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Literature summary for 3.1.4.37 extracted from

  • Bifulco, M.; Laezza, C.; Stingo, S.; Wolff, J.
    2',3'-Cyclic nucleotide 3'-phosphodiesterase: A membrane-bound, microtubule-associated protein and membrane anchor for tubulin (2002), Proc. Natl. Acad. Sci. USA, 99, 1807-1812.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.37

Cloned(Commentary)

Cloned (Comment) Organism
full-length CNP1 and C-terminal deletion mutant, fused to glutathione S-transferase, expression in Escherichia coli JM83, fused to green fluorescent protein, expression in COS-7 cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information C-terminal deletion of 13 amino acids of CNP1 leads to an abnormal microtubule distribution in the cell Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound, microtubule-associated protein, membrane anchor for tubulin Rattus norvegicus 16020
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microtubule tubulin from brain, microtubule-associated protein, membrane anchor for tubulin, membrane-bound Rattus norvegicus 5874
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additional information subcellular distribution of CNP Rattus norvegicus
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus CNP acts as microtubule-associated protein in promoting microtubule assembly at low mole ratios, links tubulin to membranes and may regulate cytoplasmic microtubule distribution, membrane anchor for tubulin ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein CNP is phosphorylated in vivo by protein kinase C, phosphorylation of CNP1 interferes with its microtubule assembly-promoting activity Rattus norvegicus
side-chain modification CNP is isoprenylated and palmitoylated Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
recombinant CNP1 and C-terminal deletion mutant Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain CNP is associated with tubulin from brain Rattus norvegicus
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FRTL-5 cell ATCC CRL 8305, thyroid cells, CNP is firmly associated with FRTL-5 cells Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2',3'-cAMP + H2O
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 Rattus norvegicus 2'-AMP
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 ?
additional information CNP acts as microtubule-associated protein in promoting microtubule assembly at low mole ratios, links tubulin to membranes and may regulate cytoplasmic microtubule distribution, membrane anchor for tubulin Rattus norvegicus ?
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 ?
nucleoside 2',3'-cyclic phosphate + H2O activity resides in the C-terminus Rattus norvegicus nucleoside 2'-phosphate
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 ?