; Thelwell, C.; Williams, S.C.; Silva, M.M.; Szabo, L.; Kolev, K.
The interplay between tissue plasminogen activator domains and fibrin structures in the regulation of fibrinolysis: kinetic and microscopic studies
Blood
117
661-668
2011
Homo sapiens
Kaleri, H.A.; Xiang, L.; Aniwashi, J.; Xu, S.
Oviduct-specific expression of tissue plasminogen activator in laying hens
Genet. Mol. Biol.
34
231-236
2011
Homo sapiens
Zhang, H.; Bi, F.; Xiao, C.; Liu, J.; Wang, Z.; Liu, J.N.; Zhang, J.
The Kringle-2 domain of tissue plasminogen activator significantly reduces mortality and brain infarction in middle cerebral artery occlusion rats
Int. J. Mol. Med.
26
225-230
2010
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Correa, F.; Gauberti, M.; Parcq, J.; Macrez, R.; Hommet, Y.; Obiang, P.; Hernangomez, M.; Montagne, A.; Liot, G.; Guaza, C.; Maubert, E.; Ali, C.; Vivien, D.; Docagne, F.
Tissue plasminogen activator prevents white matter damage following stroke
J. Exp. Med.
208
1229-1242
2011
Homo sapiens, Mus musculus, Mus musculus C57/BL6
Sereda, M.J.; Bradding, P.; Vial, C.
Adenosine potentiates human lung mast cell tissue plasminogen activator activity
J. Immunol.
186
1209-1217
2011
Homo sapiens
Emmetsberger, J.; Mirrione, M.M.; Zhou, C.; Fernandez-Monreal, M.; Siddiq, M.M.; Ji, K.; Tsirka, S.E.
Tissue plasminogen activator alters intracellular sequestration of zinc through interaction with the transporter ZIP4
J. Neurosci.
30
6538-6547
2010
Mus musculus, Mus musculus C57BL/6
Sashindranath, M.; Samson, A.L.; Downes, C.E.; Crack, P.J.; Lawrence, A.J.; Li, Q.X.; Ng, A.Q.; Jones, N.C.; Farrugia, J.J.; Abdella, E.; Vassalli, J.D.; Madani, R.; Medcalf, R.L.
Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation
Lab. Invest.
91
1079-1091
2011
Mus musculus, Mus musculus C57/BL6J
Ahmed, W.; Malik, M.; Saeed, I.; Khan, A.A.; Sadeque, A.; Kaleem, U.; Ahmed, N.; Ajmal, M.; Azam, M.; Qamar, R.
Role of tissue plasminogen activator and plasminogen activator inhibitor polymorphism in myocardial infarction
Mol. Biol. Rep.
38
2541-2548
2011
Homo sapiens
Kim, J.W.; Lee, S.H.; Ko, H.M.; Kwon, K.J.; Cho, K.S.; Choi, C.S.; Park, J.H.; Kim, H.Y.; Lee, J.; Han, S.H.; Ignarro, L.J.; Cheong, J.H.; Kim, W.K.; Shin, C.Y.
Biphasic regulation of tissue plasminogen activator activity in ischemic rat brain and in cultured neural cells: Essential role of astrocyte-derived plasminogen activator inhibitor-1
Neurochem. Int.
58
423-433
2011
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Luo, X.G.; Tian, W.J.; Ni, M.; Jing, X.L.; Lv, L.H.; Wang, N.; Jiang, Y.; Zhang, T.C.
Soluble expression of active recombinant human tissue plasminogen activator derivative (K2S) in Escherichia coli
Pharm. Biol.
49
653-657
2011
Homo sapiens
Kang, S.; Ajjappala, H.; Seo, H.; Sim, J.; Yoon, S.; Koo, B.; Kim, Y.; Lee, S.; Hahn, B.
Expression of the human tissue-plasminogen activator in hairy roots of oriental melon (Cucumis melo)
Plant Mol. Biol. Rep.
29
919-926
2011
Homo sapiens, no activity in Cucumis melo
-
Xin, H.; Li, Y.; Shen, L.H.; Liu, X.; Wang, X
Zhang, J.; Pourabdollah-Nejad, S.; Zhang, C.; Zhang, L.; Jiang, H.; Zhang, Z.G.; Chopp, M.: Increasing tPA activity in astrocytes induced by multipotent mesenchymal stromal cells facilitate neurite outgrowth after stroke in the mouse
PLoS ONE
5
e9027
2010
Mus musculus
Schonfeld-Dado, E.; Segal, M.
Activity deprivation induces neuronal cell death: mediation by tissue-type plasminogen activator
PLoS ONE
6
e25919
2011
Rattus norvegicus
Nabiabad, H.S.; Yaghoobi, M.M.; Javaran, M.J.; Hosseinkhani, S.
Expression analysis and purification of human recombinant tissue type plasminogen activator (rt-PA) from transgenic tobacco plants
Prep. Biochem. Biotechnol.
41
175-186
2011
Homo sapiens
Noel, M.; Norris, E.H.; Strickland, S.
Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice
Proc. Natl. Acad. Sci. USA
108
5069-5074
2011
Mus musculus
Masoumiasl, A.; Jalali-Javaran, M.; Mahboudi, F.; Alizadeh, H.
Cloning and expression of tissue plasminogen activator (t-pa) gene in tobacco plants
Sci. Res. Essays
5
917-922
2010
Homo sapiens
-
Macrez, R.; Bezin, L.; Le Mauff, B.; Ali, C.; Vivien, D.
Functional occurrence of the interaction of tissue plasminogen activator with the NR1 subunit of N-methyl-D-aspartate receptors during stroke
Stroke
41
2950-2955
2010
Mus musculus, Mus musculus Swiss
Shen, L.H.; Xin, H.; Li, Y.; Zhang, R.L.; Cui, Y.; Zhang, L.; Lu, M.; Zhang, Z.G.; Chopp, M.
Endogenous tissue plasminogen activator mediates bone marrow stromal cell-induced neurite remodeling after stroke in mice
Stroke
42
459-464
2011
Mus musculus, Mus musculus C57BL/6
Venkatraj, M.; Messagie, J.; Joossens, J.; Lambeir, A.M.; Haemers, A.; Van der Veken, P.; Augustyns, K.
Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA)
Bioorg. Med. Chem.
20
1557-1568
2012
Homo sapiens (P00750)
Kazemali, M.; Majidzadeh-A, K.; Sardari, S.; Saadatirad, A.H.; Khalaj, V.; Zarei, N.; Barkhordari, F.; Adeli, A.; Mahboudi, F.
Design of a novel chimeric tissue plasminogen activator with favorable Vampire bat plasminogen activator properties
Enzyme Microb. Technol.
67
82-86
2014
Homo sapiens (P00750), Homo sapiens
Mahboudi, F.; Barkhordari, F.; Godarzi, R.M.; Enayati, S.; Davami, F.
A fed-batch based cultivation mode in Escherichia coli results in improved specific activity of a novel chimeric-truncated form of tissue plasminogen activator
J. Appl. Microbiol.
114
364-372
2013
Homo sapiens (P00750)
Ng, K.S.; Leung, H.W.; Wong, P.T.; Low, C.M.
Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate (NMDA) receptor by tissue plasminogen activator: identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor
J. Biol. Chem.
287
25520-25529
2012
Homo sapiens (P00750), Homo sapiens
Kim, S.; Sim, J.; Ajjappala, H.; Kim, Y.; Hahn, B.
Expression and large-scale production of the biochemically active human tissue-plasminogen activator in hairy roots of Oriental melon (Cucumis melo)
J. Biosci. Bioeng.
113
106-111
2012
Homo sapiens
Rahimpour, A.; Vaziri, B.; Moazzami, R.; Nematollahi, L.; Barkhordari, F.; Kokabee, L.; Adeli, A.; Mahboudi, F.
Engineering the cellular protein secretory pathway for enhancement of recombinant tissue plasminogen activator expression in Chinese hamster ovary cells: effects of CERT and XBP1s genes
J. Microbiol. Biotechnol.
23
1116-1122
2013
Homo sapiens (P00750)
Long, X.; Gou, Y.; Luo, M.; Zhang, S.; Zhang, H.; Bai, L.; Wu, S.; He, Q.; Chen, K.; Huang, A.; Zhou, J.; Wang, D.
Soluble expression, purification, and characterization of active recombinant human tissue plasminogen activator by auto-induction in E. coli
BMC Biotechnol.
15
13
2015
Homo sapiens (P00750), Homo sapiens
Li, C.Y.; de Veer, S.J.; Law, R.H.P.; Whisstock, J.C.; Craik, D.J.; Swedberg, J.E.
Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde library
ChemBioChem
20
46-50
2019
Homo sapiens (P00750)
Heid, S.; Unterweger, H.; Tietze, R.; Friedrich, R.; Weigel, B.; Cicha, I.; Eberbeck, D.; Boccaccini, A.; Alexiou, C.; Lyer, S.
Synthesis and characterization of tissue plasminogen activator - functionalized superparamagnetic iron oxide nanoparticles for targeted fibrin clot dissolution
Int. J. Mol. Sci.
18
E1837
2017
Homo sapiens (P00750), Homo sapiens
Gong, L.; Liu, M.; Zeng, T.; Shi, X.; Yuan, C.; Andreasen, P.A.; Huang, M.
Crystal structure of the Michaelis complex between tissue-type plasminogen activator and plasminogen activators inhibitor-1
J. Biol. Chem.
290
25795-25804
2015
Homo sapiens (P00750)
Ly, D.; Donahue, D.; Walker, M.J.; Ploplis, V.A.; McArthur, J.D.; Ranson, M.; Castellino, F.J.; Sanderson-Smith, M.L.
Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection
Microbes Infect.
21
412-417
2019
Mus musculus (P11214), Mus musculus
Abdoli Nasab, M.; Jalali Javaran, M.; Cusido, R.M.; Palazon, J.
Purification of recombinant tissue plasminogen activator (rtPA) protein from transplastomic tobacco plants
Plant Physiol. Biochem.
108
139-144
2016
Homo sapiens (P00750), Homo sapiens
Nabiabad, H.S.; Piri, K.; Amini, M.
Expression of active chimeric-tissue plasminogen activator in tobacco hairy roots, identification of a DNA aptamer and purification by aptamer functionalized-MWCNTs chromatography
Protein Expr. Purif.
152
137-145
2018
Homo sapiens (P00750), Homo sapiens
Garcia-Vazquez, F.A.; Soriano-Ubeda, C.; Laguna-Barraza, R.; Izquierdo-Rico, M.J.; Navarrete, F.A.; Visconti, P.E.; Gutierrez-Adan, A.; Coy, P.
Tissue plasminogen activator (tPA) of paternal origin is necessary for the success of in vitro but not of in vivo fertilisation in the mouse
Reprod. Fertil. Dev.
31
433-442
2019
Mus musculus (P11214), Mus musculus, Mus musculus CD-1 (P11214)
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