Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.68 extracted from

  • Shen, L.H.; Xin, H.; Li, Y.; Zhang, R.L.; Cui, Y.; Zhang, L.; Lu, M.; Zhang, Z.G.; Chopp, M.
    Endogenous tissue plasminogen activator mediates bone marrow stromal cell-induced neurite remodeling after stroke in mice (2011), Stroke, 42, 459-464.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.68

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Mus musculus
-
 plasmin + ?
-
 ?
plasminogen + H2O Mus musculus C57BL/6
-
 plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57BL/6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Mus musculus
-
brain
-
 Mus musculus
-
additional information tPA colocalizes with neuronal marker MAP2, astrocytic marker glial fibrillary acidic protein, microglial marker isolectin IB4, or endothelial marker von Willebrand factor, overview Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O
-
 Mus musculus ?
-
 ?
casein + H2O
-
 Mus musculus C57BL/6 ?
-
 ?
plasminogen + H2O
-
 Mus musculus plasmin + ?
-
 ?
plasminogen + H2O
-
 Mus musculus C57BL/6 plasmin + ?
-
 ?

Synonyms

Synonyms Comment Organism
Tissue plasminogen activator
-
 Mus musculus
tPA
-
 Mus musculus

General Information

General Information Comment Organism
physiological function tissue plasminogen activator, tPA, is the primary source of plasminogen activator in the brain, and is a member of the fibrinolytic system and a serine protease that converts the zymogen plasminogen into the active protease plasmin, and thus cleaves fibrin and dissolves newly formed clots. Bone marrow stromal cells significantly improve functional recovery from stroke dependent on tPA function, overview. In tPA knockout mice, no bone marrow stromal cell effect is observed on functional recovery Mus musculus