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1,N6-etheno-2-azaadenosine-2',3'-cyclic monophosphate + H2O
etheno-2-azaadenosine-2'-monophosphate
-
-
-
-
?
1,N6-ethenoadenosine-2',3'-cyclic monophosphate + H2O
ethenoadenosine-2'-monophosphate
-
-
-
-
?
2', 3'-cyclic ribonucleotide
ribonucleoside 2'-phosphate
-
-
-
?
2',3'-cAMP + H2O
2'-AMP + 3'-AMP
-
-
-
?
2',3'-cAMP + H2O
3'-AMP + ?
-
the exclusive formation of 3'-AMP is due to the P-O2' bond having lower activation energy and is not the result of steric exclusion at enzyme active site, kinetic evidence that hydrolysis of 2',3'-cAMP into 3'-AMP is nonspecific. Modeling of 2',3'-cyclic nucleotide into the active site of a EAL domain PDE, overview
-
-
?
2',3'-cGMP + H2O
2'-GMP + 3'-GMP
-
-
-
?
2',3'-cNADP+ + H2O
2'-NADP+
2',3'-cNADP+ + H2O
?
-
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
2',3'-cyclic NADP+ + H2O
NADP+
2',3'-cyclic-2-aza-e-AMP + H2O
2'-2-aza-e-AMP
-
-
-
-
?
2',3'-cyclic-e-AMP + H2O
2'-e-AMP
-
-
-
-
?
2'-AMP + H2O
adenosine + phosphate
-
-
-
?
adenosine 2,3-cyclic phosphorothioate + H2O
?
the Sp epimer of 2',3'-cAMPS is a functional substrate for the enzyme, while the Rp epimer is not
-
-
?
ADP + H2O
AMP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
bis(p-nitrophenyl)phosphate + H2O
?
-
non-specific substrate
-
-
?
bis-p nitrophenyl phosphate + H2O
?
-
-
-
-
?
bis-p-nitrophenyl phosphate + H2O
?
-
-
?
CDP + H2O
CMP + phosphate
-
-
-
?
CTP + H2O
CDP + phosphate
-
-
-
?
cyclic 2',3'-AMP + H2O
2'-AMP
cyclic 2',3'-CMP + H2O
2'-CMP
low activity
-
?
cyclic 2',3'-GMP + H2O
2'-GMP
high activity
-
?
diphosphate + H2O
2 phosphate
-
-
-
?
NADP+ + H2O
NAD+ + phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
nucleoside 2',3'-cyclic phosphates + H2O
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
-
-
-
?
additional information
?
-
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
the protein consists of two domains: an uncharacterized N-terminal domain with little homology to other proteins, and a C-terminal phosphodiesterase domain. C-terminal tail (22 residues) has no significant effect on the catalytic activity, neither do the first 24 N-terminal residues of the full-length protein. Both the N- and C-terminal domain of recombinant CNPase are folded entities: N-terminal domain has more beta-sheet structure and less alpha-helices than the C-terminal domain
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cAMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
-
?
2',3'-cCMP + H2O
2'-CMP
-
-
-
-
?
2',3'-cGMP + H2O
2'-GMP
-
-
-
-
?
2',3'-cGMP + H2O
2'-GMP
-
-
-
-
?
2',3'-cGMP + H2O
2'-GMP
-
-
-
-
?
2',3'-cGMP + H2O
2'-GMP
-
-
-
-
?
2',3'-cGMP + H2O
2'-GMP
-
-
-
-
?
2',3'-cGMP + H2O
2'-GMP
-
-
-
-
?
2',3'-cNADP+ + H2O
2'-NADP+
-
-
-
-
?
2',3'-cNADP+ + H2O
2'-NADP+
-
-
-
?
2',3'-cNADP+ + H2O
2'-NADP+
-
-
-
-
?
2',3'-cNADP+ + H2O
2'-NADP+
-
-
-
-
?
2',3'-cNADP+ + H2O
NADP+
-
-
-
?
2',3'-cNADP+ + H2O
NADP+
-
-
-
?
2',3'-cNADP+ + H2O
NADP+
-
-
-
-
?
2',3'-cUMP + H2O
2'-UMP
-
-
-
-
?
2',3'-cUMP + H2O
2'-UMP
-
-
-
-
?
2',3'-cUMP + H2O
2'-UMP
-
-
-
-
?
2',3'-cUMP + H2O
2'-UMP
-
-
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
product binding structure, overview
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
substrate and product enzyme binding structures, overview
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cyclic AMP + H2O
2'-AMP
-
-
-
-
?
2',3'-cyclic NADP+ + H2O
NADP+
-
-
-
-
?
2',3'-cyclic NADP+ + H2O
NADP+
-
-
-
-
?
2',3'-cyclic NADP+ + H2O
NADP+
-
-
-
?
2',3'-cyclic NADP+ + H2O
NADP+
-
-
-
-
?
cyclic 2',3'-AMP + H2O
2'-AMP
-
-
-
-
?
cyclic 2',3'-AMP + H2O
2'-AMP
best substrate
-
?
cyclic 2',3'-AMP + H2O
2'-AMP
natural substrate, the 2',3'-cyclic phosphodiesterase activity of the C-terminal HD domain of tRNA nucleotidyltransferase, EC 2.7.7.25, is involved in the repair of the 3-CCA end of tRNA
-
?
cyclic 2',3'-AMP + H2O
2'-AMP
-
-
-
?
cyclic 2',3'-AMP + H2O
2'-AMP
-
-
-
-
?
cyclic 2',3'-AMP + H2O
2'-AMP
-
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
dinucleotide binding mode, overview
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
activity resides in the C-terminus
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
His-230 and His-309 of CNP1 play critical roles in enzyme catalysis, no essential role of cysteines, the catalytic domain forms a compact globular structure
-
ir
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
plays a role in cytoskeletal rearrangement, cell morphology and cell process outgrowth, increased expression of CNP is a marker for oligodendrocyte development
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphate + H2O
nucleoside 2'-phosphate
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
nucleoside 2',3'-cyclic phosphates + H2O
?
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
-
?
additional information
?
-
-
not: nucleoside 3',5'-cyclic phosphate
-
?
additional information
?
-
not: nucleoside 3',5'-cyclic phosphate
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
-
?
additional information
?
-
-
endogenous Nogo-A interacts with the endogenous CNP in vitro and in vivo
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
-
?
additional information
?
-
-
early stages of myelin formation
-
-
?
additional information
?
-
-
the cAMP-mediated pathway is part of the molecular mechanisms regulating the expression of CNP1 in oligodendrocytes, roles of AP-2, AP-4 and nuclear factor-1 in the regulation of CNP1 expression
-
?
additional information
?
-
-
enzyme is involved in mediating process formation in oligodendrocytes
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
three enzyme forms
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
-
?
additional information
?
-
-
CNP acts as microtubule-associated protein in promoting microtubule assembly at low mole ratios, links tubulin to membranes and may regulate cytoplasmic microtubule distribution, membrane anchor for tubulin
-
?
additional information
?
-
-
CNP is one of the earliest myelin-related proteins to be expressed in differentiated oligodendrocytes and Schwann cells, role in migration and/or expansion of membranes during myelination
-
?
additional information
?
-
-
CNP performs an integral role in myelinogenesis, both isoforms likely play complementary roles in the onset of process outgrowth and ultimately myelination of axons
-
?
additional information
?
-
-
early oligodendroglial marker, CNPase links myelin related proteins to the cytoskeleton also interacting with membrane lipids during extension and wrapping of the oligodendroglial process around the axon, in mature myelinated fiber the CNPase is absent from compact myelin sheath, being located only in the inner and outer loops and in paranodal loops
-
?
additional information
?
-
-
myelin-specific protein, synthesized by oligodendrocytes, more abundant in the myelin of the CNS than in that of the peripheral nervous system, CNP is regulated by several protein kinases and may have a role in morphological changes of the cells by modulating the cytoskeleton
-
?
additional information
?
-
-
non-compact myelin protein, may have a unique role in signaling pathways mediated by lipid-protein domains
-
?
additional information
?
-
-
related to axonal ensheathment by myelinating cells
-
?
additional information
?
-
-
the cAMP-mediated pathway is part of the molecular mechanisms regulating the expression of CNP1 in oligodendrocytes, roles of AP-2, AP-4, nuclear factor-1 and protein kinase A in the regulation of CNP1 expression
-
?
additional information
?
-
-
endogenous enzyme expression is augmented by juxtanodin transfection, an oligodendroglial protein that promotes cellular arborization. Juxtanodin also augments transport of enzyme to the process arbors of cultured primary oligodendrocyte precursors
-
-
?
additional information
?
-
-
enzyme can perform the essential 3'-end-healing steps of tRNA splicing in yeast and complement growth of strains bearing lethal or temperature-sensitive mutations in the tRNA ligase 3'-end-healing domain
-
-
?
additional information
?
-
-
enzyme binds purine nucleotide triphosphates with an affinity higher than that displayed for diphosphates, while the affinity for both purine monophosphates and pyrimidine nucleotides is negligible. Analysis of binding constants for GTP, GDP, GMP, ATP, ADP, CTP, CDP, UTP, UDP
-
-
?
additional information
?
-
-
CNP is an RNA-binding protein, CNP associates with poly(A)+ mRNAs in vivo and suppresses translation in vitro in a dose-dependent manner, isoform CNP1 may regulate expression of mRNAs in oligodendrocytes of the central nervous system
-
-
?
additional information
?
-
-
substrate specificities and activities of RocR, DGC2, YybT, YtqI, 3DMA, and PaAcpH with 2',3'-cAMP, overview
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
-
?
additional information
?
-
-
not: 2',3'-cyclic esters in cyclic phosphate-terminated oligoribonucleotides or in nucleoside 5'-phosphate, 2',3'-cyclic phosphate
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
not: 3',5'-cyclic nucleotides
-
-
?