Application | Comment | Organism |
---|---|---|
medicine | the present data support a model in which amyloid deposition in Alzheimer's disease induces a decrease in tPA activity through the overproduction of PAI-1 by activated glial cells | Mus musculus |
medicine | the present data support a model in which amyloid deposition in Alzheimer's disease induces a decrease in tPA activity through the overproduction of PAI-1 by activated glial cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
plasminogen activator inhibitor type 1 (PAI-1) | - |
Homo sapiens | |
plasminogen activator inhibitor type 1 (PAI-1) | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | a decreased expression on the protein and on the mRNA level in elderly mice and in mice overproducing amyloid-beta peptide assemblies is shown | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
a study in sporadic Alzheimer's disease and age-matched control brain tissues reveals that the tPA proteolytic activity is negatively correlated to amyloid-beta peptide levels | Homo sapiens |
additional information | - |
cerebral tPA activity is decreased during ageing in normal mice and this effect is worsened in mice overproducing amyloid-beta peptide assemblies. These phenomena result from a decrease in tPA expression and from an increase in the production of one of the tPA inhibitors, the plasminogen activator inhibitor type 1 (PAI-1) | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
methylsulfonyl-D-Phe-Gly-Arg-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | methylsulfonyl-D-Phe-Gly-Arg + 7-amino-4-methylcoumarin | - |
? | |
methylsulfonyl-D-Phe-Gly-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | methylsulfonyl-D-Phe-Gly-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tPA | - |
Mus musculus |
tPA | - |
Homo sapiens |