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3.1.4.37: 2',3'-cyclic-nucleotide 3'-phosphodiesterase

This is an abbreviated version!
For detailed information about 2',3'-cyclic-nucleotide 3'-phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.37

Reaction

nucleoside 2',3'-cyclic phosphate
+
H2O
=
Nucleoside 2'-phosphate

Synonyms

2',3'-cyclic AMP phosphodiesterase, 2',3'-cyclic nucleoside monophosphate phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphohydrolase, 2',3'-cyclic nucleotide phosphodiesterase, 2',3'-cyclic nucleotide phosphohydrolase, 2',3'-cyclic nucleotide-3'-phosphodiesterase, 2',3'-cyclic nucleotide-3'-phosphohydrolase, 2',3'-cyclic phosphodiesterase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, 2':3'-CNMP-3'-ase, 2':3'-cyclic nucleotide 3'-phosphodiesterase, 3DMA, CNP, CNP1, CNP2, CNPase, CNPase I, cyclic 2',3'-nucleotide 3'-phosphodiesterase, cyclic 2',3'-nucleotide phosphodiesterase, cyclic-CMP phosphodiesterase, DGC2, nucleoside-2':3'-cyclic-phosphate 2'-nucleotidohydrolase, PaAcpH, phosphodiesterase, cyclic 2',3'-nucleotide 3'-, PNKP, RocR, YtqI, YybT

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase

Substrates Products

Substrates Products on EC 3.1.4.37 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1,N6-etheno-2-azaadenosine-2',3'-cyclic monophosphate + H2O
etheno-2-azaadenosine-2'-monophosphate
show the reaction diagram
-
-
-
-
?
1,N6-ethenoadenosine-2',3'-cyclic monophosphate + H2O
ethenoadenosine-2'-monophosphate
show the reaction diagram
-
-
-
-
?
2', 3'-cyclic ribonucleotide
ribonucleoside 2'-phosphate
show the reaction diagram
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
show the reaction diagram
2',3'-cAMP + H2O
2'-AMP + 3'-AMP
show the reaction diagram
-
-
-
?
2',3'-cAMP + H2O
3'-AMP + ?
show the reaction diagram
-
the exclusive formation of 3'-AMP is due to the P-O2' bond having lower activation energy and is not the result of steric exclusion at enzyme active site, kinetic evidence that hydrolysis of 2',3'-cAMP into 3'-AMP is nonspecific. Modeling of 2',3'-cyclic nucleotide into the active site of a EAL domain PDE, overview
-
-
?
2',3'-cCMP + H2O
2'-CMP
show the reaction diagram
2',3'-cGMP + H2O
2'-GMP
show the reaction diagram
2',3'-cGMP + H2O
2'-GMP + 3'-GMP
show the reaction diagram
-
-
-
?
2',3'-cNADP+ + H2O
2'-NADP+
show the reaction diagram
2',3'-cNADP+ + H2O
?
show the reaction diagram
-
-
-
?
2',3'-cNADP+ + H2O
NADP+
show the reaction diagram
2',3'-cUMP + H2O
2'-UMP
show the reaction diagram
2',3'-cyclic AMP + H2O
2'-AMP
show the reaction diagram
2',3'-cyclic NADP+ + H2O
NADP+
show the reaction diagram
2',3'-cyclic-2-aza-e-AMP + H2O
2'-2-aza-e-AMP
show the reaction diagram
-
-
-
-
?
2',3'-cyclic-e-AMP + H2O
2'-e-AMP
show the reaction diagram
-
-
-
-
?
2'-AMP + H2O
adenosine + phosphate
show the reaction diagram
-
-
-
?
3'-AMP + H2O
?
show the reaction diagram
-
-
-
-
?
adenosine 2,3-cyclic phosphorothioate + H2O
?
show the reaction diagram
the Sp epimer of 2',3'-cAMPS is a functional substrate for the enzyme, while the Rp epimer is not
-
-
?
ADP + H2O
AMP + phosphate
show the reaction diagram
-
-
-
?
ATP + H2O
ADP + phosphate
show the reaction diagram
-
-
-
?
bis(p-nitrophenyl)phosphate + H2O
?
show the reaction diagram
-
non-specific substrate
-
-
?
bis-p nitrophenyl phosphate + H2O
?
show the reaction diagram
-
-
-
-
?
bis-p-nitrophenyl phosphate + H2O
?
show the reaction diagram
-
-
?
CDP + H2O
CMP + phosphate
show the reaction diagram
-
-
-
?
CTP + H2O
CDP + phosphate
show the reaction diagram
-
-
-
?
cyclic 2',3'-AMP + H2O
2'-AMP
show the reaction diagram
cyclic 2',3'-CMP + H2O
2'-CMP
show the reaction diagram
low activity
-
?
cyclic 2',3'-GMP + H2O
2'-GMP
show the reaction diagram
high activity
-
?
diphosphate + H2O
2 phosphate
show the reaction diagram
-
-
-
?
NADP+ + H2O
NAD+ + phosphate
show the reaction diagram
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
show the reaction diagram
nucleoside 2',3'-cyclic phosphates + H2O
?
show the reaction diagram
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
show the reaction diagram
-
-
-
?
additional information
?
-