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Literature summary for 3.4.21.68 extracted from

  • Zou, T.; Ling, C.; Xiao, Y.; Tao, X.; Ma, D.; Chen, Z.L.; Strickland, S.; Song, H.
    Exogenous tissue plasminogen activator enhances peripheral nerve regeneration and functional recovery after injury in mice (2006), J. Neuropathol. Exp. Neurol., 65, 78-86.
    View publication on PubMed

Application

Application Comment Organism
medicine it is shown that exogenous tPA or tPA/plasminogen promotes axonal regeneration, remyelination, and functional recovery after sciatic nerve injury in the mouse, probably through removal of fibrin deposition and activation of MMP-9-positive macrophages, which may be responsible for myelin debris clearance and preventing collagen scar formation. Therefore, tPA may be useful for treatment of peripheral nerve injury Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
tPA
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Mus musculus