Activating Compound | Comment | Organism | Structure |
---|---|---|---|
fibrinogen | activation induced by | Homo sapiens | |
fibrinogen | activation induced by | Bos taurus |
Cloned (Comment) | Organism |
---|---|
heterologously expressed in the methylotrophic yeast Pichia pastoris GS115 | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
epsilon-aminocaproic acid | - |
Bos taurus | |
plasminogen activator inhibitor PAI-1 | - |
Bos taurus | |
plasminogen activator inhibitor PAI-2 | - |
Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0001 | - |
plasminogen | pH 7.4, 37°C | Homo sapiens | |
0.0001 | - |
plasminogen | pH 7.4, 37°C | Bos taurus | |
0.005 | - |
plasminogen | pH 7.4, 37°C, absence of fibrinogen | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
naked tPA amino acid chain | Bos taurus |
68000 | - |
natively glycosylated tPA | Homo sapiens |
80000 | - |
mass spectroscopy, SDS-PAGE | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Homo sapiens | single-chain tPA mediated activation | plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
bovine | - |
Homo sapiens | - |
human | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | single-chain tPA mediated activation | Homo sapiens | plasmin + ? | - |
? | |
plasminogen + H2O | - |
Bos taurus | ? | - |
? | |
Val-Leu-Lys-p-nitroanilide + H2O | i.e. S-2251 | Bos taurus | p-nitroaniline + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tissue-type plasminogen activator | - |
Homo sapiens |
Tissue-type plasminogen activator | - |
Bos taurus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0025 | - |
plasminogen | pH 7.4, 37°C, absence of fibrinogen | Bos taurus |