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Literature summary for 3.4.21.68 extracted from
- Effect of dsRNA on mesangial cell synthesis of plasminogen activator inhibitor type 1 and tissue plasminogen activator (2009), Nephron Exp. Nephrol., 113, 57-65.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| plasminogen activator inhibitor type 1 | an important inhibitor of plasminogen activators | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | Homo sapiens | - |
plasmin + ? | plasmin is a potent broad-spectrum protease that cleaves fibrin and is able to degrade several components of the extracellular matrix by activating procollagenases and matrix metalloproteinases | ? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P00750 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mesangial cell | incubated with culture medium containing polyriboinosinic:polyribocytidylic acid RNA in different concentrations | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | - |
Homo sapiens | plasmin + ? | plasmin is a potent broad-spectrum protease that cleaves fibrin and is able to degrade several components of the extracellular matrix by activating procollagenases and matrix metalloproteinases | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Tissue plasminogen activator | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | basal expression of tissue plasminogen activator is not affected by any of the proinflammatory cytokines TNF-alpha, IL-1beta and IFN-gamma individually or in combination, no increase in tissue plasminogen activator synthesis is observed by ELISA when cells are stimulated with viral polyriboinosinic:polyribocytidylic acid RNA for 3 and 6 h, both with and without cytokine pretreatment | additional information |
| Homo sapiens | viral polyriboinosinic:polyribocytidylic acid RNA in the culture medium increases mesangial tissue plasminogen activator expression, exposure of mesangial cells to viral polyriboinosinic:polyribocytidylic acid RNA at a concentration of 0.5 or 5 microg/ml increases significantly tissue plasminogen activator mRNA levels in a dose-dependent manner, an effect which is further enhanced with pretreatment of mesangial cells with the cytokine combination, a significant increase in tissue plasminogen activator protein is observed only when cells are pretreated with the combination of proinflammatory cytokines and additionally stimulated with viral polyriboinosinic:polyribocytidylic acid RNA, after 12 and 24 h of polyriboinosinic:polyribocytidylic acid RNA stimulation, tissue plasminogen activator release increases significantly under basal conditions, an effect which is further enhanced when cells are pretreated with the cytokine combination, the maximum increase is observed at 24 h | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | tissue plasminogen activator and plasminogen activator inhibitor type 1 are the major regulators of plasmin generation, tissue plasminogen activator plays a pivotal role in the fibrinolytic system by converting the proenzyme plasminogen into the active enzyme plasmin | Homo sapiens |
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