Application | Comment | Organism |
---|---|---|
medicine | combining antithrombin III, R-TPA and supportive care is more advantageous in treating the clinical manifestations of disseminated intravascular coagulation in this neonatal pig model than either single modality or supportive care alone | Sus scrofa |
Protein Variants | Comment | Organism |
---|---|---|
additional information | disseminated intravascular coagulation is induced in 27 neonatal pigs (7 to 14 days of age) by intravenous administration of Escherichia coli endotoxin (800 microgram/kg over 30 min). Pigletes are treated with A: supportive care alone, B: antithrombin III (50 microgram/kg bolus, 25 microgram/kg per h continuous infusion) and supportive care, C: recombinant tissue plasminogen activator (R-TPA, 25 mcrogram/kg per h continuous infusion) and supportive care; D: antithrombin III, R-TPA and supportive care. Compared with supportive care alone, combination therapy with antithrombin III and R-TPA results in a significant improvement of survival time, hematocrit, antithrombin III level, macroscopic and microscopic organ involvement. Compared with supportive care alone, R-TPA alone significantly reduces macroscopic organ involvement | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
r-tPA | - |
Sus scrofa |
recombinant tissue plasminogen activator | - |
Sus scrofa |