Any feedback?
Literature summary for 3.4.21.68 extracted from
- The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage (1988), Biochim. Biophys. Acta, 952, 245-254.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Fibrin | fibrin-binding induces an activated state of the intact one-chain form | Homo sapiens |  |
| Polymerized fibrin | enhances amidolytic activity of both one-chain tPA forms but not of two-chain tPA | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
construction of a one-chain recombinant tissue-type plasminogen activator analogue in which Arg275 is changed to Gly by site-directed mutagenesis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
