3.1.4.37: 2',3'-cyclic-nucleotide 3'-phosphodiesterase

This is an abbreviated version!
For detailed information about 2',3'-cyclic-nucleotide 3'-phosphodiesterase, go to the full flat file.

Reaction

Synonyms

2',3'-cyclic AMP phosphodiesterase, 2',3'-cyclic nucleoside monophosphate phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphodiesterase, 2',3'-cyclic nucleotide 3'-phosphohydrolase, 2',3'-cyclic nucleotide phosphodiesterase, 2',3'-cyclic nucleotide phosphohydrolase, 2',3'-cyclic nucleotide-3'-phosphodiesterase, 2',3'-cyclic nucleotide-3'-phosphohydrolase, 2',3'-cyclic phosphodiesterase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, 2':3'-CNMP-3'-ase, 2':3'-cyclic nucleotide 3'-phosphodiesterase, 3DMA, CNP, CNP1, CNP2, CNPase, CNPase I, cyclic 2',3'-nucleotide 3'-phosphodiesterase, cyclic 2',3'-nucleotide phosphodiesterase, cyclic-CMP phosphodiesterase, DGC2, nucleoside-2':3'-cyclic-phosphate 2'-nucleotidohydrolase, PaAcpH, phosphodiesterase, cyclic 2',3'-nucleotide 3'-, PNKP, RocR, YtqI, YybT

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.4 Phosphoric-diester hydrolases

                3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase

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Results	in table
35	Activating Compound
1145	AA Sequence
7	Application
1	CAS Registry Number
27	Cloned(Commentary)
8	Crystallization (Commentary)
284	Disease/ Diagnostics
11	Expression
39	General Information
8	General Stability
117	Inhibitors
19	kcat/KM [mM/s]
6	Ki Value [mM]
112	KM Value [mM]
72	Localization
37	Metals/Ions
72	Molecular Weight [Da]
70	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
631	Organism
38	PDB ID
15	pH Optimum
3	pH Range
1	pH Stability
3	pI Value
14	Posttranslational Modification
73	Protein Variants
22	Purification (Commentary)
4	Reaction
2	Reaction Type
136	Reference
287	Source Tissue
58	Specific Activity [micromol/min/mg]
10	Storage Stability
268	Substrates and Products (Substrate)
49	Subunits
102	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
2	Temperature Range [°C]
10	Temperature Stability [°C]
72	Turnover Number [1/s]

KM Value

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KM Value on EC 3.1.4.37 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

10

1,N6-Etheno-2-azaadenosine-2',3'-cyclic monophosphate

Rattus norvegicus

-

-

135380

8.3

1,N6-Ethenoadenosine-2',3'-cyclic monophosphate

Rattus norvegicus

-

rat brain

135380

0.25 - 13.1

2',3'-cAMP

13 entries

0.8 - 25.2

2',3'-cCMP

3 entries

0.57 - 9.2

2',3'-cGMP

3 entries

0.098 - 0.55

2',3'-cNADP

16 entries

0.483 - 39.648

2',3'-cNADP+

13 entries

8.3 - 25.3

2',3'-cUMP

2 entries

0.553 - 1.305

2',3'-Cyclic AMP

5 entries

0.76

2'-AMP

Escherichia coli

P06961

+/- 0.13

652555

0.046

3'-AMP

Bacillus subtilis

-

-

135405

0.19

ADP

Escherichia coli

P06961

+/- 0.02

652555

0.18

ATP

Escherichia coli

P06961

+/- 0.01

652555

0.16

bis-p-nitrophenyl phosphate

Bacillus subtilis

-

-

135405

0.53

CDP

Escherichia coli

P06961

+/- 0.09

652555

0.13

CTP

Escherichia coli

P06961

+/- 0.01

652555

0.49 - 100

cyclic 2',3'-AMP

19 entries

1.6

cyclic 2',3'-GMP

Escherichia coli

P06961

pH 7, 37°C

652555

0.1

diphosphate

Escherichia coli

P06961

+/- 0.004

652555

0.15

NADP

Escherichia coli

P06961

+/- 0.02

652555

6.2

p-nitrophenyl phosphate

Escherichia coli

P06961

+/- 0.46

652555

additional information

additional information

24 entries

-

0.25

2',3'-cAMP

Homo sapiens

-

-

135394

0.32

2',3'-cAMP

Danio rerio

-

H7-zRICH-WT mutant

135417

0.37

2',3'-cAMP

Bos taurus

-

-

135388

0.38

2',3'-cAMP

Sus scrofa

-

pig cerebral white matter

135380

0.39

2',3'-cAMP

Danio rerio

-

H7-zRICH-C339A mutant

135417

0.49

2',3'-cAMP

Escherichia coli

P06961

+/- 0.04

652555

0.537

2',3'-cAMP

Mus musculus

-

full-length protein

707896

1.64

2',3'-cAMP

Rattus norvegicus

-

pH 6.2, 37°C

668237

1.9

2',3'-cAMP

Bos taurus

-

bovine brain

135380

2.15

2',3'-cAMP

Rattus norvegicus

-

pH 6.2, 37°, treatment with lead

668237

2.5

2',3'-cAMP

Danio rerio

-

H7-zRICH-R332A mutant

135417

6

2',3'-cAMP

Rattus norvegicus

-

rat brain

135380, 135404

13.1

2',3'-cAMP

Triticum aestivum

-

-

135387

0.8

2',3'-cCMP

Bos taurus

-

bovine brain

135380

5.6

2',3'-cCMP

Bos taurus

-

bovine brain, elastase fragment

135380

25.2

2',3'-cCMP

Triticum aestivum

-

-

135387

0.57

2',3'-cGMP

Bos taurus

-

bovine brain

135380

1.6

2',3'-cGMP

Escherichia coli

P06961

+/- 0.22

652555

9.2

2',3'-cGMP

Triticum aestivum

-

-

135387

0.098

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, H309L mutant CNP1

652106

0.1

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, H309F mutant CNP1

652106

0.104

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, H230L mutant CNP1

652106

0.119

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, H230F mutant CNP1

652106

0.23

2',3'-cNADP

Bos taurus

-

bovine spinal cord

135380

0.231

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C231A mutant CNP1

652106

0.237

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, recombinant full-length CNP1

652106

0.241

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C314S mutant CNP1

652106

0.295

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, catalytic fragment of CNP1 corresponding to the C-terminal 250 amino acids

652106

0.333

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C314A mutant CNP1

652106

0.354

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C236A mutant CNP1

652106

0.379

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C236S mutant CNP1

652106

0.47

2',3'-cNADP

Rattus norvegicus

-

rat brain

135380

0.473

2',3'-cNADP

Rattus norvegicus

-

pH 6, 25°C, C231S mutant CNP1

652106

0.51

2',3'-cNADP

Rattus norvegicus

-

rat liver

135380

0.55

2',3'-cNADP

Bos taurus

-

-

135388

0.483

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme P225G, pH and temperature not specified in the publication

752180

0.553

2',3'-cNADP+

Mus musculus

P16330

wild type enzyme, pH and temperature not specified in the publication

752180

0.722

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme P296G, pH and temperature not specified in the publication

752180

1.045

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme V321A, pH and temperature not specified in the publication

752180

1.055

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme H230Q, pH and temperature not specified in the publication

752180

1.192

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme H309S, pH and temperature not specified in the publication

752180

1.305

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme H230S, pH and temperature not specified in the publication

752180

1.385

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme Y168S, pH and temperature not specified in the publication

752180

1.879

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme Y168A, pH and temperature not specified in the publication

752180

2.192

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme R307Q, pH and temperature not specified in the publication

752180

3.788

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme F235L, pH and temperature not specified in the publication

752180

6.253

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme F235A, pH and temperature not specified in the publication

752180

39.648

2',3'-cNADP+

Mus musculus

P16330

mutant enzyme T232A, pH and temperature not specified in the publication

752180

8.3

2',3'-cUMP

Bos taurus

-

bovine brain

135380

25.3

2',3'-cUMP

Triticum aestivum

-

-

135387

0.553

2',3'-Cyclic AMP

Mus musculus

P16330

wild-type enzyme, pH and temperature not specified in the publication

730215

1.045

2',3'-Cyclic AMP

Mus musculus

P16330

mutant V321A, pH and temperature not specified in the publication

730215

1.055

2',3'-Cyclic AMP

Mus musculus

P16330

mutant H230Q, pH and temperature not specified in the publication

730215

1.192

2',3'-Cyclic AMP

Mus musculus

P16330

mutant H309S, pH and temperature not specified in the publication

730215

1.305

2',3'-Cyclic AMP

Mus musculus

P16330

mutant H230S, pH and temperature not specified in the publication

730215

0.49

cyclic 2',3'-AMP

Escherichia coli

P06961

pH 7, 37°C

652555

3.9

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant H376D, pH 7.5, 45°C

682186

4.7

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant H376N, pH 7.5, 45°C

682186

6.6

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant D236N, pH 7.5, 45°C

682186

7.8

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant D236A, pH 7.5, 45°C

682186

18

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant D236E, pH 7.5, 45°C

682186

18

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant D392E, pH 7.5, 45°C

682186

18

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

wild-type, pH 7.5, 45°C

682186

20

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant H189D, pH 7.5, 45°C

682186

24

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant H323Q, pH 7.5, 45°C

682186

28

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant H189E, pH 7.5, 45°C

682186

29

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant H189A, pH 7.5, 45°C

682186

31

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant D392N, pH 7.5, 45°C

682186

32

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant H323A, pH 7.5, 45°C

682186

60

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant R237Q, pH 7.5, 45°C

682186

62

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant D233E, pH 7.5, 45°C

682186

77

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant R237A, pH 7.5, 45°C

682186

100

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant D392A, pH 7.5, 45°C

682186

100

cyclic 2',3'-AMP

Acetivibrio thermocellus

-

mutant R237K, pH 7.5, 45°C

682186

additional information

additional information

Gallus gallus

-

-

135380

-

additional information

additional information

Cavia porcellus

-

-

135380

-

additional information

additional information

Haemophilus influenzae

-

-

135380

-

additional information

additional information

Mus musculus

-

-

135380

-

additional information

additional information

Homo sapiens

-

-

135380

-

additional information

additional information

Rattus norvegicus

-

-

135380

-

additional information

additional information

Sus scrofa

-

-

135242

-

additional information

additional information

Sus scrofa

-

-

135380

-

additional information

additional information

Bos taurus

-

-

135380

-

additional information

additional information

Bos taurus

-

-

135382

-

additional information

additional information

Bos taurus

-

-

135383

-

additional information

additional information

Bos taurus

-

-

135388

-

additional information

additional information

Triticum aestivum

-

-

135387

-

additional information

additional information

Oryctolagus cuniculus

-

-

135380

-

additional information

additional information

Ovis aries

-

-

135380

-

additional information

additional information

Arabidopsis thaliana

-

-

135416

-

additional information

additional information

Canis lupus familiaris

-

-

135380

-

additional information

additional information

Canis lupus familiaris

-

-

135382

-

additional information

additional information

Xenopus laevis

-

-

135380

-

additional information

additional information

Chondrichthyes

-

-

135380

-

additional information

additional information

Ophiophagus hannah

-

-

135410

-

additional information

additional information

Artemia sp.

-

-

135415

-

additional information

additional information

Rattus norvegicus

-

three enzyme forms

135413

-

additional information

additional information

Bos taurus

-

in the prescence of serum albumin or hexadecyltrimethylammonium bromide

135389

-