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Literature summary for 3.4.21.68 extracted from

  • Xin, H.; Li, Y.; Shen, L.H.; Liu, X.; Wang, X
    Zhang, J.; Pourabdollah-Nejad, S.; Zhang, C.; Zhang, L.; Jiang, H.; Zhang, Z.G.; Chopp, M.: Increasing tPA activity in astrocytes induced by multipotent mesenchymal stromal cells facilitate neurite outgrowth after stroke in the mouse (2010), PLoS ONE, 5, e9027.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information in vivo, administration of mesenchymal stromal cells to mice subjected to middle cerebral artery occlusion significantly increases activation of tPA and downregulates PAI-1 levels in the ischemic boundary zone compared with control PBS treated mice, concurrently with increases of myelinated axons and synaptophysin Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
plasminogen activator inhibitor 1 PAI-1, specific endogenous inhibitor, in vivo, administration of mesenchymal stromal cells to mice subjected to middle cerebral artery occlusion significantly increases activation of tPA and downregulates PAI-1 levels in the ischemic boundary zone compared with control PBS treated mice, concurrently with increases of myelinated axons and synaptophysin Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Mus musculus
-
neuron
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
Tissue plasminogen activator
-
 Mus musculus
tPA
-
 Mus musculus

General Information

General Information Comment Organism
physiological function tissue plasminogen activator, tPA, and its inhibitors contribute to neurite outgrowth in the central nervous system after treatment of stroke with multipotent mesenchymal stromal cells. Critical role of tPA in facilitating neurite outgrowth. Bone marrow stromal cells modulate endogenous tPA level and activity in the ischemic boundary zone, IBZ Mus musculus