Application | Comment | Organism |
---|---|---|
medicine | although rtPA enhances ischemic damage, the dose of recombinant tPA used in clinics does not affect the powerful neuroprotection by the JNK inhibitor XG-102 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | addition of human recombinant tPA after ischemia, in a mouse model of transient 30-min-suture middle cerebral artery occlusion, enhances ischemic damage both in vitro and in vivo, but XG-102 is able to induce a significant neuroprotection. Addition of recombinant tPA after oxygen and glucose deprivation enhances neuronal death in CA1 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tissue plasminogen activator | - |
Homo sapiens |
tPA | - |
Homo sapiens |