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Literature summary for 3.4.21.68 extracted from
- Expression and large-scale production of the biochemically active human tissue-plasminogen activator in hairy roots of Oriental melon (Cucumis melo) (2012), J. Biosci. Bioeng., 113, 106-111.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinant expression and large-scale production of biochemically active wild-type human enzyme and os a synthetic enzyme in hairy roots of Cucumis melo cv. Geumssaragi-euncheon using binary vector p221 and Agrobacterium rhizogenes strain K599-mediated transformation of cotyledons, method evaluation, overview. WPM medium is found to be more suitable for rapid growth of hairy roots among all the seven media types tested, total yield of hairy roots grown on WPM medium is 621.8 g/L at pH 7.0 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| PAI-1 inhibitor | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 59000 | - |
x * 59000, recombinant enzyme, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | Homo sapiens | activation | plasmin + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | activation | Homo sapiens | plasmin + ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 59000, recombinant enzyme, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| t-PA | - |
Homo sapiens |
| tissue-plasminogen activator | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | human tissue-plasminogen activator is a thrombolytic protein that plays an active role in dissolving fibrin clots by fibrinolysis and in activating plasminogen to plasmin in blood vessels | Homo sapiens |
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