Literature summary for 3.4.21.68 extracted from

Hu, X.Y.; Ma, Y.H.; Wang, C.; Yang, Y.H.
Effects of simvastatin on cigarette smoke extract induced tissue-type plasminogen activator and plasminogen activator inhibitor-1 expression in human umbilical vein endothelial cells (2009), Chin. Med. Sci., 122, 2380-2385.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
umbilical vein endothelial cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
t-PA protein	-	Homo sapiens
Tissue-type plasminogen activator	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	after 6-h exposure to cigarette smoke extract, the expression levels of t-PA protein in 10% and 20% cigarette smoke extract-treated groups reduce significantly when compared with that of control group	down
Homo sapiens	after stimulation with 5% cigarette smoke extract for 0, 4, 6, 8, 12, 24 hours, no significant difference is found at the levels of tissue plasminogen protein and mRNA after 2-h simvastatin pre-treatment	additional information

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Release 2023.1 (January 2023)