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Literature summary for 3.4.21.68 extracted from

  • Garcia-Vazquez, F.A.; Soriano-Ubeda, C.; Laguna-Barraza, R.; Izquierdo-Rico, M.J.; Navarrete, F.A.; Visconti, P.E.; Gutierrez-Adan, A.; Coy, P.
    Tissue plasminogen activator (tPA) of paternal origin is necessary for the success of in vitro but not of in vivo fertilisation in the mouse (2019), Reprod. Fertil. Dev., 31, 433-442 .
    View publication on PubMed
Search for more literature for 3.4.21.68

Inhibitors

Inhibitors Comment Organism Structure
alpha-antiplasmin alpha-PL Mus musculus
epsilon-aminocaproic acid EACA Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Mus musculus
-
 plasmin + ?
-
 ?
plasminogen + H2O Mus musculus CD-1
-
 plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P11214
-
-
Mus musculus CD-1 P11214
-
-

Source Tissue

Source Tissue Comment Organism Textmining
oocyte
-
 Mus musculus
-
ovarian cumulus cell
-
 Mus musculus
-
spermatozoon
-
 Mus musculus
-
zona pellucida
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
 Mus musculus plasmin + ?
-
 ?
plasminogen + H2O
-
 Mus musculus CD-1 plasmin + ?
-
 ?

Synonyms

Synonyms Comment Organism
PLAT
-
 Mus musculus
Tissue plasminogen activator
-
 Mus musculus
tPA
-
 Mus musculus

General Information

General Information Comment Organism
metabolism the plasminogen-plasmin (PLG-PLA) system plays a role in thrombolysis, being capable of degrading blood clots. THe system consists of plasminogen, the inactive zymogen produced principally in the liver, its activators (tissue plasminogen activator, tPA and uroquinase plasminogen activator, uPA (EC 3.4.21.73)), their inhibitors (belonging to the serpin gene superfamily, named PAI-1, PAI-2, PAI-3 and protease nexin I), the uPA receptor and, finally, the active enzyme plasmin and its inhibitor, alpha-antiplasmin (alpha-PL). Apart from its fibrinolytic function, the PLG-PLA system is important in degrading the extracellular matrix in multiple tissues contributing to cell migration, angiogenesis, tissue repair and remodelling or tumour invasion Mus musculus
additional information tPA is active in solution Mus musculus
physiological function tissue plasminogen activator (tPA) of paternal origin is necessary for the success of in vitro but not of in vivo fertilisation in the mouse. The presence of exogenous plasminogen drastically reduces the fertilisation rate under in vitro conditions. When plasminogen is present in combination with inhibitors (e.g. alpha-PL or EACA), the fertilisation rate is partially restored Mus musculus